Santiago, Chile, the South American nation’s capital and largest city

iss073e0381336 (July 18, 2025) --- Santiago, Chile, the South American nation's capital and largest city with a metropolitan population of over 6.9 million, is pictured at approximately 4:57 a.m. local time from the International Space Station as it orbited 266 miles above. Santiago rests in the Chilean Central Valley in between the Andes Mountains and the Chilean Coastal Range on the Pacific coast.