Determination of Intracellular and Extracellular Fluid Volume in Humans in Space Flight (Sprut-MBI (Octopus-MBI)) - 10.25.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Objectives for Everyone
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Science Results for Everyone
The incredible shrinking astronaut. This investigation, one of several efforts to understand hydration and blood pressure adaptation in microgravity, highlighted the importance of gravity to the body’s water-electrolyte balance. A non-invasive device developed for the study allowed repeat, real-time measurements of hydration status during space flight. All subjects showed uniform loss of body fluids during long-term flight, with maximum loss immediately after return to Earth. Decrease in body fluids and related changes in body composition cause loss of muscle mass as well.  One week post-flight, data showed signs of recovering pre-flight hydration status and body mass.

The following content was provided by V B. Noskov, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
V B. Noskov, Institute for Biomedical Problems, Moscow, Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
June 2002 - December 2002; April 2003 - April 2006

Expeditions Assigned
5,7,8,9,10,11,12

Previous Missions
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Experiment Description

Research Overview
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Description
Investigation of a state of human liquid media, assessment of adaptation mechanisms and prevention of unfavorable impact of zero-gravity on the hydration status and post-flight orthostatic tolerance.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements and Protocols
Sprut-K Kit to determine different human liquid volumes by measuring the impedance of the body and its segments, Body mass meter with a range from 50 kg to 100 kg with an accuracy of 0.25 kg, Hematokrit microcentrifuge to separate plasma from erythrocytes, laptop and power supply unit.
Determination of volumes of intracellular and intercellular liquid, body's total liquid, circulating blood and relation between cellular and liquid blood component.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Results of SPRUT-MBI showed that the gravitation factor played the most important role in reaching another level of water-electrolyte homeostasis. The use of a non-invasive, spaceflight-compatible method of bioimpedancemetry for the first time in the world’s space programs made it possible to evaluate the hydration status of the human body directly during long-term spaceflight. Use of the Sprut-K onboard impedancemeter allowed the first repeat measurements in real time of the main fluid systems in 12 cosmonauts during 6-month orbital flights and the diagnosis of the development of dehydration of the body. Analysis of the obtained results showed that all 12 cosmonauts exhibited hydration decrease, and the range of individual changes during flight was quite narrow: from 5 to 10% for various fluid systems. The results showed the uniform loss of fluid from various fluid systems in the body during long-term spaceflight.

The maximum values for the shortage of fluids were noted immediately after the cosmonauts returned to Earth, which spoke to the particular intensity of the effects that the final phase of flight and landing have on water-electrolyte exchange. The development in weightlessness of hypohydration was discovered, expressed as a uniform decrease in fluid spaces, and characteristic changes in body composition. Moreover, the changes in and tempo of the reduction of fluid volumes, as well as the fat and muscle mass of the body, were closely comparable in character and magnitude. The majority of cosmonauts studied showed, despite individual variations, a clear reduction in the level of hydration during long-term exposure to weightlessness accompanied by a simultaneous loss of muscle mass. One week after flight completion, all parameters being studied showed a clear trend towards restoration of preflight hydration status and body mass.

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Results Publications

    Noskov VB, Nichiporuk IA.  Changes in the volume of the fluid spaces in the body of a cosmonaut during long-term spaceflight. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 2004; 90(8): 76.

    Noskov VB, Nichiporuk IA, Grigoriev AI.  Dynamics of the Body Liquids and Composition in Long-duration Space Flight (Bioimpedance Analysis). Human Physiology. 2011 December 22; 37(7): 821-825. DOI: 10.1134/S0362119711070231. PMID: 17902350.

    Noskov VB, Kotov AN, Morukov BV, Nichiporuk IA, Shargin YG.  Bioimpedance Analysis of Fluids and Body Composition Under the Conditions of Short-term Space Flight or Hypokinesia. Human Physiology. 2006 October; 32(5): 622-625. DOI: 10.1134/S0362119706050197. [Also: V.B. Noskov, A.N. Kotov, B.V. Morukov, I.A. Nichiporuk, Yu.G. Shargin, "Bioimpedance Analysis of Fluids and Body Composition During Sort-Term Spaceflights and Hypokinesia," Fiziologiya Cheloveka, 2006, Vol. 32, No. 5, pp. 136–139.]

    Noskov VB, Nichiporuk IA, Grigoriev AI.  Changes in fluid media and body composition during long-term spaceflight (bioimpedance analysis). Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2007; 41(3): 3-7.

    Noskov VB, Nikolaev DV, Tuikin SA, Kozharinov VI, Grachev VA.  A Portable Impedance Meter for Monitoring Liquid Compartments of the Human Body Under Space Flight Conditions. Meditsinskaia Tekhnika (Biomedical Engineering). 2007 March; 41(2): 94-96. DOI: 10.1007/s10527-007-0020-7.

    Noskov VB, Kotov AN.  Impedancemetric research of hydration status and body composition during antiorthostatic . Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2005; 39(4): 41-45.

    Noskov VB, Nichiporuk IA, Morukov BV, Malenchenko YI.  Study of the state of human bodily fluids during long-term spaceflight. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2005; 39(1): 27-31.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Sprut-MBI Kit.
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