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Jared Broddrick

Jared Broddrick

Systems Biologist

Email: jared.t.broddrick@nasa.gov
Affiliation: Space Biosciences Research Branch

Professional Background

Biography

  • 2020-Present: Research Aerospace Technologist, Biological Studies, Space Biosciences Research Branch, NASA’s Ames Research Center, Moffett Field, CA
  • 2018-2020: NASA Postdoctoral Fellow (administered by USRA), Exobiology Branch, NASA’s Ames Research Center, Moffett Field, CA
  • 2012-2018: Graduate Researcher, Systems Biology Research Group, University of California San Diego, La Jolla, CA
  • 2010-2012: Associate Scientist, Gilead Sciences, Oceanside, CA
  • 2006-2010: Research Associate, Genentech Inc., Oceanside, CA

Education

  • 2018: Ph.D. in Biological Sciences, University of California San Diego
  • 2005: M.Sc in Biochemistry, University of California San Diego
  • 2002: B.S. in Biochemistry, United States Air Force Academy, Distinguished Graduate

Research Interests

Dr. Broddrick is a systems biologist in the Space Biosciences Research Branch at NASA Ames Research Center. His research efforts combine omics datasets and mathematical models to derive a mechanistic understanding of microbial physiology in the space environment. Understanding how the spaceflight environment constrains microbial networks is relevant to outstanding questions in the areas of human health in the exploration of space (e.g. microbiome, bacterial pathogenicity, etc.), bioengineering solutions to long-duration spaceflight, and the adaptation of microbial organisms to spacecraft environments.

Dr. Broddrick is currently supporting several research investigations in the fields of space biology, astrobiology and planetary protection. He also serves as the Microbiology Discipline Scientist for the Space Biology Program.

Publications

  1. Broddrick, J.T., Ware, M.A., Jallet, D., Palsson, B.O. and Peers, G. (2022), Integration of physiologically relevant photosynthetic energy flows into whole genome models of light-driven metabolism. Plant J, 112: 603-621. https://doi.org/10.1111/tpj.15965.
  2. Kiang, N.Y.; Swingley, W.D.; Gautam, D.; Broddrick, J.T.; Repeta, D.J.; Stolz, J.F.; Blankenship, R.E.; Wolf, B.M.; Detweiler, A.M.; Miller, K.A.; Schladweiler, J.J.; Lindeman, R.; Parenteau, M.N. (2022). Discovery of Chlorophyll d: Isolation and Characterization of a Far-Red Cyanobacterium from the Original Site of Manning and Strain (1943) at Moss Beach, California. Microorganisms, 10, 819. https://doi.org/10.3390/microorganisms10040819.
  3. Broddrick J.T., Szubin R, Norsigian CJ, Monk JM, Palsson BO and Parenteau MN (2020) High-Quality Genome-Scale Models From Error-Prone, Long-Read Assemblies. Front. Microbiol. 11:596626. doi: 10.3389/fmicb.2020.596626
  4. Smith S.R., C.L. Dupont, J.K. McCarthy, J.T. Broddrick, M. Obornik, A. Horak, J. Cihlar, S. Kleesen, H. Zheng, J.P. McCrow, K.K. Hixson, W.L. Araujo, A. Nunes-Nesi, A. Fernie, Z. Nikoloski, B.O.Palsson, and A.E. Allen (2019). “Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom.” Nat Commun 10, 4552
  5. Broddrick J.T.*, N. Du*, S.R. Smith, Y. Tsuji, D. Jallet, M.A. Ware, G. Peers, Y. Matsuda, C.L. Dupont, B.G.Mitchell, B.O. Palsson and A.E. Allen (2019). “Cross-compartment metabolic coupling enables flexible photoprotective mechanisms in the diatom Phaeodactylum tricornutum.” New Phytologist 222(3): 1364-1379
  6. Yang, L., N. Mih, A. Anand, J. H. Park, J. Tan, J.T. Yurkovich, J.M. Monk, C.J. Lloyd, T.E. Sandberg, S.W. Seo, D. Kim, A.V. Sastry, P. Phaneuf, Y. Gao, J.T. Broddrick, K. Chen, D. Heckmann, R. Szubin, Y. Hefner, A.M. Feist and Be.O. Palsson (2019). “Cellular responses to reactive oxygen species are predicted from molecular mechanisms.“ Proceedings of the National Academy of Sciences, 116 (28) 14368-14373.
  7. Seif, Y., J.M. Monk, N. Mih, H. Tsunemoto, S. Poudel, C. Zuniga, J. Broddrick, K. Zengler and B.O. Palsson (2019). “A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types.” PLoS Comput Biol 15(1): e1006644.
  8. Broddrick J.T., D.G. Welkie, D. Jallet, S.S. Golden, G. Peers and B.O. Palsson (2019). “Predicting the metabolic capabilities of Synechococcus elongatus PCC 7942 adapted to different light regimes.” Metab Eng, 52:42-56.
  9. Yurkovich J.T., D.C. Zielinski, L. Yang, G. Paglia, O. Rolfsson, O.E. Sigurjónsson, J.T. Broddrick, A. Bordbar, K. Wichuk, S. Brynjólfsson, S. Palsson, S. Gudmundsson and B.O. Palsson (2017). “Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networks” Journal of Biological Chemistry 292(48): 19556-19564.
  10. Broddrick J.T.*, B.E. Rubin*, D.G. Welkie*, N. Du, N. Mih, S. Diamond, J. J. Lee, S.S. Golden, and B.O. Palsson (2016). “Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis.” Proceedings of the National Academy of Sciences 113 (51): E8344-E8353.
  11. Levering, J., J. Broddrick, C.L. Dupont, K. Beeri, J. Mayers, A.A. Gallina, A.E. Allen, B.O. Palsson, and K. Zengler (2016). “Genome-scale model reveals metabolic basis of biomass partitioning in a model diatom.” PLoS ONE 11(5): e0155038.
  12. Levering, J., J. Broddrick and K. Zengler (2015). “Engineering of oleaginous organisms for lipid production.” Current opinion in biotechnology 36: 32-39.
  13. Derfus, G. E., J. Dizon-Maspat, J. T. Broddrick, A. C. Velayo, J. D. Toschi, R. T. Santuray, S. K. Hsu, C. M. Winter, R. Krishnan and A. Amanullah (2014). “Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest.” mAbs 6(3): 679-688.

* These authors contributed equally

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