Studying the Impact of Various Spaceflight Factors on the Process of Regeneration in Terms of Morphological and Electro-Physiological Indicators (Regeneratsia-Planariya (Regeneration-Girardia)) (Regeneratsia-Planaria (Regeneration-Girardia)) - 03.14.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
The Studying the Impact of Various Spaceflight Factors on the Process of Regeneration in Biological Objects in Terms of Morphological and Electro-Physiological Indicators (Regeneratsiya-1) investigation uses the fresh water planarian as a model organism to study the affects of microgravity on regeneration. Understanding the importance of the force of gravity in different life processes in terrestrial organisms is a paradigm of space biology
Science Results for Everyone
Information Pending

The following content was provided by G. I. Gorgiladze, Ph.D., Vladimir Nikolaevich Sychev, Ph.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
G. I. Gorgiladze, Ph.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia
Vladimir Nikolaevich Sychev, Ph.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
April 2005 - October 2007; April 2008 - October 2008

Expeditions Assigned
11,12,13,14,15,17

Previous Missions
Information Pending

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Experiment Description

Research Overview
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Description
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Applications

Space Applications
In the experiment, new knowledge was obtained on the possibility for organism development in a sensory field in the absence of gravitation. The results obtained could be used by experts working in the field of developmental biology, and to develop and conduct lecture series in the relevant disciplines for students at university biology faculties.

Earth Applications
An increase in manned spaceflight duration, increase in the volume of work, and complication of operator tasks increase the risk of accidents and various types of injuries requiring surgical intervention in crewmembers. Because of this, information on the regeneration of damaged organs and tissues in animals and the anomalies occurring in a number of cases in the regenerated formations could be useful to refine the strategies of medical support during long-term manned spaceflight.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

In flights lasting 11-14 days (ISS-13, ISS-14, and ISS-17), it was shown that planarians retain a high regenerative capacity. In specimens in flight, like in the control on Earth, the restoration of missing body parts was noted.

From this, it was concluded that the absence of gravity is not a limiting factor for regeneration mechanisms. In addition, in a number of cases anomalies were identified in the flight regenerated specimens: planarians that regenerated from the longitudinal half of the body were noticeably curved compared to controls. The need to identify the possible causes of this phenomenon led to studies with longer exposure to spaceflight factors.

In the post-flight examination of capsule contents, in all the planarian specimens the appearance of missing body parts was established: in the right halves the missing left part regenerated; in the left halves, the right part. This same picture was observed in the cut halves of the torso during planarian regeneration. In each half of the torso, the anterior part of the body also regenerated. In the majority of cases, the regenerated planarians’ bodies curved to the right or the left by 30-90°. They would swim in circles, typically in the direction of the curve of the body.

In the first two runs of the experiment on station, data were obtained that were similar to previous data on the ISS with exposure three times shorter than exposure in the indicated flights. The background radiation recorded in the area of the planarian containers was approximately 120 higher than that in Moscow. This could be one of the causes of the anomalous development of the regenerated specimens, which requires further study.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery