ISS Daily Summary Report – 06/05/2015

Defining the Relationship Between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-duration Spaceflight (Cardio Ox): Cristoforetti performed her Return – 15 day (R-15) Cardio Ox ultrasound, with Virts assisting as the on-orbit operator. Following ultrasound scans of brachial and carotid arteries and of the heart, blood pressure readings via the Cardiolab (CDL) Holter Arterial Blood Pressure unit were taken. Cardio Ox will determine whether biological markers of oxidative and inflammatory stress are elevated during and after space flight, and how those markers correlate with the long-term health changes in astronauts. This will help to define the cardiovascular health risks associated with long duration space flight and in developing countermeasures, as well as understanding crew health care needs in the years after their return to Earth.

Human Research Program (HRP) Collections: Kelly and Cristoforetti performed saliva collections in support of Microbiome and Salivary Markers. Kelly also collected samples in support of the 1-Year Mission Experiment Twins Study.

• The Microbiome experiment investigates the impact of space travel on both the human immune system and an individual’s microbiome (the collection of microbes that live in and on the human body at any given time).
• Salivary Markers samples measure markers of latent viral reactivation (a global indicator of immune impairment and infection risk) in conjunction with salivary antimicrobial proteins and immune cell functional assays. This research study will help identify if there are any risks of an adverse health event in crewmembers due to an impaired immune system. If any impairment in immunity is found due to spaceflight, this will allow the development of appropriate countermeasures to help mitigate the risks.
• Twin Study is an integrated compilation of ten different studies led by multiple PI’s at multiple centers. The studies take advantage of a unique opportunity to look at the effects of space travel on identical twins, one of whom experiences space travel for one year while the other is earth-bound. The study looks at changes in the human body in the fields of genetics, psychology, physiology, microbiology, and immunology.

Rodent Research-2 Preparations: Cristoforetti completed a Bone Densitometer checkout in advance of Sunday’s final sample collection for the RR-2 experiment. This research is to monitor the effects of the space environment on the musculoskeletal and neurological systems of mice as model organisms of human health and disease. Living in microgravity results in significant and rapid effects on the physiology of mice that mimic the process of aging and some diseases in humans on Earth, including muscle atrophy and the loss of bone mineral density.

Extravehicular Mobility Unit (EMU) 3010 Fan Pump Separator (FPS) Prep for Return: Following the successful Remove & Replace (R&R) of the failed FPS in EMU 3010 this week, today the crew packed the removed FPS for return on 41 Soyuz (41S). A Return To Service test for the suit is planned next week.

Robotics Operations: Today, the Robotics Ground Controllers powered up the Mobile Servicing System (MSS) and maneuvered the Space Station Remote Manipulator System (SSRMS) into position to complete a survey the multi-layer insulation (MLI) on the ammonia lines. They then maneuvered SSRMS in a survey of the Russian segment in order to support updates to the models used for robotic planning on the ground.

Today’s Planned Activities
All activities were completed unless otherwise noted.

• TWIN. Sample Collection
• SLEEP. Completing Questionnaire
• HRF – Sample Collection and Prep for Stowage
• HRF – Sample MELFI Insertion
• SLEEP. Completing Questionnaire
• HRF – Sample MELFI Insertion
• PK-4 data hard drives exchange for the next experiment run
• HRF1 – Installation of PC1
• ISS crew and ГОГУ (RSA Flight Control Management Team) weekly conference
• РК4 Experiment Ops
• RGN-REC TNK – Transfer and Swap
• Fine Motor Skills – Subject
• PK4 Run 3 [Aborted]
• Video camera GoPro HERO3 setup and adjustment for ТК 715 Descent Ops
• Food Frequency Questionnaire
• OTKLIK. Hardware Check
• Rodent Research (RR) – Review
• WRS – Recycle Tank Fill
• PAO hardware setup
• CDM Data Download to SSC Laptop
• Crew Prep for PAO
• Charging GoPro HERO3 Camcorder Battery – start
• HRF Rack 1 – Ultrasound 2 Hardware Setup
• PAO Event During A Year-Long Mission
• WRS – Recycle Tank Fill [Aborted]
• HRF Rack 1 – Ultrasound 2 Hardware Power On
• CARDOX – Preparation Steps and Hardware Setup
• WRS – Recycle Tank Fill
• RELAKSATSIYA. Hardware Setup
• ТК 715 Stowage Ops for Disposal and Return
• CARDOX – Experiment Ops
• RELAKSATSIYA. Setting Parameters
• CARDOX – Battery Installation into Holter Arterial BP unit
• CARDOX – Blood Pressure Operations
• Rodent Research Module: Water Box and Light Check
• RELAKSATSIYA Observation
• CARDOX – Blood Pressure Operations Closeout
• Food Frequency Questionnaire
• RELAKSATSIYA Closeout Ops
• Removal of depress hose for nominal operations
• Rodent Research (RR) – Review
• РК4 Chamber Cleaning
• Private Exercise Conference (PEC)
• Charging GoPro HERO3 Camcorder Battery – end
• WRS – Recycle Tank Fill
• Replacement of RSE1 Laptop Shell.
• EDV (SV) Filling (Separation)
• FLUID SHIFTS. OCT Setup in USOS
• ТК 715 Stowage Ops for Disposal and Return
• Fan Pump Separator (FPS) Pack for Return
• Ultrasound – Data Export
• RGN – Initiate drain into EDV
• FLUID SHIFTS. Equipment stowage
• ESA Weekly Crew Conference
• СОЖ Maintenance
• RGN – Terminate water drain into EDV
• Transfer of Fan Pump Separator (FPS)
• IMS and Stowage Conference
• LBNP Exercise (PRELIMINARY)
• IMS Delta File Prep
• Crew Departure Prep
• USND2 – Deactivation of Ultrasound Hardware and Camcorder
• Rodent Research (RR) – Camcorder Setup
• Crew Discretionary Conference
• Flight Director / ISS Crew Tagup
• PK4 Gas Exchange in the Chamber to Neon
• PK4 Hardware Teardown

Completed Task List Items

• WHC-KTO-REPLACE
• JLP-BAG-RESTOW

Ground Activities
All activities were completed unless otherwise noted.

• MSS survey ops
• CDH Bus Ch B Swap
• CDH Bus Ch A Swap

Three-Day Look Ahead:

• Saturday, 06/06: Crew off duty, housekeeping
• Sunday, 06/07: Rodents Research CASIS session
• Monday, 06/08: Rodents Research fixative swap, OBT Soyuz drill, Emergency roles/responsibilities review

QUICK ISS Status – Environmental Control Group:

Component	Status
Elektron	Off
Vozdukh	Manual
[СКВ] 1 – SM Air Conditioner System (“SKV1”)	On
[СКВ] 2 – SM Air Conditioner System (“SKV2”)	Off
Carbon Dioxide Removal Assembly (CDRA) Lab	Standby
Carbon Dioxide Removal Assembly (CDRA) Node 3	Operate
Major Constituent Analyzer (MCA) Lab	Shutdown
Major Constituent Analyzer (MCA) Node 3	Operate
Oxygen Generation Assembly (OGA)	Process
Urine Processing Assembly (UPA)	Standby
Trace Contaminant Control System (TCCS) Lab	Off
Trace Contaminant Control System (TCCS) Node 3	Full Up