CV Risk Narrative DAG CM Final - Errata 20220311


dag {
"Aerobic (Risk)" [latent,pos="-1.237,-3.915"]
"Altered Gravity" [exposure,pos="-1.242,-1.448"]
"Astronaut Selection" [pos="-1.242,-2.613"]
"Cardiac Structure/Function" [pos="-1.239,-2.226"]
"Crew Capability" [pos="-1.236,-3.025"]
"Crew Health and Performance System" [pos="-1.240,-3.728"]
"Detect CV Events" [pos="-1.238,-2.468"]
"Detect Long Term Health Outcomes" [pos="-1.236,-0.384"]
"Distance from Earth" [exposure,pos="-1.242,-4.223"]
"Endocrine Factors" [pos="-1.241,-1.952"]
"Environmental Conditions" [pos="-1.238,-0.082"]
"Flight Recertification" [outcome,pos="-1.235,-1.394"]
"Fluid Shifts" [pos="-1.241,-1.621"]
"Food and Nutrition, Immune, Sleep (Risks)" [latent,pos="-1.241,-0.594"]
"HSIA (Risk)" [latent,pos="-1.242,-3.207"]
"Hostile Closed Environment" [exposure,pos="-1.242,-0.026"]
"Individual Factors" [pos="-1.241,-2.441"]
"Individual Readiness" [pos="-1.237,-3.520"]
"Intravascular Volume" [pos="-1.240,-2.090"]
"Long Term Health Outcomes" [outcome,pos="-1.235,-0.944"]
"Loss of Crew Life" [outcome,pos="-1.235,-1.803"]
"Loss of Mission Objectives" [outcome,pos="-1.236,-3.619"]
"Loss of Mission" [outcome,pos="-1.235,-4.213"]
"Medical Illness" [pos="-1.238,-1.739"]
"Medical Monitoring Capability" [pos="-1.239,-3.566"]
"Medical Prevention Capability" [pos="-1.239,-3.123"]
"Medical Treatment Capability" [pos="-1.238,-3.936"]
"Organ Perfusion" [pos="-1.237,-1.739"]
"Orthostatic Intolerance Countermeasures" [pos="-1.240,-2.889"]
"Orthostatic Intolerance" [pos="-1.238,-0.708"]
"Oxidative Stress" [pos="-1.240,-1.196"]
"Pharm (Risk)" [latent,pos="-1.239,-4.059"]
"Pre-syncope/Syncope" [pos="-1.237,-2.478"]
"Suit Design" [pos="-1.241,-2.813"]
"Task Performance" [outcome,pos="-1.236,-2.673"]
"Tox (Risk)" [latent,pos="-1.238,-1.314"]
"Vascular Structure/Function" [pos="-1.239,-1.234"]
"Vehicle Design" [pos="-1.241,-3.910"]
Evacuation [outcome,pos="-1.236,-2.144"]
Exercise [pos="-1.241,-3.161"]
Inflammation [pos="-1.240,-0.559"]
Radiation [exposure,pos="-1.242,-0.969"]
Surveillance [pos="-1.237,0.102"]
"Aerobic (Risk)" -> "Individual Readiness"
"Altered Gravity" -> "Endocrine Factors"
"Altered Gravity" -> "Fluid Shifts"
"Altered Gravity" -> "Oxidative Stress"
"Altered Gravity" -> Inflammation
"Astronaut Selection" -> "Individual Factors"
"Cardiac Structure/Function" -> "Aerobic (Risk)"
"Cardiac Structure/Function" -> "Medical Illness"
"Cardiac Structure/Function" -> "Orthostatic Intolerance"
"Crew Capability" -> "Task Performance"
"Crew Health and Performance System" -> "Medical Monitoring Capability"
"Crew Health and Performance System" -> "Medical Prevention Capability"
"Crew Health and Performance System" -> "Medical Treatment Capability"
"Crew Health and Performance System" -> Exercise
"Detect CV Events" -> "Medical Treatment Capability"
"Distance from Earth" -> "Vehicle Design"
"Endocrine Factors" -> "Fluid Shifts"
"Endocrine Factors" -> "Orthostatic Intolerance"
"Environmental Conditions" -> "Orthostatic Intolerance"
"Fluid Shifts" -> "Cardiac Structure/Function"
"Fluid Shifts" -> "Intravascular Volume"
"Fluid Shifts" -> "Oxidative Stress"
"Fluid Shifts" -> "Vascular Structure/Function"
"Fluid Shifts" -> Inflammation
"Food and Nutrition, Immune, Sleep (Risks)" -> "Oxidative Stress"
"Food and Nutrition, Immune, Sleep (Risks)" -> Inflammation
"HSIA (Risk)" -> "Crew Health and Performance System"
"HSIA (Risk)" -> "Suit Design"
"HSIA (Risk)" -> "Vehicle Design"
"Hostile Closed Environment" -> "Orthostatic Intolerance"
"Individual Factors" -> "Cardiac Structure/Function"
"Individual Factors" -> "Endocrine Factors"
"Individual Factors" -> "Fluid Shifts"
"Individual Factors" -> "Oxidative Stress"
"Individual Factors" -> "Vascular Structure/Function"
"Individual Factors" -> Inflammation
"Individual Readiness" -> "Crew Capability"
"Intravascular Volume" -> "Cardiac Structure/Function"
"Intravascular Volume" -> "Orthostatic Intolerance"
"Intravascular Volume" -> "Vascular Structure/Function"
"Long Term Health Outcomes" -> "Detect Long Term Health Outcomes"
"Loss of Mission Objectives" -> "Loss of Mission"
"Medical Illness" -> "Detect CV Events"
"Medical Illness" -> "Flight Recertification"
"Medical Illness" -> "Long Term Health Outcomes"
"Medical Illness" -> "Organ Perfusion"
"Medical Monitoring Capability" -> "Detect CV Events"
"Medical Prevention Capability" -> "Intravascular Volume"
"Medical Prevention Capability" -> "Medical Illness"
"Medical Prevention Capability" -> "Orthostatic Intolerance Countermeasures"
"Medical Treatment Capability" -> "Organ Perfusion"
"Organ Perfusion" -> "Loss of Crew Life"
"Organ Perfusion" -> "Pre-syncope/Syncope"
"Organ Perfusion" -> Evacuation
"Orthostatic Intolerance Countermeasures" -> "Orthostatic Intolerance"
"Orthostatic Intolerance" -> "Organ Perfusion"
"Oxidative Stress" -> "Cardiac Structure/Function"
"Oxidative Stress" -> "Vascular Structure/Function"
"Oxidative Stress" -> Inflammation
"Pharm (Risk)" -> "Medical Prevention Capability"
"Pharm (Risk)" -> "Medical Treatment Capability"
"Pre-syncope/Syncope" -> "Individual Readiness"
"Suit Design" -> "Orthostatic Intolerance Countermeasures"
"Task Performance" -> "Loss of Mission Objectives"
"Tox (Risk)" -> "Medical Illness"
"Vascular Structure/Function" -> "Aerobic (Risk)"
"Vascular Structure/Function" -> "Medical Illness"
"Vascular Structure/Function" -> "Orthostatic Intolerance"
"Vehicle Design" -> "Crew Health and Performance System"
"Vehicle Design" -> "Orthostatic Intolerance Countermeasures"
Evacuation -> "Loss of Crew Life"
Evacuation -> "Loss of Mission Objectives"
Exercise -> "Cardiac Structure/Function"
Exercise -> "Intravascular Volume"
Exercise -> "Oxidative Stress"
Exercise -> "Vascular Structure/Function"
Exercise -> Inflammation
Inflammation -> "Cardiac Structure/Function"
Inflammation -> "Vascular Structure/Function"
Radiation -> "Oxidative Stress"
Radiation -> Inflammation
Surveillance -> "Detect Long Term Health Outcomes"
}