Study of Vegetative Regulation of the Cardiorespiratory System in Weightlessness (Puls (Pulse)) (Puls (Pulse)) - 05.09.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
The cardiovascular system and respiration play a central role in the body's life support during changes in the environment. Establishment of ideal conditioning in the cardiorespiratory system depends on the regulatory mechanisms' ability to effectively control the interaction between the activity of the heart, vascular system, and respiratory apparatus. The Study of Vegetative Regulation of the Cardiorespiratory System in Weightlessness (Puls (Pulse)) obtains new scientific information to improve the understanding of the cardiorespiratory system's mechanisms for adapting to long-term spaceflight.
Science Results for Everyone
This investigation of microgravity’s effect on human cardiorespiratory systems showed that stress is an important factor. The body can maintain high performance for a time, but the resulting increased stress affects the cardiovascular system. Stress therefore needs to be monitored during flight as a risk factor for health issues. Researchers also discovered a direct link between an individual’s autonomic or involuntary regulation of heart and respiratory rate and adaptation to weightlessness, making it possible to predict how crew members will adapt during flight. Evaluation of changes in autonomic regulation will also be useful for medical monitoring, since those changes predict disruptions in the affected organs. 

The following content was provided by Roman M. Baevsky, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Roman M. Baevsky, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
June 2002 - December 2002; November 2002 - May 2003; April 2003 - September 2006

Expeditions Assigned
5,6,7,8,9,10,11,12,13

Previous Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
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Applications

Space Applications
For space medicine and for the practice of medical monitoring of crew members, it is important to establish patterns of cardiorespiratory interaction when the body is at various functional statuses, since, as is well known, disruptions to the regulation of physiological functions usually precede the development of dangerous disruptions to homeostasis. The scientific results obtained are used to improve the system for medically monitoring spaceflight crew members. In addition, the materials obtained are highly important for understanding individual particulars of the process of human adaptation to long-term weightlessness and open the door to creating a system for predicting the risk of developing health problems during flight.

Earth Applications
In the process of the examination, pneumo-tachograms, electrocardiograms, and photoplethysmograms are recorded, both at rest and during functional loadings. Using contemporary mathematical models of the regulation of the cardiovascular system, the following are evaluated: current functional status of the cardiovascular system, status of the sympathetic and parasympathetic component of cardiovascular system regulation, and the reserve capabilities of the cardiovascular and respiratory systems.

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Operations

Operational Requirements and Protocols
Information Pending

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Decadal Survey Recommendations

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Results/More Information

Ten ISS Russian crew members took part in the Puls experiment. The results of this scientific experiment showed that one important factor for evaluating the functional status of a crew member's body was the degree of stress on regulatory mechanisms at various stages of flight. In addition, it was demonstrated that long-term stress on the regulatory system leads to reduced functional reserves in the body. It was established that the tests performed in flight, involving set tempos for breathing and holding the breath at the inhalation and exhalation, were highly informative. One of the most important results of the experiments is the discovery of a direct link between the nature of adaptation to weightlessness and the individual's type of involuntary regulation.

The results of these studies were highly important not only theoretically, but also practically. First, knowledge of the individual type of involuntary regulation made possible the prediction of the nature of the crew member's adaptation reaction during flight. Second, evaluation of the status of autonomous regulation provided important information for the medical monitoring system, since disruptions to the involuntary balance that was developed in flight, shown as changes in the cardiac rhythm, significantly precede metabolic and structural disruptions in affected organs. Given an existing decline in self-regulation, the body is still capable, for a time, of maintaining high performance (while stress on the regulatory system is increasing). But then a break in adaptation may occur, in the form of various disruptions, including disruptions in the cardiovascular system. Thirdly, the increasing stress on the regulatory system during the flight required serious attention from the medical monitoring service, as a risk factor for the development of pathological changes.

The data obtained showed there was promise in further development of the proposed methods as applied to the task of improving the system for medical monitoring of crew members' health during long-term spaceflight.

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Results Publications

    Tank J, Chernikova AG, Baevsky RM.  Types of regulation and adaptation reactions in space flights. 5th Symposium of Autonomic Regulation, Lisbon, Portugal ; 2006 May 25-29

    Baevsky RM, Chernikova AG, Funtova II.  Assessment of Functional Status and Type of Regulation of the Circulatory System in Spaceflight Conditions Using Data for the Analysis of Cardiac Rhythm Variability. 7th Applied Science Conference on Diagnosis and Treatment of Disruptions to the Regulation of the Cardiovascular System. Moscow, Russia; 2005 Mar 23 310-318.

    Chernikova AG, Baevsky RM.  Mathematical Models of Functional Status Based on Analysis of Cardiac Rhythm Variability. All-Russian Symposium on the Variability of Cardiac Rhythm: Theoretical Aspects and Practical Application, Izhevsk, Russia; 2004 Sep

    Baevsky RM, Pashchenko AV, Funtova II, Chernikova AG.  Study of Vegetative Regulation of the Cardiovascular System in Long-Term Spaceflights on the International Space Station. Computerized Medicine Applied Science Conference. Kharkov, Ukraine; 2005 Jun 23-25

    Baevsky RM, Funtova II, Chernikova AG.  Principles of Creating a Medical Expert System for Evaluating Prenosological Statuses in Long-Term Spaceflights. Computerized Medicine Applied Science Conference. Kharkov, Ukraine; 2007 Sep 14-15

    Baevsky RM, Luchitskaya ES, Funtova II, Chernikova AG.  Study of the autonomic regulation of blood circulation during a long-term space flight. Human Physiology. 2013 October 11; 39(5): 486-495. DOI: 10.1134/S0362119713050046.

    Chernikova AG, Baevsky RM, Nikulina GA, Funtova II.  Analysis of Cardiac Rhythm Variability in Assessing Human Functional Status During Spaceflight. 19th Congress of the I.P. Pavlov Physiological Society; 2004

    Pashchenko AV, Baevsky RM.  New method for orthostatic test evaluation based on heart rate variability. Proceedings of the European Study Group on Cardiovascular Oscillations. Jena, Germany; 2006 May 15-17 78-81.

    Baevsky RM, Baranov VM, Bogomolov VV.  Experiments "Pulse" and "Pneumocard" aboard the International Space Station. The prospects for development of an automated medical monitoring system. 54th International Astronautical Congress, Bremen, Germany; 2003 September 29 - October 3

    Baranov VM, Baevsky RM, Drescher J, Tank J.  Investigations of the cardiovascular and respiratory systems on board the international space station: experiments PULS and PNEUMOCARD. 53rd International Astronautical Congress, The World Space Congress, Houston, TX; 2002 October 10-19

    Baevsky RM, Baranov VM, Funtova II, Diedrich A, Pashenko AV, Chernikova AG, Drescher J, Jordan J, Tank J.  Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station. Journal of Applied Physiology. 2007 July; 103(1): 156-161. DOI: 10.1152/japplphysiol.00137.2007. PMID: 17446414.

    Tank J, Baevsky RM, Drescher J, Funtova II.  Impact of cardiovascular research on board the International Space Station on the design of new medical devices. 2nd European Medical and Biological Engineering Conference (EMBEC). Vienna, Austria.; 2002 Dec 4-8

    Baevsky RM, Funtova II.  Analysis of Cardiac Rhythm Variability in Experiments on Board the International Space Station. All-Russian Symposium on the Variability of Cardiac Rhythm: Theoretical Aspects and Practical Application, Izhevsk, Russia; 2003 Nov

    Baevsky RM.  Theoretical and Applied Aspects of Controlling Adaptive Processes in Long-Term Spaceflight Conditions. The Body and Environment: Adaptation to Extreme Conditions. Moscow, Russia; 2003 24-26.

    Chernikova AG.  Mathematical Modeling of the Space of Functional Statuses Using Data from the Analysis of Cardiac Rhythm Variability. The Body and Environment: Adaptation to Extreme Conditions. Moscow, Russia; 2003 374-376.

    Baevsky RM, Baranov VM, Chernikova AG, Funtova II, Pashchenko AV, Tank J.  Heart rate variability as indicator of cardioregulatory system. Experiment result of ISS. Proceedings of the European Study Group on Cardiovascular Oscillations. Jena, Germany; 2006 May 15-17 74-77.

    Baranov VM, Baevsky RM, Pashchenko AV, Funtova II, Chernikova AG, Drescher J, Tank J.  Autonomous regulation of cardiovascular system in cosmonauts and prospects of researches on ISS. 57th International Astronautical Congress, Valencia, Spain; 2006 Oct 2-6

    Baevsky RM, Chernikova AG.  Heart rate variability analysis in evaluation of functional state in humans during long-term space flight. 14th Man in Space Symposium. Banff, Alberta, Canada; 2003 May

    Baevsky RM, Okhritsky AA, Pashchenko AV, Prilutsky DA, Funtova II.  Medical polygraph software for scientific research. Meditsinskaia Tekhnika (Biomedical Engineering). 2007; 1: 19-24.

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Ground Based Results Publications

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ISS Patents

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Related Publications

    Baevsky RM, Bersenev YY, Drescher J.  Computer Systems for Studying Circulation and Respiration on Board the International Space Station. Materials of the 12th Conference on Space Biology and Aerospace Medicine; 2002 38-39.

    Tank J, Baevsky RM, Berseneva AP.  –†rospects for development of novel research apparatuses for the international Space Station based on the experience of clinical and physiological investigations of the circulation regulating mechanisms. Symposium on the Achievements of Space Medicine in the Practice of Health Care and Industry. Berlin, Germany; 2001 164-176.

    Baevsky RM.  A System for Evaluating and Predicting the State of Health of Cosmonauts, and Prospects for its Development. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2001; 2: 36-45.

    Baevsky RM, Chernikova AG.  On the Problem of Physiological Norms: a Mathematical Model of Functional Status Based on Analysis of Variability of cardiac Rhythm. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2002; 5: 34-37.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image The Pulse Kit.
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