Study of Fluid and Electrolyte Metabolism and Hormonal Regulation of Fluid Volume in Spaceflight Conditions (Diurez (Diuresis)) (Diurez (Diuresis)) - 05.09.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Diurez gathers new data on the state of fluid and electrolyte metabolism and hormonal regulation of the body’s fluid volume in microgravity conditions and in the readaptation period after spaceflight. Analyses of bio samples (venous and capillary blood, and urine) help to characterize the final stage of fluid and electrolyte metabolism in microgravity.
Science Results for Everyone
Electrolytes (ie. sodium and potassium)affect the amount of water in our body fluids as well as muscle function and other important processes. This experiment evaluated how metabolism of electrolytes changes in microgravity. Data showed that younger crew members tend to have a lower body mass index and more muscular crew members show an increased blood concentration of potassium. Data also showed changes in hormones involved in signaling in the central nervous system. Such changes could affect blood pressure, cardiac output, and balance in long-term flight. These factors will be useful in evaluating nutritional status and physical and mental activities of crewmembers during and after flight. 

The following content was provided by Irina M. Larina, and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)
Irina M. Larina, Institute for Biomedical Problems, Moscow, Russia

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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
August 2001 - December 2002; November 2002 - May 2003; April 2003 - April 2005

Expeditions Assigned

Previous Missions
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Experiment Description

Research Overview
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Space Applications
The results obtained from Diurez help to improve the medical support system for long-term spaceflight, including how work and rest schedules, medical monitoring, training, and postflight rehabilitation of crew members are organized.

Earth Applications
Diurez promotes the development of medicine to counteract space-induced metabolic changes, which may also be applied to related ailments on Earth.

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Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

Initial data showed that, during flight, the volume of morning fluid consumption decreased significantly, which could be caused by activity features of the work/rest routine. Data showed a close connection between the age and the BMI of crew members with other studied indicators. These factors must be considered when evaluating the nutritional status and the physical activities of the crew members.

In microgravity and postflight, a decrease was observed in the blood concentration of prolactin, which indirectly indicates an increase in dopaminergic (signaling) activity of the central nervous system. These effects must be considered when planning the level of postflight physical and mental activity of the crewmembers.

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Results Publications

    Morukov BV, Nichiporuk IA, Tret'yakov VS, Larina IM.  Biochemical Markers of Bone Tissue Metabolism in Cosmonauts After a Prolonged Spaceflight. Human Physiology. 2005; 31(6): 684-687. DOI: 10.1007/s10747-005-0115-z.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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