The Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity (Space Tango Payload Card Glucose Test 1 and 2) - 12.06.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity (Space Tango Payload Card Glucose Test 1 and 2) evaluates the accuracy of a medically implantable glucose biosensor, Glucowizzard, for day-to-day diabetes management. Glucose transport to the sensing site of a biosensor can take up to 20 minutes, a delay that complicates achieving tight glycemic control, and can lead to serious complications for diabetics. Microgravity makes it possible to isolate and monitor the glucose diffusion factor, which could lead to improvements in the accuracy of the sensor.
Science Results for Everyone
Information Pending

The following content was provided by Michail Kastellorizios, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Michail Kastellorizios, Biorasis, Mansfield, CT, United States

Co-Investigator(s)/Collaborator(s)
Allen Legassey, Biorasis, Inc, Storrs, CT, United States

Developer(s)
Space Tango, Inc., Lexington, KY, United States

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
National Laboratory (NL)

Research Benefits
Earth Benefits, Scientific Discovery

ISS Expedition Duration
April 2017 - September 2017

Expeditions Assigned
51/52

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • The Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity (Space Tango Payload Card Glucose Test 1 and 2) evaluates a revolutionary, miniaturized (0.5 × 0.5 × 5mm) device, called the Glucowizzard, that reads glucose levels in blood and transmits the information to any personal digital accessory, such as a smartphone or personal computer.

Description

The Deconvolution of Biosensor Glucose Diffusion Contributions in Microgravity (Space Tango Payload Card Glucose Test 1 and 2) focuses on the evaluation of the Gluccowizzard, a miniature device that can read glucose levels in blood, and transmits that information to any personal digital accessory. The Gluccowizzard technology is holistic, and alleviates all the major concerns of current continuous glucose monitoring devices including extreme miniaturization for needle-based device implantation; drug-delivery coatings for complete suppression of foreign body response upon implantation; robust sensing element design for highly accurate glucose levels; and long lifetime (minimum of three months).
 
In addition, the bio-analyte platform is capable of the simultaneous monitoring of more than one metabolite, including but not limited to glucose, lactate, oxygen, carbon dioxide, glutamate, etc.
 
The goal of the investigation is to improve the accuracy of medically implantable glucose biosensors for the primary use of day-to-day diabetes management. Slow glucose transport from the capillary to the sensing site of the biosensor creates response delays that can reach up to 20 minutes. This delay can be detrimental in achieving tight glycemic control, which has been linked to serious secondary diabetes complications. The microgravity environment allows for a more simplistic test environment to monitor the role of diffusion in glucose transport and potentially improve the accuracy of the sensor, which can provide a more reliable product for the diabetic community.
 
The microgravity environment is necessary to isolate the glucose diffusion factor from the capillary action. When compared to unit gravity experimental data post-launch, extrapolation of the concentration gradient, the capillary action contribution to glucose diffusion, and the resulting biosensor performance can be accurately quantified.

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Applications

Space Applications
The science is contained inside of a 2U CubeLab attached to Payload Card-2 for cold-stow ascent. The Space Tango Payload Card Glucose Test 1 and 2 operates in the TangoLab, and is returned in cold stowage. The crew installs the payload card into the TangoLab, where autonomous operations occur. At the end of operations, the crew removes, conditions, and stows the hardware for return to Earth. The Payload Card is returned on the same vehicle, and turned over to the Space Tango/Principal Investigator team during early return either in Houston, Texas or at the California airport.

Earth Applications

Successful evaluation of the Gluccowizzard in microgravity could lead to more effective and reliable, minimally invasive glucose monitoring for those with diabetes.

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Operations

Operational Requirements and Protocols
The science is contained inside of a 2U CubeLab attached to Payload Card-2 for cold-stow ascent. The Space Tango Payload Card Glucose Test 1 and 2 operates in the TangoLab, and is returned in cold stowage. The crew installs the payload card into the TangoLab, where autonomous operations occur. At the end of operations, the crew removes, conditions, and stows the hardware for return to Earth. The Payload Card is returned on the same vehicle, and turned over to the Space Tango/PI team during early return either in Houston, Texas or at the California airport.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Related Websites
Space Tango

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Imagery