Study of the Effects of Spaceflight Factors on Bacteriophages (Bacteriophage) - 03.07.18
The Study of the Effects of Spaceflight Factors on Bacterophages (Bakteriofag) investigation examines the therapeutic, diagnostic, and genetic properties of bacteriophages to discover possible changes in the physical, chemical, morphological, and genetic properties of therapeutic and diagnostic bacteriophages exposed to microgravity. Science Results for Everyone
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OpNom:
Principal Investigator(s)
S. Yu. Pchelintsev, Biopreparat, Russia
V G. Popov, Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia
Co-Investigator(s)/Collaborator(s)
Information Pending
Developer(s)
Information Pending
Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
Sponsoring Organization
Information Pending
Research Benefits
Information Pending
ISS Expedition Duration
October 2009
- September 2010
Expeditions Assigned
21/22,23/24
Previous Missions
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Experiment Description
Research Overview
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Description
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Applications
Space Applications
During the long-term presence of crewmembers in space station conditions, human microflora infiltrates the structure, equipment, and materials which cause conditions similar to the development of hospital based infections. On Earth, the battle with these infections is fought using harsh disinfectants that cannot be used in spaceflight conditions. In these conditions, bacteriophage preparations turn out to be indispensable; the treatment with them may be similar to wet cleaning, and after inactivation of microorganisms, the bacteriophages themselves die. Such specific sterilizing preparations also help to eliminate dispersed microorganisms destroying materials and equipment. Therefore, during long-term autonomous spaceflight conditions, having such preparations on board the vehicle is promising.
Earth Applications
Bacteriophages are used to prevent and treat certain bacterial infections. Due to their specific lytic action on bacteria, they are an alternative to antibiotics. They are strictly specific, and live in the human body in the presence of specific bacterial flora, then due to the absence of a substrate, they die and the body self-cleans.
Operations
Operational Requirements and Protocols
Information Pending
Decadal Survey Recommendations
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^ back to topResults/More Information
Of the lyophilically dried bacteriophages exposed on the ISS one, Staphylococcus aureus bacteriophage exhibited increased lytic activity. Data indicated that in the lyophilically dried forms of bacteriophages exposed to space factors, the structure of particles was unchanged and the heads of the phage particles contain DNA. The biological properties of the bacteriophages (morphology of negative colonies, spectrum of lytic action, and stability under the influence of fluctuating pH levels) do not change relative to initial data. All studied bacteriophages retained their viability and biological activity after being in space for 3 months. However, it was noted that the concentration of bacteriophages was an order of magnitude lower than the initial concentration.
^ back to topRelated Websites
Energia - Science Research on the ISS Russian Segment
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