Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity (Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity) - 09.13.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity tests a medically implantable glucose biosensor. Microgravity allows a simpler test environment to monitor the role of diffusion in glucose transport, which potentially improves the accuracy of the sensor. The findings may lead to a more reliable product for day-to-day diabetes management, overall benefitting the diabetic community.
Science Results for Everyone
Information Pending

The following content was provided by Michail Kastellorizios, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Michail Kastellorizios, Biorasis, Mansfield, CT, United States

Co-Investigator(s)/Collaborator(s)
Antonio Costa, Biorasis, Mansfield, CT, United States

Developer(s)
Space Tango, Inc., Lexington, KY, United States

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
National Laboratory (NL)

Research Benefits
Earth Benefits, Scientific Discovery

ISS Expedition Duration
September 2017 - February 2018

Expeditions Assigned
53/54

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • The GlucowizzardTM is a revolutionary, miniaturized (0.5 mm by 0.5 mm by 5 mm) device that reads glucose levels and transmits the information to any personal digital accessory such as a smartphone or personal computer.
  • The Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity investigation is expected to show improvement to the accuracy of medically implantable glucose biosensors for use primarily in day-to-day diabetes management.
  • Slow glucose transport from the capillary to the sensing site of the biosensor creates response delays that reach up to 20 minutes.
  • Microgravity allows for a simpler test environment to monitor the role of diffusion in glucose transport and potentially improve the accuracy of the sensor, with an aim to provide a more reliable product for the diabetic community.

Description
Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity tests a device called the Glucowizzard™, a holistic technology that alleviates all the major concerns of current continuous glucose monitoring devices. Aspects of the Glucowizzard™ include: extreme miniaturization for needle-based device implantation; drug-delivery coatings for complete suppression of foreign body responses upon implantation; a robust sensing element designed for highly accurate glucose levels; and a long-life time (minimum of three months). In addition, the bioanalyte platform (software that interprets results) is capable of simultaneous monitoring of more than one metabolite, including but not limited to, glucose, lactate, oxygen, carbon dioxide, and glutamate. The goal of the investigation is to improve the accuracy of medically implantable glucose biosensors for use, primarily in day-to-day diabetes management. Microgravity allows for a simpler test environment to monitor the role of diffusion in glucose transport and potentially improve the accuracy of the sensor. The microgravity environment is necessary to isolate the capillary action in the glucose diffusion factor. When compared to unit gravity experimental data post-launch, deconvolution of concentration gradient and capillary action contribution to glucose diffusion and resulting biosensor performance may be quantified.

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Applications

Space Applications
The investigation works upon on-going capillary action research, a field that needs thorough understanding for current and future space exploration.

Earth Applications
The successful evaluation of a medically implantable glucose biosensor in microgravity increases the effectiveness and reliability of minimally invasive glucose monitoring solutions. The potential for a more reliable glucose-monitoring product benefits diabetics worldwide.

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Operations

Operational Requirements and Protocols
The science is contained in a 2U CubeLab attached to Payload Card-5 for soft-stow ascent; it is to operate in the TangoLab locker and be soft-stow returned. The crew members install the payload card into the TangoLab locker, where autonomous operations occur and then they remove and stow the hardware for return. The Payload Card is returned on the same vehicle and turned over to the Space Tango/principal investigator (PI) team upon early return.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Related Websites
Space Tango

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Imagery