Research and Development of a Self-Contained Reactor of the Shielded Type For Production of Biomass of Microorganisms and Biologically Active Substances (Bioemulsia-Bioreactor-1) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Bioemulsia (Bioemulsion) uses a thermally controlled bioreactor to produce a biomass of microorganisms.
Science Results for Everyone
Information Pending

The following content was provided by E. N. Sventitski, G. Y. Scherbakov, M.D., Tatiana K. Krasheninnikova, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
E. N. Sventitski, Biopreparat, Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia
Tatiana K. Krasheninnikova, Institute for Applied Biochemistry and Machine Building (Biohimmash), Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
October 2004 - April 2005; October 2005 - October 2008

Expeditions Assigned
10,12,13,14,15,16,17

Previous Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
Development of moderate-stage technologies to produce biomass of microorganisms and biologically active substances (BAS) to provide highly efficient ecologically safe production of bacterial, fermental and medicinal preparations. Test of the autonomous reactor of the closed type onboard the ISS.

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Applications

Space Applications
Information Pending

Earth Applications
Information Pending

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Operations

Operational Requirements and Protocols
thermally controlled container-body with the actuator control unit, Thermally insulated returned container Biokont-T, Replaceable bioreactor in ziplock-bag.
Test of the autonomous reactor of the closed type onboard the ISS.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

The distinction of Bioemulsiya space experiments series performed in 2014 as compared to the earlier experiments is in the using dry powder as the culture material obtained from peroral Vitaflor pills produced on the industrial production line at the State Research Institute of High-Purity Biopharmaceuticals. The experiment used the pills of Series #01-0613 produced in June 2013 and stored at room temperature until the experiment (April 2014). Based on the results obtained, several conclusions can be drawn.

During a full culturing cycle on the ISS of the Vitaflor® symbiotic complex of acidophilus bacteria in Rekomb-K hybridizers, a fermented milk product was obtained with a high titration of L. acidophilus (at least 3.6×108 CFU/mL). Probiotic lactobacilli in the flight and ground-produced samples maintained a high probiotic potential for the entire observation period (52 days). Lactobacillus cells in the flight samples were in a physiologically active state and were of typical size (length) and morphology. The structures of lactobacillus populations in the flight samples were represented by two strains; the flight samples experienced an increase in the fraction of strain D #75, producing extracellular polysaccharides (mucosal strain). Lactobacilli in the flight samples manifested clear antagonism to the opportunistic pathogenic bacteria S. aureus and К. pneumoniae, and were resistant to the counter-antagonism of opportunistic pathogenic bacteria and antibiotics (tetracycline, ampicillin, gentamicin). Lactobacilli in the flight and ground fermented milk products had a long-term shelf stability at low temperatures (+6°С).

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image The container body. Image courtesy of FSA.
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image Bioemulsa reactor. Image courtesy of FSA.
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image NASA Image: ISS027E022456 - Expedition 27 flight engineer and cosmonaut Alexander Samokutyaev conducts Bioemulsiya (Bioemulsion) experiment operations in the Russian Glavboks-S (Glovebox).
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