NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, performs tasks in the Kibo laboratory of the International Space Station while participating in the ambulatory monitoring portion of the Integrated Cardiovascular research experiment. The Integrated Cardiovascular experiment investigates ventricular atrophy associated with long-duration space flight, relates this type of atrophy to measures of physical activity and cardiac work inflight, and determines the time course and pattern of the progression of cardiac atrophy inflight using cardiac ultrasound. This investigation also determines the functional importance of cardiac atrophy for cardiac diastolic function and the regulation of stroke volume (volume of blood pumped by the heart in one contraction) during gravitational transitions, as well as identifies changes in ventricular conduction, depolarization and repolarization during and after long-duration space flight, and relates these factors to changes in heart mass and morphology (shape and form).