Smooth Muscle Cell Culture (Space Tango Payload Card Smooth Muscle Cell Culture) - 11.29.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Objectives for Everyone
The Space Tango Payload Card Smooth Muscle Cell Culture (Smooth Muscle Cell Culture) flight experiment is led by the Craft Academy, in collaboration with its scientific partner, Morehead St. University, and its implementation partner Space Tango. Smooth Muscle Cell Culture evaluates the involuntary cell contractions of rat aortic smooth muscle cells that show expression and promoter activity of several highly restricted smooth muscle cell markers. The theory of contraction being proposed is that the remodeling of the actin cytoskeleton, might explain some of the unique properties of smooth muscle tissue, and could have an impact on the treatment of diseases.
Science Results for Everyone
Information Pending

The following content was provided by Michael Fultz, Ph.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Michael Fultz, Ph.D., Craft Academy at Moorehead State University, Moorehead, KY, United States

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Space Tango, Inc., Lexington, KY, United States

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
National Laboratory (NL)

Research Benefits
Earth Benefits, Scientific Discovery

ISS Expedition Duration
September 2016 - April 2017

Expeditions Assigned
49/50

Previous Missions
Information Pending

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Experiment Description

Research Overview
The Space Tango Payload Card Smooth Muscle Cell Culture (Smooth Muscle Cell Culture) flight experiment is a research/educational experiment whose purpose is to evaluate the involuntary cell contractions of aortic smooth muscle cells. Specifically, rat aorta smooth muscle cells, that show expression and promotor activity of several highly restricted smooth muscle cell markers, ate to be evaluated. The theory of contraction being proposed in this project is that the remodeling of the actin cytoskeleton, specifically that of a-action, is the contractile mechanism within smooth muscle cells, whereas the B-actin serves to maintain the cell's shape during contraction. If this contraction is observed in microgravity, then supporting, or contradictory, evidence of contractile cells and potential discoveries may be observed.

Description

The goals of the Space Tango Payload Card Smooth Muscle Cell Culture (Smooth Muscle Cell Culture) experiment involve:
  • Research on the ability of smooth muscle tissue to generate and maintain force with a reduction in energy expenditure.
  • The postulation that two actin cytoskeletal components within smooth muscle tissue, alpha-actin and beta-actin, reorganize during muscle contraction. This reorganization might explain some of the unique properties of smooth muscle tissue, and the research could have an impact on the treatment of diseases.
  • The effect of microgravity on the reorganization of the smooth muscle tissue components

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Applications

Space Applications
The Space Application for this investigation has yet to be identified.

Earth Applications
Results from this investigation could provide additional information regarding hypertension - where the pressure exerted on the artery walls is abnormally high. Findings could produce new understanding of the contractile mechanism that operates within these muscle cells to control blood pressure.

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Operations

Operational Requirements and Protocols
The science is contained in a 2U CubeLab attached to a Payload Card for soft-stow ascent, operates in the TangoLab-1, and is soft-stowed for return. The crew installs the Payload Card into the TangoLab-1, where autonomous operations occur, and then the crew removes and stows the hardware for return. The Payload Card is returned after the completion of the mission on the next available return vehicle (same vehicle as ascent is preferred) and turned over to the Space Tango/PI team at recovery.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Related Websites
Moorehead State University
Space Tango

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Imagery