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ISS National Laboratory

Fostering scientific and technological innovation, advancing US leadership in commercial space, and inspiring the next generation.

The International Space Station photographed by Expedition 56 crew members from a Soyuz spacecraft after undocking. NASA astronauts Andrew Feustel and Ricky Arnold and Roscosmos cosmonaut Oleg Artemyev executed a fly around of the orbiting laboratory to take pictures of the station before returning home after spending 197 days in space. The station will celebrate the 20th anniversary of the launch of the first element Zarya in November 2018. Credit: NASA/Roscosmos

About ISS National Lab

In an effort to expand the research opportunities of this unparalleled platform, the ISS was designated as a U.S. National Laboratory in 2005 by Congress, enabling space research and development access to a broad range of commercial, academic, and government users. 

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Space-Grown Brain Organoids Help Advance New Neurological Treatment

Did you know some viruses don’t cause illness and can instead be used to treat disease? Biotechnology startup Axonis Therapeutics reprogrammed a virus to carry a novel gene therapy to neurons to treat neurological conditions like Alzheimer’s, Parkinson’s, and spinal cord injury. The company needed a way to test the therapeutic in a mature human brain model, which is difficult to produce on Earth. To address this challenge, Axonis leveraged the International Space Station National Laboratory to quickly grow 3D human brain organoids and test the therapeutic.

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An image captured during in-orbit microscopy showing a human brain organoid model of iSPC-derived neurons and astrocytes expressing a neuron-specific AAV vector-delivered gene.
Media Credit: Axonis Theraputics

Station Opportunity

Up to $1.6 Million in Funding Available for NSF Tissue Engineering Research

Solicitation now open for multiple awards supporting space-based tissue engineering and mechanobiology research

For the eighth consecutive year, the U.S. National Science Foundation (NSF) is funding a solicitation seeking projects that utilize the International Space Station National Laboratory to advance tissue engineering and mechanobiology research. Through this solicitation, NSF will provide up to $1.6 million in total funding for multiple projects.

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NASA astronaut Jasmin Moghbeli works with the BioFabrication Facility on the ISS Media Credit: NASA
NASA astronaut Jasmin Moghbeli works with the BioFabrication Facility on the ISS
Credits: NASA

Publication Highlights Groundbreaking Physical Science Research in Space

A paper published in Gravitational and Space Research unveils insights gained from International Space Station National Laboratory-sponsored research on transport phenomena, fundamental physical processes involving momentum, energy, and mass transfer. Transport phenomena describe the ways in which heat and matter move through their surroundings, for example, how heat radiates from a stove or how a scent fills the room. Exploring these dynamics outside Earth’s gravitational forces could lead to revolutionary advances in pharmaceuticals and other commercial applications.

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The Ring Sheared Drop system contains a concentrated solution of human serum albumin, allowing researchers to study fluid flow of biofluids in space.
The Ring Sheared Drop system contains a concentrated solution of human serum albumin, allowing researchers to study fluid flow of biofluids in space.
Credits: Joe Adam

Research to Test Cold Welding for Spacecraft Repairs

Imagine a spacecraft hurtling through deep space when suddenly, it’s struck by a rogue piece of space debris. In the harsh vacuum of space, traditional repair methods falter. Enter ASTROBEAT, an innovative experiment sponsored by the ISS National Laboratory, poised to advance spacecraft repairs using cold welding—a technique akin to patching a tire while soaring through space.

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The Nanolab Astrobeat module hull and core side by side.
Credits: Dr. Leonardo Barilaro, The Malta College of Arts, Science & Technology

Space-Based 3D Cell Culture Study Paves Way for New Cancer Therapies

In October, we think pink, and for a good reason—one out of every eight women will be diagnosed with breast cancer in their lifetime, and each year, 2 million women are given this frightening diagnosis. Biotechnology startup MicroQuin leveraged the International Space Station National Laboratory to grow 3D breast and prostate cancer cell cultures to learn more about how these cancers develop and grow. However, the research team found something incredible that could lead to a way to treat not just breast and prostate cancers but all cancers.

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NASA astronaut Christina Koch working on MicroQuin’s protein crystallization research on the ISS.
Credits: NASA