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Research Operations
& Integration

The Research Operations and Integration (ROI) element provides planning, integration, and implementation services for research tasks by NASA’s Human Research Program (HRP).

Learn More About ROI

ROI logo

About ROI

ROI is the implementation arm of HRP, developing efficient plans for conducting human research aboard the International Space Station and in spaceflight simulations.

NASA astronaut Megan McArthur participate an experiment from the European Space Agency that uses virtual reality gear and tests a crew member’s aptitude when maneuvering a computer-generated robotic arm toward a target.

Implementing Human Research

ROI determines how best to use spaceflight and ground-based spaceflight simulations to maximize research on the effects of long-duration spaceflight on human systems and the safeguards scientists are developing to protect crew health.

International Space Station


Take a look at the facilities – both on Earth in space – that ROI uses to conduct numerous scientific investigations concerning how the human body adapts to a spaceflight environment.

Meet the Team

Meet the team behind ROI, including element managers and scientists who help facilitate the research aboard the International Space Station and in simulations on Earth.

NASA astronaut Jasmin Moghbeli services microbe samples for DNA sequencing aboard the International Space Station.

Collaborate With HRP

Find different ways to collaborate with NASA’s HRP and help us discover how to keep the next generation of space explorers thriving on future missions to the Moon, Mars, and beyond.

Cross-Cutting Research Efforts

ROI supports the implementation of broad research campaigns that span HRP's elements. These include:

Complement of Integrated Protocols for Human Research (CIPHER)

NASA astronauts are returning to the Moon with plans for one day going to Mars. To better prepare astronauts for these long journeys, scientists need to know: How do extended durations in space change the human body?

Commander Alex Gerst conducts blood collection operations (OPS) for the Functional Immune and Standard Measures investigations. He is assisted by Flight Engineer (FE) Serena Auñón-Chancellor and observed by FE Anne McClain. Photo was taken in the Columbus European Laboratory.

Spaceflight Standard Measures

The project collects a core set measurements from astronauts throughout space station missions. This optimized, minimal set of measures is consistently captured from crewmembers to help characterize adaptive responses to and risks of living in space.

astronaut Akihiko Hoshide poses for a photo

Biological Specimen Repository

ROI has built a storage bank to maintain biological specimens over extended periods of time and under well-controlled conditions. This repository archives blood, urine, and other biosamples for use in future spaceflight-related research.

identical twin astronauts Mark and Scott Kelly

Twins Study

What physiological, molecular, and cognitive changes could happen to a human from exposure to spaceflight? Researchers compared retired astronaut Scott Kelly while he was in space, to his identical twin brother, retired astronaut Mark Kelly, who remained on Earth.

Steps to Mars

Explore the steps we are taking to prepare humans for long-duration spaceflight. We aim to combine insights from Earth-based simulations of life in space with research conducted on the space station and on future Artemis missions to get NASA ready to send crew to deep space.

Featured Story

The Human Body in Space

For more than 50 years, NASA’s Human Research Program (HRP) has studied what happens to the human body in space. Researchers…

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