Study of the Condition of Periodontal Tissues in Space Flight (Parodont (Parodentium)) (Parodont (Parodentium)) - 05.09.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Significant changes in the local immunity and microbial (bacteria) system of the periodontium (tissue near the teeth) qualify as risk factors for the development of inflammatory diseases of the periodontium and possibly are one of the specific manifestations of the postflight readaptation state of crew members’ bodies. Paradont studies the condition of local immunity and microflora in the mouth of crew members participating in missions on the International Space Station (ISS).
Science Results for Everyone
Will the tooth fairy visit you in space? This investigation determined that significant changes occur during spaceflight in the tissue around teeth, which can affect immune response and increase the risk of inflammation and disease. Crewmembers took samples of their saliva and from the surface of a tooth for laboratory analysis back on the ground, where researchers observed decreases in beneficial microflora – bacteria and other living organisms – and increases in harmful microflora. The results will be used to improve dental care to protect crewmembers, and people on Earth, against periodontal disease.

The following content was provided by Vyacheslav Constantinovich Ilyin, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Vyacheslav Constantinovich Ilyin, Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
November 2000 - December 2002; November 2002 - May 2003; April 2003 - October 2003

Expeditions Assigned
1,2,3,4,5,6,7

Previous Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
Information Pending

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Applications

Space Applications
A preventative probiotic product, a periodontal patch, is developed, in the form of a lyophilized substance as a strip containing lactobacilli immobilized on collagen. Results obtained from the study help researchers to conclude that the use of the periodontal patch is the best way of locally treating chronic generalized periodontitis in the flare-up stage.

Earth Applications
The studies make it possible to open new fields of research to monitor the condition of microflora in the mouth. A beneficial application kit is developed from the research, lactobacterin immobilized on a collagen sponge, and successfully underwent clinical testing (for the prevention of periodontitis).

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Operations

Operational Requirements and Protocols
Information Pending

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Laboratory analysis of the returned materials are performed on the ground and involved quantitative measurements of the concentration of opportunistic pathogenic microflora in the mouth. The Parodont experiment established that during spaceflight significant changes occurred in local immunity and microflora in the tissues that surround and support the teeth of crew members, which increased the risk factors for the development of inflammatory diseases of the dentomaxillofacial system in crew members. It was noted that after flight the beneficial microflora in crew members was reduced against the growth of harmful microflora. This phenomenon increased the likelihood of periodontal disease.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Saliva-A Parodont Kit.
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image Parodont Kit with test tubes.
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image Criogem-03 freezer.
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