Revealing Genotypical Characteristics, Defining Individual Differences in Resistance of Biological Organisms to Factors of Long Duration Space Flight (Poligen (Polygene)) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

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The following content was provided by O. M. Larina, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
O. M. Larina, Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
November 2000 - March 2001; April 2003 - October 2003; April 2009 - September 2010; March 2011 - September 2012; March 2013 - September 2013; September 2014 - September 2015

Expeditions Assigned
1,7,19/20,21/22,23/24,27/28,29/30,31/32,35/36,41/42,43/44

Previous Missions
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Experiment Description

Research Overview
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Description
Defining genetic criteria for revealing living organisms with a maximum possible resistance to extreme conditions of a prolonged space flight.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements and Protocols
Drozofila kit containing object under study (fruit fly, Drosophila melanogaser).
Identifying an integral structure of genotype of test objects - populations of fruit fly Drosophila melanogaser. Comparing the genetic characteristics obtained with the results of investigating fruit fly capability to endure space flights.

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Decadal Survey Recommendations

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Results/More Information

For the Poligen experiment on the ISS, the Drozofila-2 kit (figure-1) is used, with 2 containers for holding flies and feed. From the experiments, it was found that in some stages of the individual development of the insects, specifically in the stages of middle and late chrysalis, exposure to sub-optimal environmental conditions (environmental stress) during spaceflight and/or ground transportation from the landing site could induce an increase in the frequency of dominant lethal mutations in drosophila. The data obtained confirm the possibility of mutagenesis activation when exposed to unfavorable factors corresponding to actual spaceflight. In this context, in addition to ionizing radiation, exposure to microgravity, dynamic impacts, changes in the atmospheric composition, changes in temperature could affect mutation frequency. The results of the experiment also make it possible to hypothesize that one of the causes for contradicting data on the effect of spaceflight factors on the mutation process found in some literature could be a change in drosophila sensitivity to genotoxic factors occurring during individual development.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Drozofila kit.
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image One of the Drozofila containers.
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