Effect of Weightlessness on Processes of Regeneration by Electrophysiological and Morphological Factors (Regeneratsia-Planaria (Regeneration-Girardia)) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Regeneratsiya (Regeneration) grew planarian worms on microgravity.
Science Results for Everyone
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The following content was provided by G. I. Gorgiladze, Ph.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)
G. I. Gorgiladze, Ph.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
April 2005 - October 2007; April 2008 - October 2008

Expeditions Assigned

Previous Missions
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Experiment Description

Research Overview
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Assessment of zero-gravity impact on the structural and functional regeneration of the damaged organs and tissues of the animals involved in the experiment.

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Space Applications
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Earth Applications
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Operational Requirements and Protocols
Planaria incubators, ART Pouch.
Divide animals and record regeneration results.

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Decadal Survey Recommendations

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Results/More Information

In flights lasting 11-14 days (ISS-13, ISS-14, and ISS-17), it was shown that planarians retain a high regenerative capacity. In specimens in flight, like in the control on Earth, the restoration of missing body parts was noted.

From this, it was concluded that the absence of gravity is not a limiting factor for regeneration mechanisms. In addition, in a number of cases anomalies were identified in the flight regenerated specimens: planarians that regenerated from the longitudinal half of the body were noticeably curved compared to controls. The need to identify the possible causes of this phenomenon led to studies with longer exposure to spaceflight factors.

In the post-flight examination of capsule contents, in all the planarian specimens the appearance of missing body parts was established: in the right halves the missing left part regenerated; in the left halves, the right part. This same picture was observed in the cut halves of the torso during planarian regeneration. In each half of the torso, the anterior part of the body also regenerated. In the majority of cases, the regenerated planarians’ bodies curved to the right or the left by 30-90°. They would swim in circles, typically in the direction of the curve of the body.

In the first two runs of the experiment on station, data were obtained that were similar to previous data on the ISS with exposure three times shorter than exposure in the indicated flights. The background radiation recorded in the area of the planarian containers was approximately 120 higher than that in Moscow. This could be one of the causes of the anomalous development of the regenerated specimens, which requires further study.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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