Identifying the Genetic Features Determining Individual differences in the Resilience of Biological Objects to Long-term Spaceflight Factors Studies with the Fruit Fly Drosophila melanogaster (Poligen) (Poligen (Polygene)) - 03.14.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

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The dentifying the Genetic Features Determining Individual differences in the Resilience of Biological Objects to Long-term Spaceflight Factors Studies with the Fruit Fly Drosophila melanogaster (Poligen) experiment studies the links between parameters of the capability of D. melanogaster populations to adapt to spaceflight and their genetic structure. At the present time, the causes of the individual sensitivity to genetic mutations and inducing factors during spaceflight have not been fully studied. The ability of an organism to withstand mutagenic factors depends on the features of its genotype, in particular the systems of genes controlling processes of DNA repair.
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The following content was provided by O. M. Larina, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
O. M. Larina, Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
November 2000 - March 2001; April 2003 - October 2003; April 2009 - September 2010; March 2011 - September 2012; March 2013 - September 2013; September 2014 - September 2015

Expeditions Assigned
1,7,19/20,21/22,23/24,27/28,29/30,31/32,35/36,41/42,43/44

Previous Missions
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Experiment Description

Research Overview
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Description
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Applications

Space Applications
As a result of the experiment, data are expected to be obtained on genes and gene systems, the functional activity of protein products whose expression influences the resilience of eukaryotic organisms to mutational changes when exposed to a range of spaceflight factors. Determining the individual genotypes of these genes could be used to predict the risk of mutations occurring in biological organisms, including humans, in near-Earth spaceflight. The results of the studies could potentially be used to assess gene mutation vulnerability of spaceflight candidates.

Earth Applications
A possible promising use of the space experiment results on Earth is analyzing the individual genotypes in order to identify genetic indications of resilience to mutational disruptions caused by stress factors and unfavorable environmental conditions.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

For the Poligen experiment on the ISS, the Drozofila-2 kit (figure-1) is used, with 2 containers for holding flies and feed. From the experiments, it was found that in some stages of the individual development of the insects, specifically in the stages of middle and late chrysalis, exposure to sub-optimal environmental conditions (environmental stress) during spaceflight and/or ground transportation from the landing site could induce an increase in the frequency of dominant lethal mutations in drosophila. The data obtained confirm the possibility of mutagenesis activation when exposed to unfavorable factors corresponding to actual spaceflight. In this context, in addition to ionizing radiation, exposure to microgravity, dynamic impacts, changes in the atmospheric composition, changes in temperature could affect mutation frequency. The results of the experiment also make it possible to hypothesize that one of the causes for contradicting data on the effect of spaceflight factors on the mutation process found in some literature could be a change in drosophila sensitivity to genotoxic factors occurring during individual development.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Drozofila kit.
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image One of the Drozofila containers.
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