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Stephanie A. Puukila

Stephanie A. Puukila

Research Scholar

Contents

Email: stephanie.a.puukila@nasa.gov
Affiliation: Blue Marble Space Institute of Science; NASA Ames Space Biosciences Research Branch

Biography

Stephanie Puukila received her PhD in Biotechnology in Medicine at Lakehead University. Her research topic of interest is the role of oxidative stress in radiation exposure and the development of antioxidant countermeasures. Currently, she is a postdoctoral fellow as part of the NASA Postdoctoral Program through Oak Ridge Associated Universities. She is investigating the neurobiological and neurobehavioral effects of space environment stressors including galactic cosmic radiation exposure, microgravity and social isolation as part of the NASA Human Research Program- funded project titled ‘Oxidative stress and the neuroconsequences of spaceflight environment – Immune dysregulation and antioxidant dietary countermeasure efficacy.’ Additionally, she is a Co-Investigator on upcoming rodent spaceflight studies Rodent Research 20 and researcher on Rodent Research 26.

Education

PhD, Biotechnology in Medicine, Lakehead University

MSc, Biology, Lakehead University

HBSc, Appl Bio-Molecular, Lakehead University

Publications

  1. Puukila S, Siu O, Rubinstein L, Tahimic CGT, Lowe M, Tabares Ruiz S, Korostenskij I, Semel M, Iyer J, Mhatre SD, Shirazi-Fard Y, Alwood JS, Paul AM, Ronca AE. Galactic Cosmic Irradiation Alters Acute and Delayed Species-Typical Behavior in Male and Female Mice. Life (Basel), 2023. doi: 10.3390/life13051214
  2. Puukila S, Lawrence MD, De Pasquale CG, Bersten AD, Bihari S, Nemec-Bakk A, Dixon D-L. Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor (CCR2) in lung leukocyte infiltration and activation in Chronic Heart Failure patients. Cytokine, 2023. doi: 10.1016/j.cyto.2022.156060
  3. Rubinstein L, Kiffer F, Puukila S, Lowe MG, Goo B, Luthens A, Schreurs AS, Torres SM, Steczina S, Tahimic CGT, Allen AR. Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus. Life, 2022. doi: 10.3390/life12111838.
  4. Mhatre S, Iyer J, Puukila S, Paul A, Tahimic C, Rubinstein L, Lowe M, Alwood J, Sowa M, Bhattacharya S, Globus R, Ronca A. Neuroconsequences of the Spaceflight Environment. Neuroscience and Behavioral Reviews, 2022. doi: 10.1016/j.neubiorev.2021.09.055
  5. Puukila S, Thanrmalingam S, Al-Khayyat W, Peterson J, Hooker AM, Muise S, Boreham DR, Dixon D-L. Transcriptomic Response in the spleen after whole-body low dose X-ray irradiation. Radiation Research, 2021, doi: 10.1667/RADE-20-00267.1
  6. Puukila S, Haigh P, Johnston A, Boreham DR, Hooker AM, Dixon D-L. A radon chamber specifically designed for environmentally relevant exposures of small animals. Journal of Environmental Radioactivity, 2020; 220-221, 106295.
  7. Puukila S, Muise S, McEvoy J, Bouchier T, Hooker AM, Boreham DR, Khaper N, Dixon D-L. Acute Pulmonary and Splenic Response in an in vivo Model of Whole-body Low-dose X-radiation Exposure. International Journal of Radiation Biology, 2019; 1072-1084.
  8. Puukila S, Thome C, Brooks AL, Woloschak G, Boreham DR. The Influence of Changing Dose Rate Patterns from Inhaled Beta-Gamma Emitting Radionuclide on Lung Cancer. International Journal of Radiation Biology, 2018; 955-966.
  9. Puukila S, Lemon J, Lees S, Tai TC, Boreham D. Khaper N. Impact of ionizing radiation on the cardiovascular system: A review. Radiation Research, 2017; 539-546.
  10. Puukila S, Thome C, Brooks AL, Woloschak G, Boreham DR. The role of radiation induced injury on lung cancer. Cancers, 2017; 89.
  11. Puukila S, Fernandes RO, Turck P, Carraro CC, Bonetto JH, de Lima-Seolin BG, Araujo AS, Belló-Klein A, Boreham D, Khaper N. Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline induced right heart dysfunction. Molecular and Cellular Biochemistry, 2017.
  12. Puukila S, Forsyth HL, Singal PK and Khaper N. Effect of secoisolariciresinol diglucoside on antioxidant response in an in vitro iron overload condition. In: Adaptation Biology and Medicine: Current Trends. Eds. Y. Kawai, A.R. Hargens and P.K. Singal. Narosa Publishing House, Vol. 8, 2017.
  13. Puukila S, Bryan S, Laakso AM, Abdel-Malak J, Gurney C, Agostino A, Prasad K, Khaper N. Secoisolariciresinol diglucoside abrogates oxidative stress-induced cytotoxicity in an in vitro model of cardiac iron overload. PLOS ONE, 2015.
  14. Fernandes RO, Bonetto JH, Baregzay B, de Castro AL, Puukila S, Forsyth H, Schenkel PC, Llesuy SF, Brum IS, Araujo AS, Khaper N, Belló-Klein A. Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiomyoblasts. Molecular and Cellular Biochemistry, 2014; 61-70.
  15. Fonseca E, Puukila S, Eichler R, Barbosa AM, Dekker R, Fortes Z. Khaper N. Metformin induces apoptosis and cell cycle arrest mediated by AMPK and FOXO3a in MCF-7 breast cancer cells. PLoS One, 2014.
  16. • Hassan H, Jiang ZH, Khaper N, Puukila S, Asmussan C, McDonald E, Qin W. Antioxidant Activity of Northern Ontario Medicinal Plants and Their Protective Effect on the H9c2 Cardiovascular Cells Against Hydrogen Peroxide Mediated Oxidative Stress. The Journal of Ethnobiology and Traditional Medicine, 2014; 820-31.
  17. • Ross B, Puukila S, Lecours M, Agostino A, Khaper N. The use of SIFT-MS to investigate headspace aldehydes as markers of lipid peroxidation. Current Analytical Chemistry, 2012; 9: 600-13(14).
  18. • Yang G, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L, Wang R. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal, 2012; 18: 1906-19.
  19. • Mallik A, Bryan S, Puukila S, Chen A, Khaper N. Efficacy of platinum modified titanium dioxide nanoparticles in cardiomyocytes. Exptl and Clin Cardiol. 2011; 16: 6-10.