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OSDR Enabled Publications – 91

Title Description Datasets
Celebrating 30 years of access to NASA Space Life Sciences data Sanders L M, Lopez D K, Wood A E, Scott R T, Gebre S G, Saravia-Butler A M, and Costes S V, (2024). Celebrating 30 years of access to NASA Space Life Sciences data, GigaScience. DOI: 10.1093/gigascience/giae066
Transcriptional response of Arabidopsis thaliana’s root-tip to spaceflight Shahbazi M, Rutter L A, Barker R, (2024). Transcriptional response of Arabidopsis thaliana’s root-tip to spaceflight, Plant Molecular Biology. DOI: 10.1007/s11103-024-01478-1 OSD-120
Spaceflight alters host-gut microbiota interactions Gonzalez E, Lee M D, Tierney B T, Lipieta N, Flores P, Mishra M, Beckett L, et al, (2024). Spaceflight alters host-gut microbiota interactions, npj biofilms and microbiomes. https://doi.org/10.1038/s41522-024-00545-1 OSD-245, OSD-247, OSD-249
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegans He X, Zhao L, Huang B, Zhang G, Lu Y, Mi D, Sun Y, (2024). Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegans, Life Sciences in Space Research. https://doi.org/10.1016/j.lssr.2024.07.001 OSD-75, OSD-112
Fungal diversity differences in the indoor dust microbiome from built environments on earth and in space Nastasi M, Haines S R, Bope A, Meyer M E, Horack J M, Dannemiller K C, (2024). Fungal diversity in the indoor dust microbiome from built environments on earth and in space, Scientific Reports. doi: 10.1038/s41598-024-62191-z OSD-694
Aging and putative frailty biomarkers are altered by spaceflight Camera A, Tabetah M, Castaneda V, Kim J, Galsinh A S, Haro-Vinueza A, Salinas I, et al, (2024). Aging and putative frailty biomarkers are altered by spaceflight, Scientific Reports. doi: 10.1038/s41598-024-57948-5 OSD-21, OSD-52, OSD-99, OSD-101, OSD-103, OSD-104, OSD-105, OSD-195, OSD-202
Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions Zhang Y, Du X, Zhao L, Sun Y, (2024). Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions, International Journal of Radiation Biology. doi.org/10.1080/09553002.2024.2327393
Cosmic kidney disease: An integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction Siew K, Nestler K A, Nelson C, D’Ambrosio V, Zhong C, Li Z, Grillo A, et al, (2024). Cosmic kidney disease: An integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction, Nature Communications. doi: 10.1038/s41467-024-49212-1 OSD-72, OSD-102, OSD-163, OSD-212, OSD-249, OSD-250, OSD-253, OSD-336, OSD-342, OSD-457, OSD-462, OSD-465, OSD-466, OSD-513, OSD-530, OSD-532, OSD-571, OSD-575, OSD-706, OSD-707, OSD-708, OSD-709, OSD-710, OSD-712
Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes Ilangovan H, Kothiyal P, Hoadley K A, Elgart R, Eley G, Eslami P, (2024). Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes, npj microgravity. doi: 10.1038/s41526-024-00379-3 OSD-47, OSD-168, OSD-242, OSD-245, OSD-379
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight Houerbi N, Kim J, Overbey E G, Batra R, Schweickart A, Patras L, Lucotti S, et al, (2024). Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight, Communications Medicine. doi: 10.1038/s41467-024-48841-w OSD-530, OSD-569, OSD-571
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight Wu F, Du J, Overbey E, Kim J, Makhijani P, Martin N, Lerner C A, et al, (2024). Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight, Nature Communications. doi: 10.1038/s41467-023-42013-y OSD-420
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight Kim J, Tierney B T, Overbey E G, Dantas E, Fuentealba M, Park J, Narayanan S A, et al, (2024). Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight, Nature Communications. doi: 10.1038/s41467-024-49211-2 OSD-530, OSD-570, OSD-575
Space radiation damage rescued by inhibition of key spaceflight-associated miRNAs McDonald J T, Kim J, Farmerie L, Johnson M L, Trovao N S, Arif S, Siew K, et al, (2024). Space radiation damage rescued by inhibition of key spaceflight-associated miRNAs, Nature Communications. doi: 10.1038/s41467-024-48920-y OSD-334, OSD-335, OSD-336, OSD-337, OSD-530, OSD-570, OSD-577
Spaceflight induces changes in gene expression profiles linked to insulin and estrogen Mathyk B A, Tabetah M, Karim R, Zaksas V, Kim J, Anu R I, Muratani M, et al, (2024). Spaceflight induces changes in gene expression profiles linked to insulin and estrogen, Communications Biology. doi: 10.1038/s42003-023-05213-2 OSD-48, OSD-98, OSD-99, OSD-100, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-168, OSD-238, OSD-239, OSD-240, OSD-241, OSD-254, OSD-530
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice Masarapu Y, Cekanaviciute E, Andrusivova Z, Westholm J O, Bjorklund A, Fallegger R, Badia-i-Mompel P, et al (2024). Spatially resolved multiomics on the neuronal effects <mark>induced by spaceflight in mice, Nature C<mark>ommunications.m> doi: 10.1038/s41467-024-48916-8 GLDS-352 
Spatiotemporal expression and control of haemoglobin in space Borg J, Loy C, Kim J, Buhagiar A, Chin C, Damle N, De Vlaminck I, et al, (2024). Spatiotemporal expression and control of haemoglobin in space, Nature Communications. doi: 10.1038/s41467-024-49289-8 OSD-530, OSD-570
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology Cope H, Elsborg J, Demharter S, McDonald J T, Wernecke C, Parthasarathy H, Unadkat H, et al, (2024). Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology, Communications Medicine. doi: 10.1038/s43856-024-00532-9 OSD-238, OSD-239, OSD-240, OSD-241, OSD-254
Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis Hauserman M R, Ferraro M J, Carroll R K, Rice K C, (2024). Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis, npj Microgravity. doi: 10.1038/s41526-023-00343-7 OSD-145, OSD-500
Analysis of the influence of microgravity and space radiation on astronauts’ gene expression: An approach using quantum simulations and fuzzy logic Vargas Cruz M A, (2024). Analysis of the influence of microgravity and space radiation on astronauts’ gene expression: An approach using quantum simulations and fuzzy logic, Precis. Nanomed. doi.org/10.33218/001c.117460 OSD-530
Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation Perdyan A, Jakalski M, Horbacz M, Beheshti A, Mieczkowski J, (2024). Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation, Scientific Reports. doi: 10.1038/s41598-024-51756-7 OSD-80, OSD-109, OSD-117, OSD-159, OSD-203, OSD-294, OSD-317, OSD-530
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight Samson F, Bhat A, Sayyah Z, Reinsch S, Blaber E, (2024). Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight, Gravitational and Space Research. DOI: 10.2478/gsr-2024-0002 OSD-207
Feature engineering from meta-data for prediction of differentially expressed genes: An investigation of Mus musculus exposed to space-conditions Okwori M and Eslami A, (2024). Feature engineering from meta-data for prediction of differentially expressed genes: An investigation of Mus musculus exposed to space-conditions, Computational Biology and Chemistry. doi.org/10.1016/j.compbiolchem.2024.108026 OSD-47, OSD-98, OSD-100, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-168, OSD-242
Gut permeability among Astronauts during Space missions Akinsuyi O S, Xhumari J, Ojeda A, Roesch L F W, (2024). Gut permeability among Astronauts during Space missions, Life Sciences Space Research. doi.org/10.1016/j.lssr.2024.03.003 OSD-247, OSD-249, OSD-466, OSD-530, OSD-667
Inspiration4 data access through the NASA Open Science Data Repository Sanders L M, Grigorev K A, Scott R T, Saravia-Butler A M, Polo S L, Gilbert R, Overbey E G, et al, (2024). Inspiration4 data access through the NASA Open Science Data Repository, npj microgravity. doi.org/10.1038/s41526-024-00393-5 OSD-569, OSD-569, OSD-570, OSD-570, OSD-571, OSD-571, OSD-572, OSD-572, OSD-573, OSD-573, OSD-574, OSD-574, OSD-575, OSD-575, OSD-630, OSD-630, OSD-656, OSD-656, OSD-687, OSD-687
NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions Adamopoulos K I, Sanders L M, Costes S V, (2024). NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions, npj microgravity. doi.org/10.1038/s41526-024-00392-6 OSD-4, OSD-5, OSD-13, OSD-18, OSD-21, OSD-25, OSD-29, OSD-30, OSD-32, OSD-33, OSD-48, OSD-50, OSD-51, OSD-52, OSD-54, OSD-55, OSD-56, OSD-61, OSD-63, OSD-107, OSD-111, OSD-114, OSD-116, OSD-118, OSD-124, OSD-125, OSD-128, OSD-129, OSD-135, OSD-172, OSD-174, OSD-188, OSD-189, OSD-195, OSD-198, OSD-227, OSD-232, OSD-283, OSD-297, OSD-324, OSD-370, OSD-396, OSD-484, OSD-536, OSD-545, OSD-546, OSD-547
Substrate Matters: Ionic Silver Alters Lettuce Growth, Nutrient Uptake, and Root Microbiome in a Hydroponics System Spencer L, Costine B, Irwin T, Dixit A, Spern C, Diaz A, Lozzi B, (2024). Substrate Matters: Ionic Silver Alters Lettuce Growth, Nutrient Uptake, and Root Microbiome in a Hydroponics System, microorganisms. doi.org/10.3390/microorganisms12030515
Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice Zhang Y, Zhao L, Sun Y, (2024). Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice, npj microgravity. doi.org/10.1038/s41526-024-00383-7 OSD-47, OSD-98, OSD-99, OSD-100, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-137, OSD-162, OSD-163, OSD-164, OSD-168, OSD-173, OSD-194, OSD-238, OSD-240, OSD-241, OSD-242, OSD-243, OSD-244, OSD-245, OSD-246, OSD-247, OSD-248, OSD-253, OSD-288, OSD-379, OSD-401, OSD-546
Batch effect correction methods for NASA GeneLab transcriptomic datasets Sanders L M, Chok H, Samson F, Acuna A U, Polo S H L, Boyko V, Chen Y C, et al (2023). Batch effect correction methods for NASA GeneLab transcriptomic datasets, Frontiers in Astronomy and Space Sciences. doi: 10.3389/fspas.2023.1200132 OSD-47, OSD-48, OSD-137, OSD-168, OSD-173, OSD-242, OSD-245
Designing a Novel Monitoring Approach for the Effects of Space Travel on Astronauts’ Health Sakharkar A and Yang J, (2023). Designing a novel monitoring approach for the effects of space travel on astronauts’ health, Life. doi.org/10.3390/life13020576 OSD-174
Efficacy of the random positioning machine as a terrestrial analogue to microgravity in studies of seedling phototropism Hughes A M, Vandenbrink J P, and Kiss J Z, (2023). Efficacy of the random positioning machine as a terrestrial analogue to microgravity in studies of seedling phototropism, Microgravity Science and Technology. doi: 10.1007/s12217-023-10066-9 OSD-251
Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice Li K, Desai R, Scott R T, Steele J R, Machado M, Demharter S, Hoarfrost A, et al (2023). Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice, npj Microgravity. doi: 10.1038/s41526-023-00337-5 OSD-104, OSD-104, OSD-105, OSD-105, OSD-488, OSD-488
Functional Meta-Analysis of the Proteomic Responses of Arabidopsis Seedlings to the Spaceflight Environment Reveals Multi-Dimensional Sources of Variability across Spaceflight Experiments Olanrewaju G O, Kruse C P S, and Wyatt S E, (2023). Functional Meta-Analysis of the Proteomic Responses of Arabidopsis Seedlings to the Spaceflight Environment Reveals Multi-Dimensional Sources of Variability across Spaceflight Experiment, International Journal of Molecular Sciences. doi.org/10.3390/ijms241914425 OSD-38, OSD-522
Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model Cahill T, da Silveira W A, Renaud L, Wang H, Williamson T, Chung D, Chan S, et al, (2023). Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model, Scientific Reports. doi.org/10.1038/s41598-022-26976-4 OSD-47
Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination Sadaki S, Fujita R, Hayashi T, Nakamura A, Okamura Y, Fuseya S, Hamada M, et al, (2023). Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination, Cell Reports. doi.org/10.1016/j.celrep.2023.112289 OSD-104
Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome Barker R, Kruse C P S, Johnson C, Saravia-Butler A, Fogle H, Chang H S, Trane R M, et al (2023). Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome, npj Microgravity. doi.org/10.1038/s41526-023-00247-6 OSD-7, OSD-17, OSD-37, OSD-38, OSD-44, OSD-46, OSD-120, OSD-121, OSD-136, OSD-147, OSD-205, OSD-208, OSD-213, OSD-218, OSD-251
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent Malhan D, Yalçin M, Schoenrock B, Blottner D, and Relógio A, (2023). Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent, npj Microgravity. doi.org/10.1038/s41526-023-00273-4 OSD-99, OSD-101, OSD-103, OSD-104, OSD-105, OSD-370
Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments Çelen I, Jayasinghe A, Doh J H, and Sabanayagam C R, (2023). Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments, Cells. doi.org/10.3390/cells12020270 OSD-41, OSD-42, OSD-112, OSD-113
A multi omics longitudinal study of the murine retinal response to chronic low dose irradiation and simulated microgravity Kothiyal P, Eley G, Ilangovan H, Hoadley K A, Elgart S R, Mao X W, and Eslami P (2022). A multi omics longitudinal study of the murine retinal response to chronic low dose irradiation and simulated microgravity, Scientific Reports. doi.org/10.1038/s41598-022-19360-9 OSD-203
Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight Overbey E G, Das S, Cope H, Madrigal P, Andrusivova Z, Frapard S, Klotz R, et al, (2022). Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight, Cell Reports Methods. doi.org/10.1016/j.crmeth.2022.100325 OSD-402, OSD-403, OSD-404, OSD-405
Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight Manian V, Orozco-Sandoval J, Diaz-Martinez V, Janwa H, and Agrinsoni C, (2022). Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight, Genes. doi.org/10.3390/genes13030473 OSD-21, OSD-99, OSD-101, OSD-103, OSD-104, OSD-111, OSD-135
DNA methylation dynamics associated with long-term isolation of simulated space travel Hou F, Zhou X, Zhou S, Liu H, Huang Y E, Yuan M, Zhu J, et al (2022). DNA methylation dynamics associated with long-term isolation of simulated space travel, iScience. doi: 10.1016/j.isci.2022.104493. OSD-140
Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review Drago-Ferrante R, Di Fiore R, Karouia F, Subbannayya Y, Das S, Mathyk B A, Arif S, et al (2022). Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review, Int. J. Mol. Sci. doi: https://doi.org/ 10.3390/ijms23137465
In Vitro Relationships of Galactic Cosmic Radiation and Epigenetic Clocks in Human Bronchial Epithelial Cells Nwanaji-Enwerem J C, Boileau P, Galazka J M, (2022). In Vitro Relationships of Galactic Cosmic Radiation and Epigenetic Clocks in Human Bronchial Epithelial Cells, Environmental and Molecular Mutagenesis. doi.org/10.1002/em.22483 OSD-317
Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Madrigal P, Singh N K, Wood J M, Gaudioso E, Hernández del Olmo F, Mason C E, Venkateswaran K, and Beheshti A, (2022). Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome, Microbiome. doi.org/10.1186/s40168-022-01332-w OSD-67, OSD-69, OSD-302, OSD-303, OSD-309, OSD-311, OSD-350
Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station. Tierney B T, Singh N K, Simpson A C, Hujer A M, Bonomo R A, Mason C E, and Venkateswaran K, (2022). Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station, Microbiome. doi.org/10.1186/s40168-022-01358-0 OSD-252
Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice Vitry G, Finch R, Mcstay G, Behesti A, De jean S, Larose T, Wotring V, et al (2022). Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice, iScience. doi.org/10.1016/j.isci.2022.105213 OSD-103, OSD-168
Omics studies of plant biology in spaceflight: A critical review of recent experiments Hughes A M and Kiss J Z (2022). Omics studies of plant biology in spaceflight: A critical review of recent experiments, Frontiers in Astronomy and Space Sciences. doi.org/10.3389/fspas.2022.964657 OSD-7, OSD-120
Plant Space Biology in the Genomics Age Meyers A and Wyatt S E, (2022). Plant Space Biology in the Genomics Age, Annual Plant Reviews. doi:10.1002/9781119312994.apr0784 OSD-7, OSD-8, OSD-16, OSD-17, OSD-22, OSD-37, OSD-38, OSD-44, OSD-45, OSD-46, OSD-57, OSD-59, OSD-120, OSD-121, OSD-134, OSD-136, OSD-144, OSD-147, OSD-193, OSD-205, OSD-208, OSD-210, OSD-213, OSD-217, OSD-218, OSD-219, OSD-220, OSD-223, OSD-251, OSD-267, OSD-268, OSD-269, OSD-281, OSD-282, OSD-284, OSD-296, OSD-301, OSD-307, OSD-313, OSD-314, OSD-320, OSD-321, OSD-329, OSD-346, OSD-375
Recent transcriptomic studies to elucidate the plant adaptive response to spaceflight and to simulated space environments Manzano A, Carnero-Diaz E, Herranz R, and Medina F J, (2022). Recent transcriptomic studies to elucidate the plant adaptive response to spaceflight and to simulated space environments, iScience. doi.org/10.1016/j.isci.2022.104687 OSD-7, OSD-8, OSD-17, OSD-37, OSD-38, OSD-44, OSD-120, OSD-121, OSD-144, OSD-147, OSD-205, OSD-213, OSD-217, OSD-218, OSD-220, OSD-223, OSD-251, OSD-284, OSD-313, OSD-314, OSD-321, OSD-416, OSD-427
Reducing virus infection risk in space environments through nutrient supplementation Li H, Xue Y W, Quan Y, and Zhang H Y, (2022). Reducing virus infection risk in space environments through nutrient supplementation, Genes. doi.org/10.3390/genes13091536 OSD-140
Space omics research in Europe: contributions, geographical distribution and ESA member state funding schemes Deane C S, Borg J, Cahill T, Carnero-Diaz E, Etheridge T, Hardiman G, Leys N, (2022). Space omics research in Europe: contributions, geographical distribution and ESA member state funding schemes, iScience. https://doi.org/10.1016/j.isci.2022.103920
An integrative network science and artificial intelligence drug repurposing approach for muscle atrophy in spaceflight microgravity. Manian V, Orozco-Sandoval J, and Diaz-Martinez V, (2021). An integrative network science and artificial intelligence drug repurposing approach for muscle atrophy in spaceflight microgravity, Frontiers in Cell and Developmental Biology. doi: 10.3389/fcell.2021.732370 OSD-4, OSD-244, OSD-245, OSD-246, OSD-288, OSD-289
Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight Manian V, Orozco-Sandoval J, and Diaz-Martinez V, (2021). Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight, Genes. doi.org/10.3390/genes12060938 OSD-7, OSD-37, OSD-38, OSD-46, OSD-120
Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity Paul A M, Overbey E G, da Silveira W A, Szewczyk N, Nishiyama N C, Pecaut M J, Anand S, et al, (2021). Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity, Scientific Reports. doi.org/10.1038/s41598-021-9043
Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases Nelson, C.A., Acuna, A.U., Paul, A.M., Scott, R.T., Butte, A.J., Cekanaviciute, E, Baranzini, S.E., and Costes, S.V., (2021). Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases, Life. doi.org/10.3390/life11010042 OSD-4, OSD-244, OSD-245, OSD-246, OSD-288, OSD-289
Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight Cahill T, Cope H, Bass J J, Overbey E G, Gilbert R, da Silveira W A, Paul A M, et al (2021). Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight, International Journal of Molecular Sciences. doi.org/10.3390/ijms22179470 OSD-3, OSD-21, OSD-99, OSD-103, OSD-104, OSD-113, OSD-370
NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data Overbey E G, Saravia-Butler A M, Zhang Z, Rathi K S, Fogle H, da Silveira W A, Barker R J, et al, (2021). NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data, iScience. doi.org/10.1016/j.isci.2021.102361 OSD-168, OSD-245
Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity Manian, V., Orozco, J., Gangapuram, H., Janwa, H., and Agrinsoni, C., (2021). Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity, Genes. doi.org/10.3390/genes12030337 OSD-7, OSD-120
Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures Barker R, Costes SV, Miller J, Gebre SG, Lombardino J, Gilroy S, (2021). Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures, NPJ Microgravity. doi.org/10.1038/s41526-021-00143-x OSD-4, OSD-7, OSD-16, OSD-17, OSD-25, OSD-33, OSD-41, OSD-44, OSD-50, OSD-54, OSD-58, OSD-59, OSD-61, OSD-62, OSD-72, OSD-75, OSD-83, OSD-87, OSD-95, OSD-96, OSD-108, OSD-112, OSD-116, OSD-120, OSD-121, OSD-133, OSD-147, OSD-205, OSD-207, OSD-213, OSD-223, OSD-243, OSD-244, OSD-245, OSD-246, OSD-247, OSD-248, OSD-249
Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement Brereton N J B, Pitre F E, Gonzalez E., (2021). Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement, Computational and Structural Biotechnology Journal. doi.org/10.1016/j.csbj.2021.03.040 OSD-191
A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission Nwanaji-Enwerem, J. C., Nwanaji-Enwerem, U., Van Der Laan, L., Galazka, J. M., Redeker, N. S., and Cardenas, A., (2020). A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission, Cell Reports. doi.org/0.1016/j.celrep.2020.108406 OSD-140
A New Era for Space Life Science: International Standards for Space Omics Processing Rutter, L., Barker, R., Bezdan, D., Cope, H., Costes, S. V., Degoricija, L., Fisch, K. M., et al., (2020). A New Era for Space Life Science: International Standards for Space Omics Processing, Patterns. doi.org/10.1016/j.patter.2020.100148
Advancing the Integration of Biosciences Data Sharing to Further Enable Space Exploration Scott, R.T., Grigorev, K., Mackintosh, G., Gebre, S. G., Mason, C. E., Del Alto, M. E., and Costes, S. V., (2020). Advancing the Integration of Biosciences Data Sharing to Further Enable Space Exploration, Cell Reports. doi.org/10.1016/j.celrep.2020.108441
Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans Willis, C. R. G., Szewczyk, N. J., Costes, S. V., Udranszky, I. A., Reinsch, S. S., Etheridge, T., and Conley, C. A., (2020). Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans, iScience. doi.org/10.1016/j.isci.2020.101734 OSD-41, OSD-112, OSD-113, OSD-190
Comparisons of Transcriptome Profiles from Bacillus subtilis Cells Grown in Space versus High Aspect Ratio Vessel (HARV) Clinostats Reveal a Low Degree of Concordance Morrison, Michael D., Nicholson, Wayne L. “Comparisons of Transcriptome Profiles from Bacillus subtilis Cells Grown in Space versus High Aspect Ratio Vessel (HARV) Clinostats Reveal a Low Degree of Concordance. Astrobiology 2020, doi.org/10.1089/ast.2020.2235 OSD-31, OSD-39, OSD-14, OSD-15
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., et al., (2020). Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact, Cell. doi.org/10.1016/j.cell.2020.11.002 OSD-98, OSD-99, OSD-100, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-161, OSD-162, OSD-163, OSD-168, OSD-13, OSD-52, OSD-54, OSD-114, OSD-118, OSD-174, OSD-47, OSD-48, OSD-343
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration Afshinnekoo, E., Scott, R. T., MacKay, M. J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., et al., (2020). Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration, Cell. doi.org/10.1016/j.cell.2020.10.050
Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight Fujita, S-I, Rutter, L., Ong, Q., Muratani, M. (2020). Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight. Life 2020, 10(9), 196; doi.org/10.3390/life10090196 OSD-98,, OSD-99, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-168, OSD-48
MicroRNAs (miRNAs), the final frontier: The hidden master regulators impacting biological responses in all organisms due to spaceflight Vandenburg, C., Beheshti, A. (2020). MicroRNAs (miRNAs), the final frontier: The hidden master regulators impacting biological responses in all organisms due to spaceflight. The Health Risks of Extraterrestrial Environments, March 9, 2020.
NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models McDonald, T. J., Stainforth, R., Miller, J., Cahill, T., da Silveira, W. A., Rathi, K. S., Hardiman, G., Taylor, D., Costes, S. V., Chauhan, V., Meller, R., Beheshti, A. (2020). NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers 2020, 12(2), 381; doi.org/10.3390/cancers12020381 (registering DOI). OSD-63, OSD-52, OSD-114, OSD-21, OSD-4, OSD-47, OSD-25, OSD-98, OSD-99, OSD-100, OSD-101, OSD-102, OSD-103, OSD-104, OSD-105, OSD-168, OSD-242,, OSD-161, OSD-162, OSD-163, OSD-168, OSD-61, OSD-111, OSD-80, OSD-109, OSD-73, OSD-117
NASA GeneLab: interfaces for the exploration of space omics data Berrios D C, Galazka J, Grigorev K, Gebre S, and Costes S V, (2020). NASA GeneLab: interfaces for the exploration of space omics data, Nucleic Acids Research. doi: 10.1093/nar/gkaa887
Revamping Space-omics in Europe Madrigal, P., Gabel, A., Villacampa, A., Manzano, A., Deane, C. S., Bezdan, D., Carnero-Diaz, E., et al., (2020). Revamping Space-omics in Europe, Cell Systems. doi.org/10.1016/j.cels.2020.10.006
RNAseq Analysis of Rodent Spaceflight Experiments Is Confounded by Sample Collection Techniques Polo, S. L., Saravia-Butler, A. M., Boyko, V., Dinh, M. T., Chen, Y., Fogle, H., Reinsch, S. S., et al., (2020). RNAseq Analysis of Rodent Spaceflight Experiments Is Confounded by Sample Collection Techniques, iScience. doi.org/10.1016/j.isci.2020.101733 OSD-47, OSD-48, OSD-49, OSD-168, OSD-235, OSD-236
Test of Arabidopsis Space Transcriptome: A Discovery Environment to Explore Multiple Plant Biology Spaceflight Experiments Barker, R., Rasmussen, K., Gilroy, S. (2020). Test of Arabidopsis Space Transcriptome: A Discovery Environment to Explore Multiple Plant Biology Spaceflight Experiments, Frontiers Plant Science, 2020. Mar 4;11:147. doi.org/10.3389/fpls.2020.00147. eCollection 2020. OSD-7, OSD-8, OSD-16, OSD-17, OSD-22, OSD-37, OSD-38, OSD-44, OSD-47, OSD-120, OSD-121, OSD-14, OSD-144, OSD-147, OSD-205, OSD-208, OSD-213, OSD-217, OSD-251
Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation Choi, S.Y., Saravia-Butler, A., Shirazi-Fard, Y., Levenson-Gower, D., Stodieck, L. S., Cadena, S. M., Beege, J., Solis, S., Ronca, A., Globus, R. K. (2020). Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation. Sci Rep 10, 2336 (2020). doi.org/10.1038/s41598-020-58898-4 OSD-48
Visualizing Omics Data from Spaceflight Samples using the NASA GeneLab Platform Berrios, D., Weitz, E., Grigorev, K., Costes, S.V., Gebre, S. G., Beheshti, A. 2020, Visualizing Omics Data from Spaceflight Samples using the NASA GeneLab Platform, EPiC Series in Computing, vol 70, pages 89–98, doi.org/10.29007/rh7n
Comparison of Bacillus subtilis transcriptome profiles from two separate missions to the International Space Station Morrison, D., Fajardo-Cavozos, P., Nicholson, W. L., (2019). Comparison of Bacillus subtilis transcriptome profiles from two separate missions to the International Space Station. npj Microgravity 5, Article number: 1, doi.org/10.1038/s41526-018-0061-0 OSD-208, OSD-210
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Data Platform Beheshti, A., Shirazi-Fard, Y., Choi, S., Berrios, D., Gebre, S. G., Galazaka, J. M., Costes, S.V., (2019). Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Data Platform. J. Vis. Exp.(143) e58447, doi: 10.3791/58447
GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species Beheshti, A., McDonald, J. T., Miller, J., Grabham, P., Costes, S. C., (2019). GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species.Int. J. Mol. Sci,. 20(3), 661; doi.org/10.3390/ijms20030661 OSD-52, OSD-109, OSD-117
GeneLab: Omics database for spaceflight experiments Ray, S., Gebre, S., Fogle, H., Berrios, D. C., Tran, P. B., Galazka, J. G., Costes, S. V., (2019). GeneLab: Omics database for spaceflight experiments. Bioinformatics, 35(10), 1753–1759, doi:10.1093/bioinformatics/bty884
Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae Overbey, E. G., Paul, A. M., da Silveira, W. A., Tahamic, C. G. T., Reinsch, S. S., Szewczyk, N., Stanbouly, S., Wang, C., Galazka, J. M., Mao, X. W. (2019). Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae. Int. J. Mol. Sci., 20(17), 4094; doi.org:10.3390/ijms20174094 OSD-202
Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver Beheshti, A., Chakravarty, K., Fogle, H., Fazelinia, H., da Silveira, W. A., Boyko, V., Polo, S. J. L., Saravia-Butler, A., Hardiman, G., Taylor, D., Galazka, J. M., Costes, S. V. (2019) Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver, Sci Rep 9, 19195 (2019) doi.org/10.1038/s41598-019-55869-2 OSD-168, OSD-47, OSD-25, OSD-137
Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight Jiang, P., Green, S. J., Chlipala, G. E., Turek, F. W., Vitaterna, M. H. (2019). Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight. Microbiome 2019, 7:113, doi.org/10.1186/s40168-019-0724-4 OSD-48, OSD-168
A microRNA signature and TGF- 1 response were identified as the key master regulators for spaceflight awareness Beheshti A., Ray S., Fogle H., Berrios D., Costes S.V. (2018). A microRNA signature and TGF- 1response were identified as the key master regulators for spaceflight awareness. PLoS ONE 13(7): e0199621, doi.org/10.1371/journal.pone.0199621 OSD-25, OSD-21, OSD-63, OSD-111, OSD-4, OSD-61, OSD-48
FAIRness and Usability for Open-access Omics Data Systems Berrios, D.C., Beheshti, A., Costes, S. V., (2018) FAIRness and Usability for Open-access Omics Data Systems, AMIA Annu Symp Proc. Dec 5;2018:232-241. eCollection 2018.
Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study Beheshti A., Cekanaviciute, E., Smith, D. J., Costes, S. V., (2018). Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study. Scientific Reports 8, Article number: 4191. OSD-21, OSD-111, OSD-25, OSD-63, OSD-324
Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial “spaceflight response” Morrison, M., Nicholson, W. L., (2018). Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial “spaceflight response.” Scientific Reports8, Article number: 14403 OSD-185, OSD-145, OSD-138, OSD-39, OSD-31, OSD-15, OSD-11
NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies Beheshti, A., Miller, J., Kidane, Y., Berrios, D., Gebre, S.G., Costes, S.V., (2018) NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies. rrj: 189(6), 553-559; doi.org/10.1667/RR15062.1
Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the international space station Rettig, T. A., Ward, C., Pecaut, M. J., Chapes, S. K. (2017). Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the international space station. Gravitational and Space Research: publication of the American Society for Gravitational and Space Research, 5(1), 2-23. OSD-48, OSD-47, OSD-141
Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space Barcenilla B B, Meyers A D, Castillo-Gonzalez C, Young P, Min J H, Song J, Phadke C, et al (2023). Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space, Nature Communications. doi.org/10.1038/s41467-023-41510-4 OSD-38, OSD-120, OSD-218, OSD-427
Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions Zhang Y, Du X, Zhao L, Sun Y, (2024). Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions, International Journal of Radiation Biology. doi.org/10.1080/09553002.2024.2327393

Original Publications – 104

Title Description Datasets
Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station Nastasi N, Bope A, Meyer M E, Horack J M, Dannemiller K C, (2024). Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station, Microbiome. https://doi.org/10.1186/s40168-024-01864-3 OSD-694
Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system Lidberg K A, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald J W, Bammler T K, et al, (2024). Modeling celluar responses to serum and vitamin D in microgravity using a human kidney microphysiological system, npj microgravity. https://doi.org/10.1038/s41526-024-00415-2 OSD-516
Cosmic kidney disease: An integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction Siew K, Nestler K A, Nelson C, D’Ambrosio V, Zhong C, Li Z, Grillo A, et al, (2024). Cosmic kidney disease: An integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction, Nature Communications. doi: 10.1038/s41467-024-49212-1 OSD-72, OSD-102, OSD-163, OSD-212, OSD-249, OSD-250, OSD-253, OSD-336, OSD-342, OSD-457, OSD-462, OSD-465, OSD-466, OSD-513, OSD-530, OSD-532, OSD-571, OSD-575, OSD-706, OSD-707, OSD-708, OSD-709, OSD-710, OSD-712
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses Grigorev K, Nelson T M, Overbey E G, Hourebi N, Kim J, Najjar D, Damle N, et al (2024). Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses, Nature Communications. doi: 10.1038/s41467-024-48929-3 OSD-569
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight Tierney B T, Kim J, Overbey E G, Ryon K A, Foox J, Sierra M A, Bhattacharya C, et al (2024). Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight, Nature Microbiology. doi: 10.1038/s41564-024-01635-8 OSD-570, OSD-572, OSD-573, OSD-630
Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions Irby I and Broddrick J, (2024). Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions, Nature Communications. doi: 10.1038/s41467-023-42104-w OSD-582
Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew Jones C W, Overbey E G, Lacombe J, Ecker A J, Meydan C, Ryon K, Tierney, B, et al (2024). Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew, Nature. doi: 10.1038/s41586-024-07648-x OSD-569, OSD-570, OSD-571, OSD-572, OSD-573, OSD-574, OSD-575, OSD-630, OSD-656, OSD-687
Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response Husna N, Aiba T, Fujita S, Saito Y, Shiba D, Kudo T, Takahashi S, et al (2024). Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response, Nature Communications. doi: 10.1038/s41467-023-41995-z OSD-530, OSD-532
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight Houerbi N, Kim J, Overbey E G, Batra R, Schweickart A, Patras L, Lucotti S, et al (2024). Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight, Nature Communications. doi: 10.1038/s41467-024-48841-w OSD-530, OSD-569, OSD-571
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight Kim J, Tierney B T, Overbey E G, Dantas E, Fuentealba M, Park J, Narayanan S A, et al (2024). Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight, Nature Communications. doi: 10.1038/s41467-024-49211-2 OSD-530, OSD-570, OSD-575
Space radiation damage rescued by inhibition of key spaceflight-associated miRNAs McDonald J T, Kim J, Farmerie L, Johnson M L, Trovao N S, Arif S, Siew K, et al (2024). Space radiation damage rescued by inhibition of key spaceflight-associated miRNAs, Nature Communications. doi: 10.1038/s41467-024-48920-y OSD-334, OSD-335, OSD-336, OSD-337, OSD-530, OSD-570, OSD-577
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight Park J, Overbey E G, Narayanan S A, Kim J, Tierney B T, Damle N, Najjar D, et al (2024). Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight, Nature Communications. doi: 10.1038/s41467-024-48625-2 OSD-570, OSD-574
Spatiotemporal expression and control of haemoglobin in space Borg J, Loy C, Kim J, Buhagiar A, Chin C, Damle N, De Valminck I, et al (2024). Spatiotemporal expression and control of haemoglobin in space, Nature Communications. doi: 10.1038/s41467-024-49289-8 OSD-530, OSD-570
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing Al-Turki T M, Maranon D G, Nelson C B, Lewis A M, Luxton J J, Taylor L E, Altina N, et al (2024). Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing, Communications Biology. doi: 10.1038/s42003-024-06014-x OSD-569, OSD-570
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank Overbey E G, Kim J, Tierney B T, Park J, Houerbi N, Lucaci A G, Medina S G, et al (2024). The Space Omics and Medical Atlas (SOMA) and international astronaut biobank, Nature. doi: 10.1038/s41586-024-07639-y OSD-569, OSD-570, OSD-571, OSD-572, OSD-573, OSD-574, OSD-575, OSD-630, OSD-656
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids Chou J, Ramroop J R, Saravia-Butler A M, Wey B, Lera M P, Torres M L, Heavner M E, et al (2024). Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids, iScience. doi.org/10.1016/j.isci.2023.108759 OSD-588, OSD-609, OSD-610
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight Garcia-Medina J S, Sienkiewicz K, Narayanan S A, Overbey E G, Grigorev K, Ryon K A, Burke M, et al (2024). Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight, Precision Clinical Medicine. DOI: 10.1093/pcmedi/pbae007 OSD-570, OSD-572, OSD-573, OSD-630
Sexual dimorphism during integrative endocrine and immune responses to ionizing radiation in mice Burke M, Wong K, Talyansky Y, Mhatre S D, Mitchell C, Juran C M, Olson, et al (2024). Sexual dimorphism during integrative endocrine and immune responses to ionizing radiation in mice, Scientific Reports. doi: 10.1038/s41598-023-33629-7 OSD-566
Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight Zhou M, Riva A, Gauthier M P L, Kladde M P, Ferl R J, Paul A L, (2024). Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight, Biology Direct. doi.org/10.1186/s13062-024-00476-z OSD-625
Spaceflight effects on human vascular smooth muscle cell phenotype and function Scotti M M, Wilson B K, Bubenik J L, Yu F, Swanson M S, Allen J B, (2024). Spaceflight effects on human vascular smooth muscle cell phenotype and function, npj microgravity. doi.org/10.1038/s41526-024-00380-w OSD-635
Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces Flores P, McBride S A, Galazka J M, Varanasi K K, Zea L (2023). Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces, npj Microgravity. doi: 10.1038/s41526-023-00316-w OSD-554, OSD-627
Brachypodium distachyon Seedlings Display Accession-Specific Morphological and Transcriptomic Responses to the Microgravity Environment of the International Space Station Su S, Levine H, Masson P H, (2023). Brachypodium distachyon seedlings display accession-specific morphological and transcriptomic responses to the microgravity environment of the International Space Station, Life. https://doi.org/10.3390/life13030626 OSD-375
Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight Nakashima J, Pattathil S, Avci U, Chin S, Sparks J A, Hahn M G, Gilroy S, et al (2023). Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight, npj Microgravity. doi: 10.1038/s41526-023-00312-0 OSD-615
Simulated galactic cosmic ray exposure activates dose-dependent DNA repair response and down regulates glucosinolate pathways in arabidopsis seedlings Dixit A R, Meyers A D, Richardson B, Richards J T, Richards S E, Neelam S, Levine H G, et al (2023). Simulated galactic cosmic ray exposure activates dose-dependent DNA repair response and down regulates glucosinolate pathways in arabidopsis seedlings, Frontiers in Plant Science. doi: 10.3389/fpls.2023.1284529 OSD-658
Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight Bedree J K, Kerns K, Chen T, Lima B P, Liu G, Ha P, Shi J, et al (2023). Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight, Cell Reports. doi: 10.1016/j.celrep.2023.112299 OSD-417
Transcriptomic dynamics in the transition from ground to space are revealed by Virgin Galactic human-tended suborbital spaceflight Ferl R J, Zhou M, Strickland H F, Haveman N J, Callaham J B, Bandla S, Ambriz D, et al (2023). Transcriptomic dynamics in the transition from ground to space are revealed by Virgin Galactic human-tended suborbital spaceflight, npj Microgravity. doi.org/10.1038/s41526-023-00340-w OSD-624
Utilizing the KSC Fixation Tube to Conduct Human-Tended Plant Biology Experiments on a Suborbital Spaceflight Haveman N J, Zhou M, Callaham J, Strickland H F, Houze D, Manning-Roach S, Newsham G, et al, (2023). Utilizing the KSC Fixation Tube to conduct human-tended plant biology experiments on a suborbital spaceflight, Life. doi.org/10.3390/life12111871 OSD-565
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster Mhatre S D, Iyer J, Petereit J, Dolling-Boreham R M, Tyryshkina A, Paul A M, Gilbert R, et al (2022). Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster, Cell Reports. doi.org/10.1016/j.celrep.2022.111279 OSD-514
Development of an inexpensive 3D clinostat and comparison with other microgravity simulators using Mycobacterium marinum Clary J L, France C S, Lind K, Shi R, Alexander J S, Richards J T, Scott R S, et al, (2022). Development of an inexpensive 3D clinostat and comparison with other microgravity simulators using Mycobacterium marinum, Frontiers. doi.org/10.3389/frspt.2022.1032610
Draft Genome Sequences of Fungi Isolated from Mars 2020 Spacecraft Assembly Facilities Chander A M, Singh N K, Simpson A C, Seuylemezian A, Mason C E, Venkateswaran K (2022). Draft Genome Sequences of Fungi Isolated from Mars 2020 Spacecraft Assembly Facilities, Microbiology Resource Announcements. doi.org/10.1128/mra.00464-22 OSD-497, OSD-400
Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station Bijlani S, Parker C, Singh N K, Sierra M A, Foox J, Wang C C C, Mason C E, and Venkateswaran K, (2022). Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station, Journal of Fungi. doi.org/10.3390/jof8020165 OSD-290
Metabolic modeling of the International Space Station microbiome reveals key microbial interactions Kumar R K, Singh N K, Balakrishnan S, Parker C W, Raman K, Venkateswaran K, (2022). Metabolic modeling of the International Space Station microbiome reveals key microbial interactions, Microbiome. doi.org/10.1186/s40168-022-01279-y OSD-69
Microbial Tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station Urbaniak C, Morrison M D, Thissen J B, Karouia F, Smith D J, Mehta S, Jaing C, et al (2022). Microbial Tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station, Microbiome. doi.org/10.1186/s40168-022-01293-0 OSD-252
Mouse genomic associations with in vitro sensitivity to simulated space radiation Cekanaviciute E, Tran D, Nguyen H, Macha A L, Pariset E, Langley S, Babbi G, et al, (2022). Mouse genomic associations with in vitro sensitivity to simulated space radiation, Life Sciences in Space Research. doi.org/10.1016/j.lssr.2022.07.006 OSD-366
Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration Paul A L, Elardo S M, and Ferl R, (2022). Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration, Communications Biology. doi.org/10.1038/s42003-022-03334-8
Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation Laiakis E C, Pinheiro M, Nguyen T, Nguyen H, Beheshti A, Dutta S M, Russell W K, et al (2022). Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation, Frontiers in Physiology. doi.org/10.3389/fphys.2022.971282 OSD-505
Red Light Enhances Plant Adaptation to Spaceflight and Mars g-Levels Medina F J, Manzano A, Herranz R, and Kiss J Z (2022). Red Light Enhances Plant Adaptation to Spaceflight and Mars g-Levels, Life. doi.org/10.3390/life12101484 OSD-251, OSD-314, OSD-346
Spaceflight analogue culture enhances the host-pathogen interaction between Salmonella and a 3-D biomimetic intestinal co-culture model Barrila J, Yang J, Franco Meléndez KP, Yang S, Buss K, Davis TJ, Aronow BJ, et al, (2022). Spaceflight analogue culture enhances the host-pathogen interaction between Salmonella and a 3-D biomimetic intestinal co-culture model, Front Cell Infect Microbiology. doi.org/10.3389/fcimb.2022.705647 OSD-277
The Maleth program: Malta’s first space mission discoveries on the microbiome of diabetic foot ulcers Gatt C, Tierney B T, Madrigal P, Mason C E, Beheshti A, Telzerow A, Benes V, et al, (2022). The Maleth program: Malta’s first space mission discoveries on the microbiome of diabetic foot ulcers, Heliyon. doi.org/10.1016/j.heliyon.2022.e12075 OSD-487
An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity Rettig T A, Tan J C, Nishiyama N C, Chapes S K, Pecaut M J, (2021). An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity, ImmunoHorizons. doi: https://doi.org/10.4049/immunohorizons.2100056 OSD-141, OSD-164, OSD-201, OSD-214
Cell spinpods are a simple inexpensive suspension culture device to deliver fuid shear stress to renal proximal tubular cells Hammond T G, Nislow C, Christov I C, Batuman V, Nagrani P P, Barazandeh M, Upadhyay R, et al (2021). Cell spinpods are a simple inexpensive suspension culture device to deliver fuid shear stress to renal proximal tubular cells, Scientific Reports. doi.org/10.1038/s41598-021-00304-8
Diagnosing an Opportunistic Fungal Pathogen on Spaceflight-Grown Plants Using the MinION Sequencing Platform Haveman N J, Schuerger A C, (2021). Diagnosing an Opportunistic Fungal Pathogen on Spaceflight-Grown Plants Using the MinION Sequencing Platform, Astrobiology. doi: 10.1089/ast.2021.00491
Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule Blachowicz, A., Singh, N. K., Wood, J. M., Debieu, M., O’Hara, N. B., Mason, C. E., Venkateswarana, K., (2021). Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule, Microbiology Resource Announcements. doi.org/ 10.1128/MRA.01398-20 OSD-350
Draft genome sequences of heat shock-tolerant microbes isolated from a spacecraft assembly facility. Wood J M, Peres J B, Bateh J, Singh N K, Aronson H S, Hendrickson R, Mason C E, et al (2021). Draft genome sequences of heat shock-tolerant microbes isolated from a spacecraft assembly facility, Microbiology Resource Announcements. doi.org/10.1128/MRA.00653-21
Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station Simpson A C, Urbaniak C, Singh N K, Wood J M, Debieu M, O’Hara N B, Mason C E, (2021). Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station, Microbiology Resource Announcements. DOI: 10.1128/MRA.00214-21 OSD-361
Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome Laiakis, E. C., Shuryak, I., Deziel, A., Wang, Y., Barnette, B. L., Yu, Y., Ullrich, R. L., et al., (2021). Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome, International Journal of Molecular Sciences. doi.org/10.3390/ijms22063070
Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium Barrila, J., Sarker, S. F., Hansmeier, N., Yang, S., Buss, K., Briones, N., Park, J., Davis, R. R., Forsyth, R. J., Ott, C. M., Sato, K., Kosnik, C., Yang, A., Shimoda, C., Rayl, N., Ly, D., Landenberger, A., Wilson, S. D., Yamazaki, N., Steel, J., Montano, C., Halden, R.U., Cannon, T., Castro-Wallace, S. L. and Nickerson, C. A., (2021). Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium, Microgravity. doi.org/10.1038/s41526-021-00136-w OSD-323
Evaluating the lettuce metatranscriptome with MinION sequencing for future spaceflight food production applications Haveman N J, Khodadad C L M, Dixit A R, Louyakis A S, Massa G D, Venkateswaran K, and Foster J S, (2021). Evaluating the lettuce metatranscriptome with MinION sequencing for future spaceflight food production applications, npj Microgravity. doi.org/10.1038/s41526-021-00151-x
Long-read sequencing reveals increased occurrence of genomic variants and adenosine methylation in Bacillus pumilus SAFR-032 after long-duration flight exposure onboard the International Space Station Waters S M, Ledford S M, Wacker A, Verma S, Serda B, McKaig J, Varelas J, et al, (2021). Long-read sequencing reveals increased occurrence of genomic variants and adenosine methylation in Bacillus pumilus SAFR-032 after long-duration flight exposure onboard the International Space Station, International Journal of Astrobiology. doi.org/10.1017/S1473550421000343
Methylobacterium ajmalii sp. nov., Isolated From the International Space Station Bijlani, S., Singh, N. K., Eedara, V. V. R., Podile, A. R., Mason, C. E., Wang, C. C. C., and Venkateswaran, K., (2021). Methylobacterium ajmalii sp. nov., Isolated From the International Space Station, Frontiers in Microbiology. doi.org/10.3389/fmicb.2021.639396 OSD-300
Persistence of Escherichia coli in the microbiomes of red Romaine lettuce (Lactuca sativa cv. ‘Outredgeous’) and mizuna mustard (Brassica rapa var. japonica) – does seed sanitization matter? Dixit A R, Khodadad C L M, Hummerick M E, Spern C J, Spencer L E, Fischer J A, Curry A B, et al (2021). Persistence of Escherichia coli in the microbiomes of red Romaine lettuce (Lactuca sativa cv. ‘Outredgeous’) and mizuna mustard (Brassica rapa var. japonica) – does seed sanitization matter?, BMC Microbiology. doi.org/10.1186/s12866-021-02345-5
Spaceflight studies identify a gene encoding an intermediate filament involved in tropism pathways Shymanovicha T, Vandenbrink J P, Herranz R, Medina F J, Kiss J Z, (2021). Spaceflight studies identify a gene encoding an intermediate filament involved in tropism pathways, Plant Physiology and Biochemistry. doi.org/10.1016/j.plaphy.2021.12.039 OSD-251
Spatial Characterization of Microbial Communities on Multi-Species Leafy Greens Grown Simultaneously in the Vegetable Production Systems on the International Space Station Hummerick M E, Khodadad C L M, Dixit A R, Spencer L E, Maldonado-Vasquez G J, Gooden J L, Spern C J, et al (2021). Spatial Characterization of Microbial Communities on Multi-Species Leafy Greens Grown Simultaneously in the Vegetable Production Systems on the International Space Station, Life. doi.org/10.3390/life11101060
The Impact of Hindlimb Suspension on the Rat Eye: A Molecular and Histological Analysis of the Retina Theriot C A, Chevez-Barrios P, Loughlin T, Beheshti A, Mercaldo N D, Zanello S B, (2021). The Impact of Hindlimb Suspension on the Rat Eye: A Molecular and Histological Analysis of the Retina, Gravitational and Space Research. doi.org/10.2478/gsr-2021-0007
Approaches for Surveying Cosmic Radiation Damage in Large Populations of Arabidopsis thaliana Seeds – Antarctic Balloons and Particle Beams Califar, B., Tucker, R., Cromie, J., Sng, N., Schmitz, R. A., Callaham, J. A., Barbazuk, B., Paul, A-L, Ferl, R. J. (2020). Approaches for Surveying Cosmic Radiation Damage in Large Populations of Arabidopsis thaliana Seeds – Antarctic Balloons and Particle Beams, Gravitational and Space Research 6:2, doi.org/10.2478/gsr-2018-0010 OSD-210, OSD-210
Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice Paul, A, M., Cheng-Campbell, M., Blaber, E. A., Anand. S., Bhattacharya, S., Zwart, S. R., Crucian, B. E., et al., (2020). Beyond Low Earth Orbit: Characterizing the Immune Profile Following Simulated Spaceflight Conditions for Deep Space Missions, iScience. doi.org/10.1016/j.isci.2020.101747 OSD-336
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development Malkani, S., Chin, C. R., Cekanaviciute. E., Mortreux, M., Okinula, H., Tarbier, M., Schreurs, A. S., et al., (2020). Circulating miRNA Signature Predicts and Rescues Health Risks Associated with Spaceflight, Cell Reports. doi.org/10.1016/j.celrep.2020.108448 OSD-334, OSD-335, OSD-336, OSD-337
Competitive Growth Assay of Mutagenized Chlamydomonas reinhardtii Compatible With the International Space Station Veggie Plant Growth Chamber Zhang, J., Müller, B., Tyre, K. N., Hersh, H. L., Bai, F., Hu, Y., Resende, M., Jr, Rathinasabapathi, B., Settles, A. M. (2020). Competitive Growth Assay of Mutagenized Chlamydomonas reinhardtii Compatible With the International Space Station Veggie Plant Growth Chamber. Frontiers in plant science, 11, 631. doi.org/10.3389/fpls.2020.00631 OSD-265
Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station Bharadwaj, A.R., Daudu. R., Singh, N.K., Wood, J.M., Debieu, M., O’Hara, N.B., Karouia, F., Mason, C.E., Venkateswaran, K. (2020) Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station. Microbiology Resource Announcement – 9:e00817-20. doi.org/10.1128/MRA.00817-20. OSD-302, OSD-311
Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station Bijlani, S., Singh, N.K., Mason, C.E., Wang, C.C.C., Venkateswaran, K., (2020). Draft genome sequences of Sphingomonas species associated with the International Space Station. Microbiology Resource Announcement, 9:e00578-20. doi.org/10.1128/MRA.00578-20. OSD-298
Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station Bijlani, S., Singh, N. K., Mason, C. E., Wang, C. C. C., Venkateswaran, K. (2020). Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station. Microbiology Resource Announcements, 9, 26, e00504-20. OSD-290
LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition Wuu, Y., Hu, B., Okunola, H., Paul, A. M., Blaber, E. A., Cheng-Campbell, M., Beheshti, A., et al., (2020). LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition, iScience. doi.org/10.1016/j.isci.2020.101771 OSD-334, OSD-336
Microbiological and nutritional analysis of lettuce crops grown on the International Space Station Khodadad, C. L., Hummerick, M. E., Spencer, L. E., Dixit, A. R., Richards, J. T., Romeyn, M. W., Smith, T. M., Wheeler, R. M., Massa, G. D. (2020) Microbiological and Nutritional Analysis of Lettuce Crops Grown on the International Space Station. Front Plant Sci. 2020 Mar 6;11:199. doi: 10.3389/fpls.2020.00199. OSD-267, OSD-268, GLDS:269
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila Walls, S., Diop, S., Birse, R., Elmen, L., Gan, Z., Kalvakuri, S., Pineda, S., et al., (2020). Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila, Cell Reports. doi.org/10.1016/j.celrep.2020.108445 OSD-347
Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana Califar, B., Sng, N.J., Zupanska, A., Paul, A-L, Ferl, R.J. (2020). Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana. Frontiers in Plant Science 2020, 11:239, doi.org/10.3389/fpls.2020.00239 OSD-218
Sierra Nevada Sweep: Metagenomic Measurements of Bioaerosols Vertically Distributed Across the Troposphere Jaing, C., Thissen, J., Morrison, M. et al. (2020) Sierra Nevada Sweep: Metagenomic Measurements of Bioaerosols Vertically Distributed Across the Troposphere. Sci Rep 10, 12399. doi.org/10.1038/s41598-020-69188-4 OSD-256
Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses Kruse, C, P. S., Meyers, A. D., Basu, P., Hutchinson, S., Luisee, D. R., Wyatt, S. E., (2020). Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses. BCM Plant Biology, 2020; 20:237. doi.org/10.1186/s12870-020-02392-6 OSD-38
The Importance of Earth Reference Controls in Spaceflight -Omics Research: Characterization of Nucleolin Mutants from the Seedling Growth Experiments Manzano, A., Villacampa, A., Saez-Vasquez, J., Kiss, J. Z., Medina, F. J., and Herranz, R., (2020). The Importance of Earth Reference Controls in Spaceflight -Omics Research: Characterization of Nucleolin Mutants from the Seedling Growth Experiments, iScience. doi.org/10.1016/j.isci.2020.101686 OSD-313
The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation Urbaniak, C., Lorenzi, H., Thissen, J. et al. The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation. Microbiome 8, 56 (2020). doi.org/10.1186/s40168-020-00830-z OSD-280
Articular cartilage and sternal fibrocartilage respond differently to extended microgravity Fitzgerald, J., Endicott, J., Hansen, U., & Janowitz, C. (2019). Articular cartilage and sternal fibrocartilage respond differently to extended microgravity. NPJ Microgravity, 5, 3. doi:10.1038/s41526-019-0063-6 OSD-232
Cell cycle acceleration and changes in essential nuclear functions induced by simulated microgravity in a synchronized Arabidopsis cell culture Kamal, K. Y., Herranz, R., van Loon, J., & Medina, F. J. (2019). Cell cycle acceleration and changes in essential nuclear functions induced by simulated microgravity in a synchronized Arabidopsis cell culture. Plant Cell Environ, 42(2), 480-494. doi:10.1111/pce. OSD-144
Differential transcriptional profile through cell cycle progression in Arabidopsis cultures under simulated microgravity Kamal, K. Y., Herranz, R., van Loon, J., Medina, F. J., Herranz (2019). Differential transcriptional profile through cell cycle progression in Arabidopsis cultures under simulated gravity. ScienceDirect, doi.org/10.1016/j.ygeno.2019.01.007 OSD-144
Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice Rettig, T.A., Nishiyama, N.C., Pecaut, M.J., Chapes, S.K., (2019). Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Life Sciences in space Research 22:16, doi.org/10.1016/j.lssr.2019.06.001 OSD-214, OSD-201
Epigenomics in an extraterrestrial environment: organ-specific alteration of DNA methylation and gene expression elicited by spaceflight in Arabidopsis thaliana Zhou, M., Sng, N. J., LeFrois, C. E., Paul, A-L, Ferl, R. J., (2019). Epigenomics in an extraterrestrial environment: organ-specific alteration of DNA methylation and gene expression elicited by spaceflight in Arabidopsis thaliana. BMC Genomics 20:205, doi:10.1186/s12864-019-5554-z OSD-217
Establishing Standard Protocols for Bacterial Culture in Biological Research in Canisters (BRIC) Hardware Morrison, M.D., Fajardo-Cavazos, P., Nicholson, W., (2019). Comparison of Bacillus subtilis transcriptome profiles from two separate missions to the International Space Station. npj Microgravity 5, Article number:1 OSD-185, OSD-145, OSD-138
HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight Zupanska, A. K., LeFrois, C., Ferl, R. J., Paul, A-L. (2019). HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight. Int J Mol Sci, Jan 17;20(2). pii: E390. doi: 10.3390/ijms20020390. OSD-205
RNA seq analyses of Arabidopsis thaliana seedlings after exposure to blue light phototropic stimuli in microgravity Herranz, R., Vandenbrink, J.P., Villacampa, A., Manzano, A., Poehlman, W., Feltus, F. A., Kiss, J. Z., Medina, M. J. (2019), RNA seq analyses of Arabidopsis thaliana seedlings after exposure to blue light phototropic stimuli in microgravity, doi.org/10.1002/abj2.1384 OSD-251
Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana Beisel, N.S., Noble, J., Barbazuk, B. W., Paul, A-L., Ferl, R. J., (2019). Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana. npj Microgravity 5:9, doi:10.1038/s41526-019-0070-7 OSD-218
Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight Choi, W. G., Barker, R. J., Kim, S. H., Swanson, S. J., & Gilroy, S. (2019). Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight. Am J Bot, 106(1), 123-136. doi:10.1002/ajb2.1223 OSD-37
Airborne Bacteria in Earth’s Lower Stratosphere Resemble Taxa Detected in the Troposphere: Results from a New NASA Aircraft Bioaerosol Collector (ABC) Smith, D. J., Ravichandar, J. D., Jain, S., Griffin, D. W., Yu, H., Tan, Q., . . . McGrath, J. (2018). Airborne Bacteria in Earth’s Lower Stratosphere Resemble Taxa Detected in the Troposphere: Results From a New NASA Aircraft Bioaerosol Collector (ABC). Front Microbiol, 9, 1752. doi:10.3389/fmicb.2018.01752 OSD-170
Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing Rettig, T. A., Ward, C., Bye, B. A., Pecaut, M. J., & Chapes, S. K. (2018). Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. PLoS One, 13(1), e0190982. doi:10.1371/journal.pone.0190982 OSD-141
Comparing RNA Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight Krishnamurthy, A., Ferl, R. J., Paul, A-L., (2018). Comparing RNA Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight. Applications in Plant Sciences, 6(11): e01197, doi:10.1002/aps3.1197 OSD-208
Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces Urbaniak, C., Sielaff, A. C., Frey, K. G., Allen, J. E., Singh, N., Jaing, C., . . . Venkateswaran, K. (2018). Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces. Sci Rep, 8(1), 814. doi:10.1038/s41598-017-18506-4 OSD-66
Draft Genome Sequence of a Clinical Isolate of Fusarium fujikuroi Isolated from a Male Patient with Acute Myeloid Leukemia Urbaniak, C., Dadwal, S., Bagramyan, K., & Venkateswaran, K. (2018). Draft Genome Sequence of a Clinical Isolate of Fusarium fujikuroi Isolated from a Male Patient with Acute Myeloid Leukemia. Genome Announc, 6(25). doi:10.1128/genomeA.00476-18
Draft Genome Sequences of Two Fusarium oxysporum Isolates Cultured from Infected Zinnia hybrida Plants Grown on the International Space Station Urbaniak, C., Massa, G., Hummerick, M., Khodadad, C., Schuerger, A., & Venkateswaran, K. (2018). Draft Genome Sequences of Two Fusarium oxysporum Isolates Cultured from Infected Zinnia hybrida Plants Grown on the International Space Station. Genome Announc, 6(20). doi:10.1128/genomeA.00326-18 OSD-177
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice Ward, C., Rettig, T. A., Hlavacek, S., Bye, B. A., Pecaut, M. J., & Chapes, S. K. (2018). Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice. Life Sci Space Res (Amst), 16, 63-75. doi:10.1016/j.lssr.2017.11.003 OSD-164
Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains Singh, N. K., Bezdan, D., Checinska Sielaff, A., Wheeler, K., Mason, C. E., & Venkateswaran, K. (2018). Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains. BMC Microbiol, 18(1), 175. doi:10.1186/s12866-018-1325-2 OSD-67
Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces Singh, N. K., Wood, J. M., Karouia, F., & Venkateswaran, K. (2018). Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces. Microbiome, 6(1), 214. doi:10.1186/s40168-018-0609-y OSD-69
Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spaceflight Johnson, C. M., Subramanian, A., Pattathil, S., Correll, M. J., & Kiss, J. Z. (2017). Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spaceflight. Am J Bot, 104(8), 1219-1231. doi:10.3732/ajb.1700079 OSD-121
Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station Venkateswaran, K., Checinska Sielaff, A., Ratnayake, S., Pope, R. K., Blank, T. E., Stepanov, V. G., . . . Bergman, N. H. (2017). Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station. Genome Announc, 5(32). doi:10.1128/genomeA.00680-17 OSD-64
Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight? Paul, A. L., Sng, N. J., Zupanska, A. K., Krishnamurthy, A., Schultz, E. R., & Ferl, R. J. (2017). Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight? PLoS One, 12(6), e0180186. doi:10.1371/journal.pone.0180186 OSD-120
Growth in spaceflight hardware results in alterations to the transcriptome and proteome Basu, P., Kruse, C. P. S., Luesse, D. R., & Wyatt, S. E. (2017). Growth in spaceflight hardware results in alterations to the transcriptome and proteome. Life Sci Space Res (Amst), 15, 88-96. doi:10.1016/j.lssr.2017.09.001 OSD-38
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? Pecaut, M. J., Mao, X. W., Bellinger, D. L., Jonscher, K. R., Stodieck, L. S., Ferguson, V. L., . . . Gridley, D. S. (2017). Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? PLoS One, 12(5), e0174174. doi:10.1371/journal.pone.0174174 OSD-108, OSD-125
Nanopore DNA Sequencing and Genome Assembly on the International Space Station Castro-Wallace, S. L., Chiu, C. Y., John, K. K., Stahl, S. E., Rubins, K. H., McIntyre, A. B. R., . . . Burton, A. S. (2017). Nanopore DNA Sequencing and Genome Assembly on the International Space Station. Sci Rep, 7(1), 18022. doi:10.1038/s41598-017-18364-0 OSD-84
Non-Toxin-Producing Bacillus cereus Strains Belonging to the B. anthracis Clade Isolated from the International Space Station Venkateswaran, K., Singh, N. K., Checinska Sielaff, A., Pope, R. K., Bergman, N. H., van Tongeren, S. P., . . . Perry, J. (2017). Non-Toxin-Producing Bacillus cereus Strains Belonging to the B. anthracis Clade Isolated from the International Space Station. mSystems, 2(3). doi:10.1128/mSystems.00021-17 OSD-64
Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana Kruse, C. P. S., Basu, P., Luesse, D. R., & Wyatt, S. E. (2017). Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana. PLoS One, 12(4), e0175943. doi:10.1371/journal.pone.0175943 OSD-38
Whole metagenome profiles of particulates collected from the International Space Station. Be, N. A., Avila-Herrera, A., Allen, J. E., Singh, N., Sielaff, A. C., Jaing, C., & Venkateswaran, K. (2017). Whole meta genome profiles of particulates collected from the International Space Station. Microbiome, 5:81, doi.org/10.1186/s40168-017-0292-4 OSD-64
Draft Genome Sequences of Biosafety Level 2 Opportunistic Pathogens Isolated from the Environmental Surfaces of the International Space Station Checinska Sielaff, A., Singh, N. K., Allen, J. E., Thissen, J., Jaing, C., & Venkateswaran, K. (2016). Draft Genome Sequences of Biosafety Level 2 Opportunistic Pathogens Isolated from the Environmental Surfaces of the International Space Station. Genome Announc, 4(6). doi:10.1128/genomeA.01263-16 OSD-67
Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress Abshire, C., Prasai, K., Soto, I., Shi, R., Concha, M., Baddoo, M., Flemington, E. K., Ennis, D. G., Scott, R. S., Harrison, L. (2016). Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress. npc Microgravity 2, 16038 (2016). doi.org/10.1038/npjmgrav.2016.38 OSD-90
Spaceflight Activates Lipotoxic Pathways in Mouse Liver Jonscher, K. R., Alfonso-Garcia, A., Suhalim, J. L., Orlicky, D. J., Potma, E. O., Ferguson, V. L., . . . Pecaut, M. J. (2016). Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver.PLoS One, 11(5), e0155282. doi:10.1371/journal.pone.0155282 OSD-25
Molecular effects of spaceflight in the mouse eye after space shuttle mission STS-135 Theriot, C. A., Zanello, S. B., (2014). Molecular effects of spaceflight in the mouse eye after space shuttle mission STS-35. Gravitational and Space Research: publication of the American Society for Gravitational and Space Research, 2(1), 08-2014. OSD-87
Spaceflight Transcriptomes: Unique Responses to a Novel Environment Paul, A. L., Zupanska, A. K., Ostrow, D. T., Zhang, Y., Sun, Y., Li, J. L., Shanker, S., Farmerie, W. G., Amalfitano, C. E., Ferl, R. J. (2012). Spaceflight Transcriptomes: Unique Responses to a Novel Environment, Astrobiology. 2012 Jan;12(1):40-56. doi: 10.1089/ast.2011.0696.
Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain IF3SW-P1, Isolated from the International Space Station Sushenko N S, Singh N K, Vellone D L, Tighe S W, Hedlund B P, Venkateswaran K, Mose D P (2022). Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain IF3SW-P1, Isolated from the International Space Station, Microbiol Resour Annonc. doi: 10.1128/mra.00476-22. Epub 2022 Jun 23. OSD-470
Spaceflight influences gene expression, photoreceptor integrity and oxidative stress-related damage in the murine retina Overbey, E. G., da Silveira, W. A., Stanbouly, S., Nishiyama, N.C., Roque-Torres, G. D., Pecaut, M. J., Zawieja, D. C., Wang, C., Willey, J. S., Delp, M. D., Hardiman, G., Mao, X. W. OSD-255

OSDR Publications in the News – 62

Title Description Datasets
Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation Yan W, Hu W, Song Y, Liu X, Zhou Z, Li W, Cao Z, et al, (2024). Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation, Molecular Therapy Nucleic Acids. doi: 10.1016/j.omtn.2024.102260
Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening Kim S, Ayan B, Shayan M, Rando T A, Huang N F, (2024). Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening, Stem Cell Reports. doi: 10.1016/j.stemcr.2024.06.010
A second space age spanning omics, platforms, and medicine across orbits Mason C E, Green J, Adamopoulos K I, Afshin E E, Baechle J J, Basner M, Bailey S M, et al, (2024). A second space age spanning omics, platforms, and medicine across orbits, Nature. doi: 10.1038/s41586-024-07586-8
Astronaut omics and the impact of space on the human body at scale Rutter L A, Cope H, MacKay M J, Herranz R, Das S, Ponomarev S A, Costes, S V, et al, (2024). Astronaut omics and the impact of space on the human body at scale, Nature Communications. doi: 10.1038/s41467-024-47237-0
Biological horizons: pioneering open science in the cosmos Costes S V, Gentemann C L, Platts S H, Carnell L A, (2024). Biological horizons: pioneering open science in the cosmos, Nature Communications. doi: 10.1038/s41467-024-48633-2
Understanding how space travel affects the female reproductive system Mathyk B, Imudia A N, Quaas A M, Halicigil C, Karouia F, Avci P, Nelson N G, et al, (2024). Understanding how space travel affects the female reproductive system, npj Women’s Health. doi: 10.1038/s44294-024-00009-z
Domains of life sciences in spacefaring: What, where, and how to get involved Berliner A J, Zezulka S, Hutchinson G A, Bertoldo S, Cockell C S, Arkin A P, (2024). Domains of life sciences in spacefaring: What, where, and how to get involved, npj Microgravity. DOI: 10.1038/s41526-024-00354-y
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? Willis C R G, Calvaruso M, Angeloni D, Baatout S, Benchoua A, Bereiter-Hahn J, Bottai D, et al, (2024). How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?, npj microgravity. doi.org/10.1038/s41526-024-00395-3
Long-term space missions’ effects on the human organism: What we do know and what requires further research Tomsia M, Cie la J, mieszek J, Florek S, Macionga A, Michalczyk K, Stygar D, (2024). Long-term space missions’ effects on the human organism: What we do know and what requires further research., Frontiers in Physiology. DOI 10.3389/fphys.2024.1284644
Metabolomic Profiling of the Secretome from Human Neural Stem Cells Flown into Space Biancotti J C, Espinosa-Jeffrey A, (2024). Metabolomic Profiling of the Secretome from Human Neural Stem Cells Flown into Space, bioengineering. doi.org/10.3390/bioengineering11010011
Mitochondrial stress in the spaceflight environment Rudolf A M and Hood W R, (2024). Mitochondrial stress in the spaceflight environment, Mitochondrion. doi.org/10.1016/j.mito.2024.101855
Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight Blottner D, Moriggi M, Trautmann G, Furlan S, Block K, Gutsmann M, Torretta E, et al, (2024). Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight, antioxidants. doi.org/10.3390/antiox13040432
Omics Studies of Tumor Cells under Microgravity Conditions Graf J, Herbert S, Wehland M, Corydon T J, Sahana J, Abdelfattah F, Wuest S L, et al, (2024). Omics Studies of Tumor Cells under Microgravity Conditions, International Journal of Molecular Sciences. doi.org/10.3390/ijms25020926
Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data Kotlov N, Shaposhnikov K, Tazearslan C, Chasse M, Baisangurov A, Podsvirova S, Fernandez D, et al, (2024). Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data, communications biology. doi.org/10.1038/s42003-024-06020-z
Roadmap for the next decade of plant programmed cell death research Kacprzyk J, Burke R, Armengot L, Coppola M, Tattrie S B, Vahldick H, Bassham D C, et al, (2024). Roadmap for the next decade of plant programmed cell death research, New Phytologist. doi.org/10.1111/nph.19709
Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues Ren Z, Ahn E H, Do M, Mair D B, Monemianesfahani A, Lee P H U, Kim D H, (2024). Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues, npj Microgravity. DOI: 10.1038/s41526-024-00353-z
The use of RNA-seq for the study of Physiological Adaptations of Halophiles in Extreme Environments for Astrobiological Data Interpretation Basu C and Perl S M, (2024). The use of RNA-seq for the study of Physiological Adaptations of Halophiles in Extreme Environments for Astrobiological Data Interpretation, Frontiers. DOI 10.3389/fspas.2024.1342694
Translating genetic findings to epigenetics: identifying the mechanisms associated with aging after high-radiation exposure on earth and in space Ruprecht N A, Singhal S, Sens D, Singhal S K, (2024). Translating genetic findings to epigenetics: identifying the mechanisms associated with aging after high-radiation exposure on earth and in space, Frontiers In Public Health. DOI 10.3389/fpubh.2024.1333222
Big Data for a Small World: A Review on Databases and Resources for Studying Microbiomes Sengupta P, Sivabalan S K M, Mahesh A, Palanikumar I, Baskaran D K K, and Raman K (2023). Big Data for a Small World: A Review on Databases and Resources for Studying Microbiomes, Journal of the Indian Institute of Science.
Biological research and self-driving labs in deep space supported by artificial intelligence Sanders L M , Scott R T , Yang J H , Qutub A A, Martin H G, Berrios D C, Hastings J J A , et al, (2023). Biological research and self-driving labs in deep space supported by artificial intelligence, nature machine intelligence. doi.org/10.1038/s42256-023-00618-4
Biomonitoring and precision health in deep space supported by artificial intelligence Scott R T, Sanders L M, Antonsen E L, Hastings J J A, Park S M, Mackintosh G, Reynolds R J, et al, (2023). Biomonitoring and precision health in deep space supported by artificial intelligence, nature machine intelligence. doi.org/10.1038/s42256-023-00617-5
Current Knowledge about the Impact of Microgravity on Gene Regulation Corydon T J, Schulz H, Richter P, Strauch S M, Böhmer M, Ricciardi D A, Wehland M, et al (2023). Current Knowledge about the Impact of Microgravity on Gene Regulation, Cells doi.org/10.3390/cells12071043
Database of space life investigations and information on spacefight plant biology Wang S, Wang J, Zeng X, Wang T, Yu Z, Wei Y, Cai M, et al (2023). Database of space life investigations and information on spacefight plant biology, Planta. DOI: 10.1007/s00425-023-04213-0
Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research Manzano A, Weging S, Bezdan D, Borg J, Cahill T, Carnero-Diaz E, Cope H, et al (2023). Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research, iScience. DOI: 10.1016/j.isci.2023.107289
Exploratory Tool for Radiation Exposure from Spaceflight: Rad-Bio-App Ghosh D, Verma E, Ghosh R K, and Anderson T, (2023). Exploratory Tool for Radiation Exposure from Spaceflight: Rad-Bio-App, International Journal of Medical Science and clinical Invention. DOI:10.18535/ijmsci/v10i1.03
Exploring outer space biophysical phenomena via SpaceLID Wang S, Wang T, Zeng X, Chu X, Zhuoma D, Zhao Y, and Chen Y Z, (2023). Exploring outer space biophysical phenomena via SpaceLID, Scientific Reports. DOI: 10.1038/s41598-023-44729-9
Lab Medicine in Space Wiencek J R, Das S, Beheshti A, Crucian B E, Karouia F, Trudel G, and McMonigalm K A, (2023). Lab Medicine in Space, Clinical Chemistry. doi.org/10.1093/clinchem/hvad035
Metagenomic Methods for Addressing NASA’s Planetary Protection Policy Requirements on Future Missions: A Workshop Report Green S J, Torok T, Allen J E, Eloe-Fadrosh E, Jackson S A, Jiang S C, Levine S S, et al (2023). Metagenomic Methods for Addressing NASA’s Planetary Protection Policy Requirements on Future Missions: A Workshop Report, Astrobiology. DOI: 10.1089/ast.2022.0044
Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles Richardson R B, and Mailloux R J, (2023). Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles, Antioxidants. doi.org/10.3390/antiox12030674
Photosynthetic microorganisms, an overview of their biostimulant effects on plants and perspectives for space agriculture Renaud C, Leys N, and Wattiez R (2023). Photosynthetic microorganisms, an overview of their biostimulant effects on plants and perspectives for space agriculture, Journal of Plant Interactions. DOI: 10.1080/17429145.2023.2242697
Plant Reactome Knowledgebase: empowering plant pathway exploration and OMICS data analysis Gupta P, Elser J, Hooks E, D’Eustachio P, Jaiswal P, and Naithani S, (2023). Plant Reactome Knowledgebase: empowering plant pathway exploration and OMICS data analysis, Nucleic Acids Research. DOI: 10.1093/nar/gkad1052
RNA-Seq Alignment and Differential Expression Software Comparison Munster S K, Nicholson S J, Uyhelji H A (2023). RNA-Seq Alignment and Differential Expression Software Comparison, Civil Aerospace Medical Institute (CAMI) Federal Aviation Administration. doi.org/10.21949/1524443
Spaceflight Induces Strength Decline in Caenorhabditis elegans Soni P, Edwards H, Anupom T, Rahman M, Lesanpezeshki L, Blawzdziewicz J, Cope H, et al (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans, Cells. DOI: 10.3390/cells12202470
A Sankofian appraisal on how to maximize translatability of rodent space radiation/CNS studies to astronauts Brittena R A, Sanford L D, Guo M L, Krishnan B, Emmett M R, Laiakis E C, (2022). A Sankofian appraisal on how to maximize translatability of rodent space radiation/CNS studies to astronauts,” The Health Risks of Extraterrestrial Environments (THREE).
Alternative splicing diversifes the skeletal muscle transcriptome during prolonged spacefight Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, AdamsJ S, et al, (2022). Alternative splicing diversifes the skeletal muscle transcriptome during prolonged spacefight, Skeletal Muscle. doi.org/10.1186/s13395-022-00294-9
Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, Adams J S, et al (2022). Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight, Skeletal Muscle. doi.org/10.1186/s13395-022-00294-9
Benchmark dose modeling of transcriptional data: a systematic approach to identify best practices for study designs used in radiation research Stainforth R, Vuong N, Adam N, Kuo B, Wilkins R C, Yauk C, Beheshti B, et al, (2022). Benchmark dose modeling of transcriptional data: a systematic approach to identify best practices for study designs used in radiation research, International Journal of Radiation Biology. doi.org/10.1080/09553002.2022.2110300.
Building the Space Omics Topical Team to boost European space researchers’ role in the international consortia redefining spaceflight-generated datasets Herranz R, da Silveira W, Bezdan D, Giacomello S, and Szewczyk N (2022). Building the Space Omics Topical Team to boost European space researchers’ role in the international consortia redefining spaceflight-generated datasets, iScience. doi: 10.1016/j.isci.2022.10486
Clinical trial in a dish for space radiation countermeasure discovery. Cao X, Weil M M, Wu J C, (2022). Clinical trial in a dish for space radiation countermeasure discovery, Life Sci Space Res. doi.org/10.1016/j.lssr.2022.05.006
Data Processing as Sharing Practice: Making Space Plant Biology at NASA GeneLab Castano P, (2022). Data Processing as Sharing Practice: Making Space Plant Biology at NASA GeneLab, The 9th biennial conference of the Society for Philosophy of Science in Practice, pg 64-65.
Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines? Lau P, Vico L, and Rittweger J, (2022). Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?, Biomedicines. doi.org/10.3390/biomedicines10020342
Estrogen receptor regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity Jiang M, Liu Z, Shao J, Zhou J, Wang H, Song C, Li X, et al, (2022). Estrogen receptor regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity, Frontiers. doi: 10.3389/fphys.2022.1039913
From Cultured Vascular Cells to Vessels: The Cellular and Molecular Basis of Vascular Dysfunction in Space Locatelli L, Castiglioni S, Maier J A M, (2022). From Cultured Vascular Cells to Vessels: The Cellular and Molecular Basis of Vascular Dysfunction in Space, Front Bioeng Biotechnol. doi: 10.3389/fbioe.2022.862059
Integrating bioinformatic strategies in spatial life science research Hao Y, Lu L, Liu A, Lin X, Xiao L, Kong X, Li K, et al (2022). Integrating bioinformatic strategies in spatial life science research, Briefings in Bioinformatics. doi.org/10.1093/bib/bbac415
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments DiCarlo A L, Carnell L S, Rios C I, Prasanna P G, (2022). Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments, Life Sciences in Space Research. doi.org/10.1016/j.lssr.2022.06.004
Latest knowledge about changes in the proteome in microgravity Schulz H, Strauch S M, Richter P, Wehland M, Krüger M, Sahana J, Corydon T J, et al, (2022). Latest knowledge about changes in the proteome in microgravity, Expert Review of Proteomics. doi.org/10.1080/14789450.2022.2030711
Meta-analysis of health research data from greater than three months International Space Station missions Kunitskaya A, PiretJ M, Buckley N, Low-Décarie E (2022). Meta-analysis of health research data from greater than three months International Space Station missions, Acta Astronautica. doi.org/10.1016/j.actaastro.2022.09.019
Multiscale modeling in the framework of biological systems and its potential for spaceflight biology studies Millar-Wilson A, Ward Ó, Duffy E, Hardiman G, (2022). Multiscale modeling in the framework of biological systems and its potential for spaceflight biology studies, iScience. doi: 10.1016/j.isci.2022.105421
Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature. Russo C D, Bandiera T, Monici M, Surdo L, Yip V L M, Wotring V, Morbidelli L, (2022). Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature, British Journal of Pharmacology. DOI: 10.22541/au.162636523.37754419/v1
Plants in Microgravity: Molecular and Technological Perspectives Baba A I, Mir M Y, Riyazuddin R, Cséplo A, Rigó G, and Fehér A (2022). Plants in Microgravity: Molecular and Technological Perspectives, International Journal of Molecular Sciences. doi.org/10.3390/ijms2318105487
Rare diseases and space health: Optimizing synergies from scientific questions to care Puscas M, Martineau G, Bhella G, Bonnen P E, Carr P, Lim R, Mitchell J, et al, (2022). Rare diseases and space health: Optimizing synergies from scientific questions to cares, NPJ Microgravity. doi: 10.1038/s41526-022-00224-5
Routine omics collection is a golden opportunity for European human research in space and analog environments Cope H, Willis C R G, MacKay M J, Rutter L A, Toh L S, Williams P M, Herranz R, et al, (2022). Routine omics collection is a golden opportunity for European human research in space and analog environments, Patterns. doi.org/10.1016/j.patter.2022.100550
The Biological Problems of Space Travel Reid M, (2022). The Biological Problems of Space Travel, Ideas Magazine.
The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model Grimm D, Schulz H, Krüger M, Cortés-Sánchez J L, Egli M, Kraus A, Sahana J, et al, (2022). The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model, International Journal of Molecular Sciences. doi.org/10.3390/ijms23063073.
The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity Ji G, Chang H, Yang M, Chen H, Wang T, Liu X, Lv K, et al, (2022). The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity, PLOS ONE. doi.org/10.1371/journal. pone.0265108.
Validating Causal Diagrams of Human Health Risks for Spaceflight: An Example Using Bone Data from Rodents Reynolds R J, Scott R T, Turner R T, Iwaniec U T, Bouxsein M L, Sanders L M, and Antonsen E L, (2022). Validating Causal Diagrams of Human Health Risks for Spaceflight: An Example Using Bone Data from Rodents, Biomedicines. doi.org/10.3390/biomedicines10092187
A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression Michalettou T D, Michalopoulos I, Costes S V, Hellweg C E, Hada M, and Georgakilas A G, (2021). A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression, Life. doi.org/10.3390/ life11020115
Animal Models for Radiotherapy Research: All (Animal) Models Are Wrong but Some Are Useful Butterworth K T, and Williams J P, (2021). Animal Models for Radiotherapy Research: All (Animal) Models Are Wrong but Some Are Useful, Cancers. doi.org/10.3390/cancers 13061319
Animal models, open science, & space-omics Neff E P, (2021). Animal models, open science, & space-omics, Lab Animal. doi.org/10.1038/s41684-021-00776-1
Cyanobacteria and microalgae in supporting human habitation on Mars Mapstone L J, Leite M N, Purton S, Crawford I A, Dartnell L, (2021). Cyanobacteria and microalgae in supporting human habitation on Mars, Biotechnology Advances. doi.org/10.1016/j.biotechadv.2022.107946 OSD-265
Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells Beheshti A, McDonald J T, Hada M, Takahashi A, Mason C E, and Mognato M, (2021). Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells, International Journal of Molecular Sciences. doi.org/10.3390/ijms221910507
Conducting Plant Experiments in Space and on the Moon Shymanovich T and Kiss J Z, (2022). Conducting Plant Experiments in Space and on the Moon, Plant Gravitropism Methods in Molecular Biology. doi: 10.1007/978-1-0716-1677-2_12

Student Publications – 10

Title Description Datasets
Select Pathways Revealed in A. Thaliana During Spaceflight Via Meta-Analysis of National Aeronautics and Space Administration Genelab Data Baham, Z T, (2023). Select Pathways Revealed in A. Thaliana During Spaceflight Via Meta-Analysis of National Aeronautics and Space Administration Genelab Data. [Master’s Thesis, Louisiana Tech University]. OSD-7, OSD-38, OSD-120, OSD-205, OSD-213, OSD-251, OSD-314, OSD-469
Characterizing the relative biologic effectiveness following clinical and space-relevant ionizing radiation exposures and exploring curcumin nanoparticles as effective radiological countermeasures Evans A C, (2022). Characterizing the relative biologic effectiveness following clinical and space-relevant ionizing radiation exposures and exploring curcumin nanoparticles as effective radiological countermeasures. [Doctoral thesis, University of California Davis].
Computational techniques for simulation and design of a biological sample irradiation chamber Giunta E, (2022). Computational techniques for simulation and design of a biological sample irradiation chamber. [Master’s Thesis, Kansas State University].
Differential Gene Expression Analysis of Zebrafish Embryos Exposed to Simulated Microgravity and Insights into Cellular Effects Lien N, (2022). Differential Gene Expression Analysis of Zebrafish Embryos Exposed to Simulated Microgravity and Insights into Cellular Effects. [Master’s Projects, San Jose State University]. Master’s Thesis and Graduate Research. OSD-373, OSD-289
Effects of Aeration on Soybean Plant Growth in Lunar and Martian Regolith Josh Bailey, Kyra Keenan, Alessandro Paz, Riya Dharmendra Raj, Madelyn Whitaker, Brian Wodetzki, Autumn Wuebben, (2022). Effects of Aeration on Soybean Plant Growth in Lunar and Martian Regolith. [Purdue Interplanetary and Space Agriculture, Undergraduate Division].
The role of osteocytes in mechanical unloading and age-induced osteopenia Uda Y, (2022). The role of osteocytes in mechanical unloading and age-induced osteopenia. [Boston University]. Doctoral dissertation. OSD-50, OSD-107
An Examination of Bone Loss During Space Travel with Differential Gene Expression Analysis Vo C, (2021). An Examination of Bone Loss During Space Travel with Differential Gene Expression Analysis. [Master’s Projects, San Jose Sate University]. Master’s Theses and Graduate Research. DOI: https://doi.org/10.31979/etd.an9m-wtkd OSD-241
Effects Of Microgravity and Partial Gravity and the Influence of Photostimulation on Plant Adaptation to Spaceflight Calvo A V, (2021). Effects of Microgravity and Partial Gravity and the Influence of Photostimulation on Plant Adaptation to Spaceflight. [Doctoral thesis, Universidad Autónoma de Madrid]. CSIC – Centro de Investigaciones Biológicas Margarita Salas (CIB). http://hdl.handle.net/10261/253186 OSD-251, OSD-313, OSD-314
Spaceflight and Differential Gene Expression Analysis of Mice Quadriceps Exposed to Microgravity Nguyen T, (2021). Spaceflight and Differential Gene Expression Analysis of Mice Quadriceps Exposed to Microgravity. [Master’s Projects, San Jose Sate University]. Master’s Theses and Graduate Research. DOI: https://doi.org/10.31979/etd.4tt8-8a9h OSD-103
Spaceflight and the Differential Gene Expression of Human Stem Cell-Derived Cardiomyocytes Zhu E, (2021). Spaceflight and the Differential Gene Expression of Human Stem Cell-Derived Cardiomyocytes. [Master’s Projects, San Jose Sate University]. Master’s Theses and Graduate Research. DOI: https://doi.org/10.31979/etd.ub3z-s62y OSD-258

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