Characteristics of Pharmacological Responses (absorption, distribution and elimination of acetominophene) in Long Duration Space Flight (Pharma) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Objectives for Everyone
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Science Results for Everyone
Take two super-powered capsules and do not call me in the morning. In space, doses of acetaminophen are more powerful than on Earth. This research also showed that space-flight conditions do not disrupt liver function, making it unlikely that changes occur in the first-pass effect, a phenomenon by which organs such as the liver reduce the dose before a drug reaches its target. This study of the mechanism of drug absorption and elimination was also the first to compare the effectiveness of tablet versus capsule forms of acetaminophen. The data show that capsules are preferable to tablets for treatment in spaceflight.

The following content was provided by I B. Goncharov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
I B. Goncharov, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
March 2001 - December 2002; November 2002 - May 2003; April 2003 - October 2005

Expeditions Assigned
2,3,4,5,6,7,8,9,10,11

Previous Missions
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Experiment Description

Research Overview
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Description
An integrated study of distinctive features of the mechanism of distribution and elimination of pharmaceutical preparations under prolonged space flight conditions.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements and Protocols
Reflotron-4 Complexfor functional investigation of liver by blood count, Saliva-F Kit for sampling saliva from oral cavity.
Study of therapeutic efficiency of a medicinal preparation on a human organism exposed to space flight factors.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

For the first time during spaceflight, the bioavailability of a drug was studied. It was shown that after a single dose of the drug in spaceflight conditions, the relative biological availability of acetaminophen was significantly higher in the majority of flight test subjects than in baseline studies. Research on liver function after ingestion of acetaminophen showed that spaceflight conditions did not lead to disruption of liver function, therefore it was unlikely that a change in the first-pass effect, which occurs in the liver, would be the key point in the change observed in the pharmacokinetics of acetaminophen. It was also the first time a comparative study was performed on the pharmacokinetics of tablet versus capsule forms of acetaminophen. It was shown that the capsule form of acetaminophen was preferable to the tablet form when taken for treatment purposes in spaceflight.

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Results Publications

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image A Saliva F kit.
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image The Reflotron-4 equipment.
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