NASA Space Biology Grant Scientific Articles

2016

Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.
Iwaniec UT, Philbrick KA, Wong CP, Gordon JL, Kahler-Quesada AM, Olson DA, Branscum AJ, Sargent JL, DeMambro VE, Rosen CJ, Turner RT. Osteoporos Int. 2016 May 17. [Epub ahead of print]
PMID: 27189604
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Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing? Hammond T, Allen P, Birdsall H. Pharm Res. 2016 May 16. [Epub ahead of print] Review.
PMID: 27183841
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A comparative cytogenetic study of Drosophila parasitoids (Hymenoptera, Figitidae) using DNA-binding fluorochromes and FISH with 45S rDNA probe. Gokhman VE, Bolsheva NL, Govind S, Muravenko OV. Genetica. 2016 May 5. [Epub ahead of print]
PMID: 27150102
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Spaceflight Activates Lipotoxic Pathways in Mouse Liver.
Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. PLoS One. 2016 Apr 20;11(4):e0152877. doi: 10.1371/journal.pone.0152877. eCollection 2016. Erratum in: PLoS One. 2016;11(5):e0155282. PMID: 27097220
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Microgravity Stress: Bone and Connective Tissue.  Bloomfield, S. A., Martinez, D. A., Boudreaux, R. D., & Mantri, A. V. (2016).  Compr Physiol, 6(2), 645-686. doi:10.1002/cphy.c130027
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A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells. Chowdhury, B., Seetharam, A., Wang, Z., Liu, Y., Lossie, A. C., Thimmapuram, J., & Irudayaraj, J. (2016). PLoS One, 11(1), e0147514. doi:10.1371/journal.pone.0147514
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Hindlimb unloading: Rodent analog for microgravity. Globus, R. K., & Morey-Holton, E. (2016).  J Appl Physiol (1985), jap.00997.02015. doi:10.1152/japplphysiol.00997.2015
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Long-Duration Bed Rest as an Analog to Microgravity. Hargens, A. R., & Vico, L. (2016).  J Appl Physiol (1985), jap.00935.02015. doi:10.1152/japplphysiol.00935.2015
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Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days).  Moyer, E. L., Dumars, P. M., Sun, G.-S., Martin, K. J., Heathcote, D. G., Boyle, R. D., & Skidmore, M. G. (2016). npj Microgravity, 2, 16002.
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Low-intensity vibrations accelerate proliferation and alter macrophage phenotype in vitro.  Pongkitwitoon, S., Weinheimer-Haus, E. M., Koh, T. J., & Judex, S. (2016).  J Biomech. doi:10.1016/j.jbiomech.2016.01.027
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Dried plum diet protects from bone loss caused by ionizing radiation.  Schreurs, A. S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G., . . . Globus, R. K. (2016).  Sci Rep, 6, 21343. doi:10.1038/srep21343.
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Space, the final frontier: A critical review of recent experiments performed in microgravity.  Vandenbrink, J. P., & Kiss, J. Z. (2016). Plant Sci, 243, 115-119. doi:10.1016/j.plantsci.2015.11.004
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Transient gene and microRNA expression profile changes of confluent human fibroblast cells in spaceflight.  Zhang, Y., Lu, T., Wong, M., Wang, X., Stodieck, L., Karouia, F., . . . Wu, H. (2016). Faseb j. doi:10.1096/fj.201500121
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2015

Identification of Putative Major Space Genes Using Genome-Wide Literature Data. Abdelmoaty, H., Hammond, T. G., Wilson, B. L., Birdsall, H. H., & Clement, J. Q. (2015).  InTech – Book Chapter.
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Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue.  Alwood, J. S., Shahnazari, M., Chicana, B., Schreurs, A. S., Kumar, A., Bartolini, A., …Globus, R. K. (2015).  J Interferon Cytokine Res. doi:10.1089/jir.2014.0152.
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Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles.  Baulch, J. E., Craver, B. M., Tran, K. K., Yu, L., Chmielewski, N., Allen, B. D., & Limoli, C. L. (2015). Redox Biol, 5, 24-32. doi:10.1016/j.redox.2015.03.001.
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Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth? Belavy, D. L., Adams, M., Brisby, H., Cagnie, B., Danneels, L., Fairbank, J., . . . Wilke, H. J. (2015).   Eur Spine J. doi:10.1007/s00586-015-3917-y.
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Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.  Berg-Johansen, B., Liebenberg, E. C., Li, A., Macias, B. R., Hargens, A. R., & Lotz, J. C. (2015).  J Orthop Res. doi:10.1002/jor.23029.
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Transcriptomes reveal alterations in gravity impact circadian clocks and activate mechanotransduction pathways with adaptation through epigenetic change.  Casey, T., Patel, O. V., & Plaut, K. (2015). Physiol Genomics (Vol. 47, pp. 113-128). United States: 2015 the American Physiological Society.
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Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. Chang, T. T., Spurlock, S. M., Candelario, T. L., Grenon, S. M., & Hughes-Fulford, M. (2015).   Faseb j. doi:10.1096/fj.15-275073.
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Microbiomes of the dust particles collected from the International Space Station and Spacecraft Assembly Facilities.  Checinska, A., Probst, A. J., Vaishampayan, P., White, J. R., Kumar, D., Stepanov, V. G., ….Venkateswaran, K. (2015).  Microbiome, 3(1), 50. doi:10.1186/s40168-015-0116-3.

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The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells. Chowdhury, B., McGovern, A., Cui, Y., Choudhury, S. R., Cho, I. H., Cooper, B.,…Irudayaraj, J. (2015).   Sci Rep, 5, 9281. doi:10.1038/srep09281.
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Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture.  Crabbe, A., Liu, Y., Sarker, S. F., Bonenfant, N. R., Barrila, J., Borg, Z. D., …Nickerson, C. A. (2015).  PLoS One (Vol. 10, pp. e0126846). United States.
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Methods for RNA profiling of gravi-responding plant tissues. Dalal, J., Land, E., Vasani, N., He, L., Smith, C., Rodriguez-Welsh, M., …Sederoff, H. (2015).   Methods Mol Biol, 1309, 91-117. doi:10.1007/978-1-4939-2697-8_9.
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Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line.  Dib, L. H., Ortega, M. T., Melgarejo, T., & Chapes, S. K. (2015).  Cytotechnology. doi:10.1007/s10616-015-9843-3.
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Genetic and Apoptotic Changes in Lungs of Mice Flown on the STS-135 Mission in Space. Gridley, D. S., Mao, X. W., Tian, J., Cao, J. D., Perez, C., Stodieck, L. S., …Pecaut, M. J. (2015).   In Vivo, 29(4), 423-433.
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Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.  Heslop, J. A., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., …Park, B. K. (2015).  Stem Cells Transl Med, 4(4), 389-400. doi:10.5966/sctm.2014-0110.
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Spaceflight alters expression of microRNA during T-cell activation.  Hughes-Fulford, M., Chang, T. T., Martinez, E. M., & Li, C. F. (2015). Faseb j. doi:10.1096/fj.15-277392.
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Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression.  Hwang, S. A., Crucian, B., Sams, C., Actor, J. K., & (Pecaut). (2015).  PLoS One, 10(5), e0124380. doi:10.1371/journal.pone.0124380.
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Morphometric analyses of petioles of seedlings grown in a spaceflight experiment. Johnson, C. M., Subramanian, A., Edelmann, R. E., & Kiss, J. Z. (2015).   J Plant Res. doi:10.1007/s10265-015-0749-0.
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Lifelong Wheel Running Exercise and Mild Caloric Restriction Attenuate Nuclear EndoG in the Aging Plantaris Muscle. Kim, J.-H., Lee, Y., Kwak, H.-B., & Lawler, J. M. (2015).   Experimental gerontology.
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Conducting plant experiments in space.  Kiss, J. Z. (2015).  Methods Mol Biol, 1309, 255-283. doi:10.1007/978-1-4939-2697-8_19.
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The effect of simulated microgravity on lumbar spine biomechanics: an in vitro study.  Laws, C. J., Berg-Johansen, B., Hargens, A. R., & Lotz, J. C. (2015).  Eur Spine J. doi:10.1007/s00586-015-4221-6.
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An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.  Lin, C. J., Smibert, P., Zhao, X., Hu, J. F., Ramroop, J., Kellner, S. M., …Lai, E. C. (2015).  RNA, 21(12), 2103-2118. doi:10.1261/rna.053934.115.
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Effects of angular frequency during clinorotation on mesenchymal stem cell morphology and migration.  Luna, C., Yew, A. G., & Hsieh, A. H. (2015).  Npj Microgravity, 1, 15007. doi:10.1038/npjmgrav.2015.7.
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Extending Rest between Unloading Cycles Does Not Enhance Bone’s Long-Term Recovery. Manske, S. L., Vijayaraghavan, S., Tuthill, A., Brutus, O., Yang, J., Gupta, S., & Judex, S. (2015). Med Sci Sports Exerc. doi:10.1249/mss.0000000000000636.
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Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Martinez, E. M., Yoshida, M. C., Candelario, T. T., & Hughes-Fulford, M. (2015). Am J Physiol Regul Integr Comp Physiol, ajpregu.00449.02014. doi:10.1152/ajpregu.00449.2014.
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Cardiac Deficiency of Single Cytochrome Oxidase Assembly Factor scox Induces p53 Dependent Apoptosis in a Drosophila Cardiomyopathy Model. Martinez-Morentin, L., Martinez, L., Piloto, S., Yang, H., Schon, E. A., Garesse, R., …Arredondo, J. J. (2015). Hum Mol Genet. doi:10.1093/hmg/ddv106.
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Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions. Mednieks, M., Khatri, A., & Hand, A. R. (2015). Gravitational and Space Research, 3(1).
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Is nitrous oxide a genotoxic carcinogen? O’Donovan, M. R., & Hammond, T. G. (2015). Mutagenesis, 30(4), 459-462. doi:10.1093/mutage/gev024.
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Paradoxical effects of partial leptin deficiency on bone in growing female mice. Philbrick, K. A., Turner, R. T., Branscum, A. J., Wong, C. P., & Iwaniec, U. T. (2015).   Anat Rec (Hoboken). doi:10.1002/ar.23267.
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Masticatory muscles of mouse do not undergo atrophy in space. Philippou, A., Minozzo, F. C., Spinazzola, J. M., Smith, L. R., Lei, H., Rassier, D. E., & Barton, E. R. (2015).   FASEB J. doi:10.1096/fj.14-267336.
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Neural response in vestibular organ of Helix aspersa to centrifugation and re-adaptation to normal gravity.  Popova, Y., & Boyle, R. (2015).  J Comp Physiol A Neuroethol Sens Neural Behav Physiol. doi:10.1007/s00359-015-1003-x.
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Effects of Hindlimb Unloading and Ionizing Radiation on Skeletal Muscle Resistance Artery Vasodilation and Its Relation to Cancellous Bone in Mice.  Prisby, R. D., Alwood, J. S., Behnke, B. J., Stabley, J. N., McCullough, D. J., Ghosh, P., ….Delp, M. D. (2015).  J Appl Physiol (1985), jap.00423.02015. doi:10.1152/japplphysiol.00423.2015.
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Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery. Prisby, R. D., Behnke, B. J., Allen, M. R., & Delp, M. D. (2015).   J Appl Physiol (1985), jap.00576.02014. doi:10.1152/japplphysiol.00576.2014.
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Spaceflight on the Bion-M1 Biosatellite Alters Cerebral Artery Vasomotor and Mechanical Properties in Mice. Sofronova, S. I., Tarasova, O. S., Gaynullina, D., Borzykh, A. A., Behnke, B. J., Stabley, J. N.,…Delp, M. D. (2015).  J Appl Physiol (1985), jap.00976.02014. doi:10.1152/japplphysiol.00976.2014.
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Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat.  Stabley, J. N., Prisby, R. D., Behnke, B. J., & Delp, M. D. (2015). J Endocrinol (Vol. 225, pp. 47-58). England: 2015 Society for Endocrinology.
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A self-referencing biosensor for real-time monitoring of physiological ATP transport in plant systems.  Vanegas, D. C., Clark, G., Cannon, A. E., Roux, S., Chaturvedi, P., & McLamore, E. S. (2015).  Biosens Bioelectron, 74, 37-44. doi:10.1016/j.bios.2015.05.027.
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The Vestibular System: A Newly Identified Regulator of Bone Homeostasis Acting Through the Sympathetic Nervous System. Vignaux, G., Besnard, S., Denise, P., & Elefteriou, F. (2015).   Curr Osteoporos Rep. doi:10.1007/s11914-015-0271-2.
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Bone shaft bending strength index is unaffected by exercise and unloading in mice. Wallace, I. J., Gupta, S., Sankaran, J., Demes, B., & Judex, S. (2015).   J Anat. doi:10.1111/joa.12277.
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Focal enhancement of the skeleton to exercise correlates with responsivity of bone marrow mesenchymal stem cells rather than peak external forces.  Wallace, I. J., Pagnotti, G. M., Rubin-Sigler, J., Naeher, M., Copes, L. E., Judex, S., …Demes, B. (2015).  J Exp Biol, 218(Pt 19), 3002-3009. doi:10.1242/jeb.118729.
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Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection. Yang, J., Barrila, J., Roland, K. L., Kilbourne, J., Ott, C. M., Forsyth, R. J., & Nickerson, C. A. (2015).   PLoS Negl Trop Dis, 9(6), e0003839. doi:10.1371/journal.pntd.0003839.
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2014

Mice in Bion-M 1 space mission: training and selection.  Andreev-Andrievskiy, A., Popova, A., Boyle, R., Alberts, J., Shenkman, B., Vinogradova, O., …Sychev, V. (2014).  PLoS One, 9(8), e104830. doi:10.1371/journal.pone.0104830.
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Biomechanical Aspects of the Muscle-Bone Interaction.  Avin, K. G., Bloomfield, S. A., Gross, T. S., & Warden, S. J. (2014).  Curr Osteoporos Rep. doi:10.1007/s11914-014-0244-x.
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Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.  Nislow C, Lee AY, Allen PL, Giaever G, Smith A, Gebbia M, Stodieck LS, Hammond JS, Birdsall HH, Hammond TG. (2014). Biomed Res Int.([in press]).
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Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates.  Chang, T. T., & Hughes-Fulford, M. (2014).  Biomaterials, 35(7), 2162-2171. doi:10.1016/j.biomaterials.2013.11.063.
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Combined effects of botulinum toxin injection and hind limb unloading on bone and muscle. Ellman, R., Grasso, D. J., van Vliet, M., Brooks, D. J., Spatz, J. M., Conlon, C., & Bouxsein, M. L. (2014). Calcif Tissue Int, 94(3), 327-337. doi:10.1007/s00223-013-9814-7
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A Tissue Retrieval and Postharvest Processing Regimen for Rodent Reproductive Tissues Compatible with Long-Term Storage on the International Space Station and Postflight Biospecimen Sharing Program. Gupta, V., Holets-Bondar, L., Roby, K. F., Enders, G., & Tash, J. S. (2014). BioMed Research International.
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Effects of sex and gender on adaptation to space: immune system.  Kennedy, A. R., Crucian, B., Huff, J. L., Klein, S. L., Morens, D., Murasko, D., …Sonnenfeld, G. (2014).  J Womens Health (Larchmt), 23(11), 956-958. doi:10.1089/jwh.2014.4913.
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Upper extremity hemodynamics and sensation with backpack loads. Kim, S. H., Neuschwander, T. B., Macias, B. R., Bachman, L., Jr., & Hargens, A. R. (2014).   Appl Ergon, 45(3), 608-612. doi:10.1016/j.apergo.2013.08.005.
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Plant biology in reduced gravity on the Moon and Mars.  Kiss, J. Z. (2014).  Plant Biol (Stuttg), 16 Suppl 1, 12-17. doi:10.1111/plb.12031.
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EUK-134 ameliorates nNOSmu translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. Lawler, J. M., Kunst, M., Hord, J. M., Lee, Y., Joshi, K., Botchlett, R. E., …Martinez, D. A. (2014).  Am J Physiol Regul Integr Comp Physiol (Vol. 306, pp. R470-482). United States.
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Quantitative trait loci that modulate trabecular bone’s risk of failure during unloading and reloading.  Ozcivici, E., Zhang, W., Donahue, L. R., & Judex, S. (2014). Bone, 64, 25-32. doi:10.1016/j.bone.2014.03.042.
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Mapping by VESGEN of leaf venation patterning in Arabidopsis thaliana with bioinformatic dimensions of gene expression.  P, P.-W., MB, V., AL, P., & RJ, F. (2014).  Gravitational and Space Research, 2(1), 68-81.
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Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.  Qin, Q., Xie, H., Wise, S. S., Browning, C. L., Thompson, K. N., Holmes, A. L., & Wise, J. P., Sr. (2014). Toxicol Sci, 142(1), 117-125. doi:10.1093/toxsci/kfu175.
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Altered disc compression in children with idiopathic low back pain: an upright magnetic resonance imaging backpack study. Shymon, S. J., Yaszay, B., Dwek, J. R., Proudfoot, J. A., Donohue, M., & Hargens, A. R. (2014).   Spine (Phila Pa 1976), 39(3), 243-248. doi:10.1097/brs.0000000000000114.
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Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. Tseng, B. P., Giedzinski, E., Izadi, A., Suarez, T., Lan, M. L., Tran, K. K., …Limoli, C. L. (2014).   Antioxid Redox Signal, 20(9), 1410-1422. doi:10.1089/ars.2012.5134.
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International Space Station environmental microbiome – microbial inventories of ISS filter debris. Venkateswaran, K., Vaishampayan, P., Cisneros, J., Pierson, D. L., Rogers, S. O., & Perry, J. (2014).   Appl Microbiol Biotechnol, 98(14), 6453-6466. doi:10.1007/s00253-014-5650-6.
Click here to read the abstract.

Inner ear vestibular signals regulate bone remodeling via the sympathetic nervous system.  Vignaux, G., Ndong, J., Perrien, D., & Elefteriou, F. (2014).  J Bone Miner Res. doi:10.1002/jbmr.2426.
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Proximity within interphase chromosome contributes to the breakpoint distribution in radiation-induced intrachromosomal exchanges. Zhang, Y., Uhlemeyer, J., Hada, M., Asaithamby, A., Chen, D. J., & Wu, H. (2014).   Life Sciences in Space Research, 2, 23-28.

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Effects of load-bearing exercise on skeletal structure and mechanics differ between outbred populations of mice. Wallace IJ, Judex S, Demes B. Bone. 2014 Nov 22;72C:1-8. doi: 10.1016/j.bone.2014.11.013. [Epub ahead of print]
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Stem cell health and tissue regeneration in microgravity.  Blaber E, Sato K, Almeida EA. Stem Cells Dev. 2014 Dec;23 Suppl 1:73-8. doi: 10.1089/scd.2014.0408.  PMID: 25457968 [PubMed – in process]
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Light and gravity signals synergize in modulating plant development.  Vandenbrink JP, Kiss JZ, Herranz R, Medina FJ.  Front Plant Sci. 2014 Oct 28;5:563. doi: 10.3389/fpls.2014.00563. eCollection 2014. Review.  PMID: 25389428 [PubMed]
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High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core “DSB” response specific to clastogenic treatments.  Missirian V, Conklin PA, Culligan KM, Huefner ND, Britt AB. Front Plant Sci. 2014 Aug 1;5:364. doi: 10.3389/fpls.2014.00364. eCollection 2014. PMID: 25136344 [PubMed]
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Microbial existence in controlled habitats and their resistance to space conditions. Venkateswaran K, T La Duc M, Horneck G.  Microbes Environ. 2014 Aug 12. [Epub ahead of print] Review.
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Sigma S-dependent antioxidant defense protects stationary phase Escherichia coli against the bactericidal antibiotic gentamicin. Wang JH, Singh R, Benoit M, Keyhan M, Sylvester M, Hsieh M, Thathireddy A, Hsieh YJ, Matin AC.  Antimicrob Agents Chemother. 2014 Jul 28. pii: AAC.03683-14. [Epub ahead of print]. 
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Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice. Bailey, J, Hargens, A, Cheng, K, Lotz, J.  J. of Biomechanics, July 2014.
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MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG, Lawler JM. J Gerontol A Biol Sci Med Sci. 2014 Jul 11. pii: glu090.
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Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. Turner RT, Philbrick KA, Wong CP, Olson DA, Branscum AJ, Iwaniec U.  J Endocrinol. 2014 Jul 2. pii: JOE-14-0224
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Absence of ɣ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle. Morwood, C., Philippou, A., Spinazzola, J., Keyser, B., Macarak, E., Barton, E.  Skeletal Muscle 2014, 4:13.
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Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response. Soni A, O’Sullivan L, Quick LN, Ott CM, Nickerson CA, Wilson JW. Open Microbiol J. 2014 Jun 13;8:51-8.
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Microgravity alters the expression of salivary proteins. Mednieks M, Khatri A, Rubenstein R, Burleson JA, Hand AR.   Oral Health Dent Manag. 2014 Jun;13(2):211-6.
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Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa. Crabbe A, Ledesma MA, Nickerson CA.  Pathog Dis. 2014 Jun;71(1):1-19. Epub 2014 May 23.
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Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism. de Regt AK, Yin Y, Withers TR, Wang X, Baker TA, Sauer RT, Yu HD.  Mol Microbiol. 2014 Jun 10. [Epub ahead of print]
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Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration. Blaber, E.A., Dvorochkin, N., Torres, M.L., Yousuf, R., Burns,.P., Globus, R.K., Almeida, E.A.C. Stem Cell Research (2014), doi: 10.1016/j.scr.2014.05.005.
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Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana. Huefner ND, Yoshiyama K, Friesner JD, Conklin PA, Britt AB. Front Plant Sci. 2014 May 20;5:206. doi: 10.3389/fpls.2014.00206. eCollection 2014.
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Trabecular Bone Recovers from Mechanical Unloading Primarily by Restoring its Mechanical Function rather than its Morphology. Ozcivici E, Judex S. Bone. 2014 May 21. doi: 10.1016/j.bone.2014.05.009.
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Biological and Metabolic Response in STS-135 Space-flown Mouse Skin.  Mao XW, Pecaut MJ, Stodieck LS, Ferguson VL, Bateman TA, Bouxsein ML, Gridley DS.  Free Radic Res. 2014 May 6.
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Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle. Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak EJ, Barton ER.  Skelet Muscle. 2014 Jul 1;4:13.
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Host-microbe interactions in microgravity: Assessment and implications. Foster, J, Wheeler, R, Pamphile, R.  Life 2014, 4, 250-266; doi:10.3390/life4020250.
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The Effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment. Latchney S, Rivera P, Mao X, Ferguson V, Bateman T, Stodieck L, Nelson G, Eisch, A. J Appl Physiol (April 17, 2014).
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Changes in operational procedures to improve spaceflight experiments in plant biology in the European Modular Cultivation System. Kiss JZ, Aanes G, Schiefloe M, Coelho LH, Millar KD, Edelmann RE.  Adv Space Res. 2014 Mar;53(5):818-27.
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Quantitative trait loci that modulate trabecular bone’s risk of failure during unloading and reloading. Ozcivici, E., Zhang, W., Donahue, L., Judex, S. Bone. 03/2014; DOI:10.1016/j.bone.2014.03.042. 
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Exercise Training Augments Regional Bone and Marrow Blood Flow During Exercise. Stabley JN, Moningka NC, Behnke BJ, Delp MD.   Med Sci Sports Exerc. 2014 Mar 20.  
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Lab-on-Chip Clinorotation System for Live-Cell Microscopy Under Simulated Microgravity. Yew AG, Atencia J, Hsieh, A. Cellular and Mol Bioengineering. March 2014; 7 (1) 165-170.
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Toll mediated infection response is altered by gravity and spaceflight in Drosophila.  Taylor K, Kleinhesselink K, George MD, Morgan R, Smallwood T, Hammonds AS, Fuller PM, Saelao P, Alley J, Gibbs AG, Hoshizaki DK, von Kalm L, Fuller CA, Beckingham KM, Kimbrell DA.  PLoS One. 2014;9(1):e86485.
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2013

Endomembrane and Golgi traffic in plant cells. Stefano G, Osterrieder A, Hawes C, Brandizzi F. Methods Cell Biol. 2013;118:69-83.
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Spaceflight Enhances Cell Aggregation and Random Budding in Candida albicans. Crabbé A, Nielsen-Preiss SM, Woolley CM, Barrila J, Buchanan K, McCracken J, Inglis DO, Searles SC, Nelman-Gonzalez MA, Ott CM, Wilson JW, Pierson DL, Stefanyshyn-Piper HM, Hyman LE, Nickerson CA.  PLoS One. 2013 Dec 4;8(12):e80677. doi: 10.1371/journal.pone.0080677.
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Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle. Sung M, Li J, Spieker AJ, Spatz J, Ellman R, Ferguson VL, Bateman TA, Rosen GD, Bouxsein M, Rutkove SB.  J Musculoskelet Neuronal Interact. 2013 Dec;13(4):405-11.
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Combined effects of botulinum toxin injection and hind limb unloading on bone and muscle.  Ellman R, Grasso DJ, van Vliet M, Brooks DJ, Spatz JM, Conlon C, Bouxsein ML.  Calcif Tissue Int. 2013 Nov 17.
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Increasing the number of unloading/reambulation cycles does not adversely impact body composition and lumbar bone mineral density but reduces tissue sensitivity.  Gupta S, Manske SL, Judex S. Acta Astronaut. 2013 Nov;92(1):89-96.
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Inter-regulation of the unfolded protein response and auxin signaling. Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzi F. Plant J. 2013 Nov 4. [Epub ahead of print]
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Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice. Dib LH, Ortega MT, Fleming SD, Chapes SK, Melgarejo T. Endocrinology. 2013 Oct 29. [Epub ahead of print]
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Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability. Kim W, Tengra F, Shong J, Marchand N, Chan HK, Young Z, Pangule R, Parra M, Dordick J, Plawsky J, Collins C. BMC Microbiology. 2013 13:241.
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Chronic skeletal unloading of the rat femur: Mechanisms and functional consequences of vascular remodeling. Stabley JN, Prisby RD, Behnke BJ, Delp MD. Bone. 2013 Sep 19. [Epub ahead of print]
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Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana. Kim SJ, Bassham DC. BMC Biochem. 2013 Sep 11;14:22.
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Amyloplast displacement is necessary for gravisensing in Arabidopsis shoots as revealed by a centrifuge microscope. Toyota M, Ikeda N, Sawai-Toyota S, Kato T, Gilroy S, Tasaka M, Morita MT. Plant J. 2013 Oct 14;76;648-660.
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Spaceflight environment induces mitochondrial oxidative damage in ocular tissue. Mao XW, Pecaut MJ, Stodieck LS, Ferguson VL, Bateman TA, Bouxsein M, Jones TA, Moldovan M, Cunningham CE, Chieu J, Gridley DS. Radiat Res. 2013 Oct;180;4;340-350.
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Analysis of unfolded protein response in Arabidopsis. Chen Y, Brandizzi F. Methods Mol Biol. 2013;1043:73-80.
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Increasing the number of unloading/reambulation cycles does not adversely impact body composition and lumbar bone mineral density but reduces tissue sensitivity. Gupta S, Manske SL, Judex S. Acta Astronaut. 2013 Nov;92(1):89-96.
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A method for preparing spaceflight RNAlater-fixed Arabidopsis thaliana (Brassicaceae) tissue for scanning electron microscopy. Schultz ER, Kelley KL, Paul A-L, Ferl RJ. Appl Plant Sci. 2013 Aug;1(8):1300034.
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The actin cytoskeleton is a suppressor of the endogenous skewing behaviour of Arabidopsis primary roots in microgravity. Nakashima J, Liao F, Sparks JA, Tang Y, Blancaflor EB. Plant Biol (Stuttg). 2013 Aug 16. doi: 10.1111/plb.12062. [Epub ahead of print]
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Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight. Paul AL, Zupanska AK, Schultz ER, Ferl RJ. BMC Plant Biology. 2013 Aug 7, 13:112 doi:10.1186/1471-2229-13-112
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Functional Consequences of Radiation-Induced Oxidative Stress in Cultured Neural Stem Cells and the Brain Exposed to Charged Particle Irradiation. Tseng BP, Giedzinski E, Izadi A, Suarez T, Lan ML, Tran KK, Acharya MM, Nelson GA, Raber J, Parihar VK, Limoli CL. Antioxid Redox Signal. 2013 Aug 12. [Epub ahead of print]
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Plant biology in reduced gravity on the Moon and Mars. Kiss JZ. Plant Biol (Stuttg). 2013 Jul 25. doi: 10.1111/plb.12031. [Epub ahead of print]
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IRE1: ER stress sensor and cell fate executor. Chen, Y. and Brandizzi, F. Trends in Cell Biology. 22 July 2013.
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Genetic loci that control the loss and regain of trabecular bone during unloading and reambulation. Judex S, Zhang W, Donahue LR, Ozcivici E. J Bone Miner Res. 2013 Jul;28(7):1537-49. doi: 10.1002/jbmr.1883.
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Multiparameter Behavioral Analyses Provide Insights to Mechanisms of Cyanide Resistance in Caenorhabditis elegans. Saldanha JN, Parashar A, Pandey S, Powell-Coffman JA. Toxicol Sci. 2013 Sep;135(1):156-68. doi: 10.1093/toxsci/kft138. Epub 2013 Jun 26.
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Fifteen days of microgravity causes growth in calvaria of mice. Zhang B, Cory E, Bhattacharya R, Sah R, Hargens A. Bone. 2013 Jun 20;56(2):290-295. doi: 10.1016/j.bone.2013.06.009.
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Transcriptome analyses of Arabidopsis thaliana seedlings grown in space: implications for gravity-responsive genes. Correll MJ, Pyle TP, Millar KDL, Sun Y, Yao J, Edelmann RE, and Kiss JZ. Planta. June 2013. DOI 10.1007/s00425-013-1909-x
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Organization of the ER-Golgi interface for membrane traffic control. Brandizzi F, Barlowe C. Nature Reviews Molecular Cell Biology. 2013 Jun;14(6):382-92. doi: 10.1038/nrm3588.
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Back pain in space and post-flight spine injury: Mechanisms and countermeasure development. Sayson JV, Lotz J, Parazynski S, Hargens AR. Acta Astronautica. Volume 86, May–June 2013, Pages 24–38.
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Imaging changes in cytoplasmic calcium using the Yellow Cameleon 3.6 biosensor and confocal microscopy. Swanson SJ, Gilroy S. Methods Mol Biol. 2013;1009:291-302. doi: 10.1007/978-1-62703-401-2_27.
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Development and characterization of two porcine monocyte-derived macrophage cell lines. Chitko-McKown CG, Chapes SK, Miller LC, Riggs PK, Ortega MT, Green BT, McKown RD. Results Immunol. 2013;3:26-32.
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Spaceflight Promotes Biofilm Formation by Pseudomonas aeruginosa. Kim W, Tengra F, Young Z, Shong J, Marchand N, Chan H, Pangule R, Parra M, Dordick J, Plawsky J, Collins C. PLoS One. 8(4): e62437. doi:10.1371/journal.phone.0062437. April 29, 2013.
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The drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors. Bjorum SM, Simonette RA, Alanis R Jr, Wang JE, Lewis BM, Trejo MH, Hanson KA, Beckingham KM. PLoS One. 2013 Apr 19;8(4):e61270. doi: 10.1371/journal.pone.0061270. Print 2013.
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Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research. Wan Salim WW, Zeitchek MA, Hermann AC, Ricco AJ, Tan M, Selch F, Fleming E, Bebout BM, Bader MM, Ul Haque A, Porterfield DM. J Vis Exp. 2013 Apr 18;(74). doi: 10.3791/50020.
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Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21. Blaber EA, Dvorochkin N, Lee C, Alwood JS, Yousuf R, Pianetta P, Globus RK, Burns BP, Almeida EA. PLoS One. 2013 Apr 18;8(4):e61372. doi: 10.1371/journal.pone.0061372. Print 2013.
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Understanding Macrophage Differentiation During Space Flight: The Importance of Ground-Based Experiments Before Space Flight. Chapes SK, and Ortega MT. Recent Patents on Space Technology. 2013; 3(1):40-47. DOI: 10.2174/18776116112029990011
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Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. J Bone Miner Res. 2013 Apr;28(4):875-85.
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Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading.Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Suva LJ, Dwyer D, Stolina M, Ke HZ, Bouxsein ML. J Bone Miner Res. 2013 Apr;28(4):865-74.
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Phototropism of Arabidopsis thaliana in microgravity and fractional gravity on the International Space Station. Kiss JZ, Millar KD, Edelmann RE. Planta. 2012 Aug;236(2):635-45. doi: 10.1007/s00425-012-1633-y. Epub 2012 Apr 6.
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Low-intensity vibrations partially maintain intervertebral disc mechanics and spinal muscle area during deconditioning. Holguin N, Martin JT, Elliott DM, Judex S. Spine J. 2013 Apr;13(4):428-36. doi: 10.1016/j.spinee.2013.01.046. Epub 2013 Mar 15.
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Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Sci Rep. 2013;3:1494. doi: 10.1038/srep01494.
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Deployment of a fully-automated green fluorescent protein imaging system in a high arctic autonomous greenhouse. Abboud T, Bamsey M, Paul AL, Graham T, Braham S, Noumeir R, Berinstain A, Ferl R. Sensors (Basel). 2013 Mar 13;13(3):3530-48. doi: 10.3390/s130303530.
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Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure. Taylor CR, Hanna M, Behnke BJ, Stabley JN, McCullough DJ, Davis RT 3rd, Ghosh P, Papadopoulos A, Muller-Delp JM, Delp MD. FASEB J. 2013 Jun;27(6):2282-92. doi: 10.1096/fj.12-222687. Epub 2013 Mar 1.
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Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity. Yang LM, Zhong D, Blount P. Cell Rep. 2013 Feb 21;3(2):520-7. doi: 10.1016/j.celrep.2013.01.018. Epub 2013 Feb 14.
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Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation. Davis RT 3rd, Stabley JN, Dominguez JM 2nd, Ramsey MW, McCullough DJ, Lesniewski LA, Delp MD, Behnke BJ. J Appl Physiol. 2013 Mar 15;114(6):808-15. doi: 10.1152/japplphysiol.01358.2012. Epub 2013 Jan 24.
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Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Drolia R, Von Ohlen T, Chapes SK. Int J Med Microbiol. 2013 Jan;303(1):40-9. doi: 10.1016/j.ijmm.2012.12.002. Epub 2013 Jan 8.
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Fundamental plant biology enabled by the space shuttle. Paul AL, Wheeler RM, Levine HG, Ferl RJ. Am J Bot. 2013 Jan;100(1):226-34. doi: 10.3732/ajb.1200338. Epub 2013 Jan 1.
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Gravity persistent signal 1 (GPSI) reveals novel cytochrome P450x involved in gravitropism. Withers JC, Shipp MJ, Rupasinghe SG, Sukumar P, Schuler MA, Muday GK, Wyatt SE. Am J Bot. 2013 Jan;100(1):183-193. doi: 10.3732/ajb.1200436
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Gravitropism and mechanical signaling in plants. Toyota M, Gilroy S. Am J Bot. 2013 Jan;100(1):111-25. doi: 10.3732/ajb.1200408. Epub 2013 Jan 1.
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Plant tropisms: from Darwin to the International Space Station. Wyatt SE, Kiss JZ. Am J Bot. 2013 Jan;100(1):1-3. doi: 10.3732/ajb.1200591. Epub 2013 Jan 1.
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2012

Using the Moon as a high-fidelity analogue environment to study biological and behavioral effects of long-duration space exploration. Goswami N, Roma PG, De Boever P, Clément G, Hargens AR, Loeppky JA, Evans JM, Stein TP, Blaber AP, Van Loon JJ, Mano T, Iwase S, Reitz G, Hinghofer-Szalkay HG. Planet Space Sci. 2012 Dec;74(1):111-20.
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Spaceflight engages heat shock protein and other molecular chaperone genes in tissue culture cells of Arabidopsis thaliana. Zupanska AK, Denison FC, Ferl RJ, Paul AL. Am J Bot. 2013 Jan;100(1):235-48. doi: 10.3732/ajb.1200343. Epub 2012 Dec 20.
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A role for lipid-mediated signaling in plant gravitropism.Smith CM, Desai M, Land ES, Perera IY. Am J Bot. 2013 Jan;100(1):153-60. doi: 10.3732/ajb.1200355. Epub 2012 Dec 20.
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Plant growth strategies are remodeled by spaceflight. Paul AL, Amalfitano CE, Ferl RJ. BMC Plant Biol. 2012 Dec 7;12:232. PMID: 23217113
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Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia. Iwaniec UT, Turner RT. Bone. 2012 Dec 12;53(1):145-53. PMID: 23246792
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Analyses of tropistic responses using metabolomics. Millar KD, Kiss JZ. Am J Bot. 2013 Jan;100(1):79-90. doi: 10.3732/ajb.1200316. Epub 2012 Nov 28.
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Analysis of magnetic gradients to study gravitropism. Hasenstein KH, John S, Scherp P, Povinelli D, Mopper S. Am J Bot. 2013 Jan;100(1):249-55. doi: 10.3732/ajb.1200304. Epub 2012 Nov 21.
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Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling. Prisby RD, Dominguez JM 2nd, Muller-Delp J, Allen MR, Delp MD. PLoS One. 2012;7(11):e48564. Epub 2012 Nov 20.
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Testing the bio-compatibility of aluminum PDFU BRIC hardware. Schultz ER, Zupanska AK, Manning-Roach S, Camacho J, Levine H, Paul AL, Ferl RJ. Gravitational and Space Biology. 2012 Oct;26 (2):48-63.
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Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice. Behnke BJ, Stabley JN, McCullough DJ, Davis RT 3rd, Dominguez JM 2nd, Muller-Delp JM, Delp MD. FASEB J. 2013 Jan;27(1):399-409. doi: 10.1096/fj.12-218503. Epub 2012 Oct 25.
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Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. Hargens AR, Bhattacharya R, Schneider SM. Eur J Appl Physiol. 2013 Sep;113(9):2183-92. doi: 10.1007/s00421-012-2523-5. Epub 2012 Oct 19.
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Post-spaceflight recovery of biomechanical properties of murine intervertebral discs. Bailey JF, Hargens AR, Cheng KK, Lotz JC. Gravitational and Space Biol. 2012 Oct;26(2):38-47.
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Maximizing information from space data resources: a case for expanding integration across research disciplines. Goswami N, Batzel JJ, Clément G, Stein TP, Hargens AR, Sharp MK, Blaber AP, Roma PG, Hinghofer-Szalkay HG. Eur J Appl Physiol. 2013 Jul;113(7):1645-54. doi: 10.1007/s00421-012-2507-5. Epub 2012 Oct 17.
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RNA-seq analysis identifies potential modulators of gravity response in spores of Ceratopteris (Parkeriaceae): evidence for modulation by calcium pumps and apyrase activity. Bushart TJ, Cannon AE, Ul Haque A, San Miguel P, Mostajeran K, Clark GB, Porterfield DM, Roux SJ. Am J Bot. 2013 Jan;100(1):161-74. doi: 10.3732/ajb.1200292. Epub 2012 Oct 9.
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Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1354-62. doi: 10.1152/ajpendo.00330.2012. Epub 2012 Oct 9.
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Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology. Behnke BJ, Ramsey MW, Stabley JN, Dominguez JM 2nd, Davis RT 3rd, McCullough DJ, Muller-Delp JM, Delp MD. J Appl Physiol. 2012 Dec 1;113(11):1699-708. doi: 10.1152/japplphysiol.01025.2012. Epub 2012 Oct 4.
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Regulation of plant gravity sensing and signaling by the actin cytoskeleton. Blancaflor EB. Am J Bot. 2013 Jan;100(1):143-52. doi: 10.3732/ajb.1200283. Epub 2012 Sep 21.
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Estimating the speed of Drosophila locomotion using an automated behavior detection and analysis system. Chan KL, Inan O, Bhattacharya S, Marcu O. Fly (Austin). 2012 Jul-Sep;6(3):205-10. doi: 10.4161/fly.20987. Epub 2012 Jul 1.
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Oxidative and nutrient stability of a standard rodent spaceflight diet during long-term storage. Sun GS, Tou JC, Reiss-Bubenheim DA, Hill EL, Liittschwager KW, Girten BE, Pena-Yewkukhiw E. Lab Anim (NY). 2012 Aug 22;41(9):252-9. doi: 10.1038/laban0912-252.
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Regulation of eIF2α phosphorylation in hindlimb-unloaded and STS-135 space-flown mice. Zhao L, Tanjung N, Swarnkar G, Ledet E, Yokota H. Advances in Space Research. 2012 Sep 1;50(5):576-83.
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A sparse matrix approach for simultaneous quantification of nystagmus and saccade. Kukreja SL, Stone LS, Boyle RD. Conference Proceedings IEEE Eng Med Biol Soc. 2012 Aug;2012:5478-81.
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Effects of aging, TNF-α, and exercise training on angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles. Park Y, Prisby RD, Behnke BJ, Dominguez JM 2nd, Lesniewski LA, Donato AJ, Muller-Delp J, Delp MD. J Appl Physiol. 2012 Oct;113(7):1091-100. doi: 10.1152/japplphysiol.00292.2012. Epub 2012 Aug 23.
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Hypergravity disruption of homeorhetic adaptations to lactation in rat dams include changes in circadian clocks. Casey T, Zakrzewska EI, Maple RL, Lintault L, Wade CE, Baer LA, Ronca AE, Plaut K. Biology Open. 2012 Jun 15;1(6):570-81. Epub 2012 Apr 30.
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