Fluid and Electrolyte Metabolism and Hormonal Regulaltion of Fluid Volume (Diurez (Diuresis)) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Information Pending
Science Results for Everyone
Electrolytes (ie. sodium and potassium)affect the amount of water in our body fluids as well as muscle function and other important processes. This experiment evaluated how metabolism of electrolytes changes in microgravity. Data showed that younger crew members tend to have a lower body mass index and more muscular crew members show an increased blood concentration of potassium. Data also showed changes in hormones involved in signaling in the central nervous system. Such changes could affect blood pressure, cardiac output, and balance in long-term flight. These factors will be useful in evaluating nutritional status and physical and mental activities of crewmembers during and after flight. 

The following content was provided by Irina M. Larina, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Irina M. Larina, Institute for Biomedical Problems, Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
August 2001 - December 2002; November 2002 - May 2003; April 2003 - April 2005

Expeditions Assigned
3,4,5,6,7,8,9,10

Previous Missions
Information Pending

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Experiment Description

Research Overview
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Description
Reception of new data on the water-salt metabolism status and hormonal control of volimia in zero-gravity conditions and during post-flight readaptation period.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements and Protocols
Plasma-03 centrifuge to separate blood into plasma and serum, Plasma-03 set of accessories for sampling, Gematokrit Kit to take blood samples and separate plasma from erythrocytes defining hematocrit number, Reflotron-4 Kit capillary blood count for hemoglobin, creatinine and urea, KV-03 Container, Plasma-03 Kit for taking, processing and storage of venous blood and urine, M-Priemniki Kit to study water-salt metabolism, Cryogem-03 refrigerator to freeze blood samples.
Study of the dependence between renal elimination activity and its hormonal control. Study of the balance of liquid and main electrolytes.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Initial data showed that, during flight, the volume of morning fluid consumption decreased significantly, which could be caused by activity features of the work/rest routine. Data showed a close connection between the age and the BMI of crew members with other studied indicators. These factors must be considered when evaluating the nutritional status and the physical activities of the crew members.

In microgravity and postflight, a decrease was observed in the blood concentration of prolactin, which indirectly indicates an increase in dopaminergic (signaling) activity of the central nervous system. These effects must be considered when planning the level of postflight physical and mental activity of the crewmembers.

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Results Publications

    Morukov BV, Nichiporuk IA, Tret'yakov VS, Larina IM.  Biochemical Markers of Bone Tissue Metabolism in Cosmonauts After a Prolonged Spaceflight. Human Physiology. 2005; 31(6): 684-687. DOI: 10.1007/s10747-005-0115-z.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Plasma-03 kit.
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