Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity-2 (ROALD-2) - 03.23.17
Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity (ROALD2) investigates the function of endocannabinoids, substances produced within the body to activate cell membrane receptors, in the regulation of the immune processes and cell cycle under microgravity conditions. Science Results for Everyone
Information Pending Experiment Details
Natalia Battista, Ph.D., University of Teramo, Teramo, Italy
Mauro Maccarrone, Ph.D., M.S., University of Rome Biomedical Campus, Rome, Italy
Cinzia Rapino, University of Teramo, Teramo, Italy
M. Di Tommaso, University of Teramo, Teramo, Italy
Monica Bari, University of Rome Tor Vergata, Rome, Italy
Valeria Gasperi, University of Rome, Rome, Italy
Alessandro Finazzi-Agrò, University of Rome, Rome, Italy
Sponsoring Space Agency
European Space Agency (ESA)
ISS Expedition Duration
September 2011 - May 2012
ROALD2 expands on the objectives of the ROALD experiment flown on ISS in 2008 (BIO-4 mission), using similar experiment protocol.
- Anandamide (AEA) is the main representative of a family of polyunsaturated fatty acid amides and esters, called endocannabinoids.
- This project aims at investigating gene expression of the proteins involved in the metabolic control of AEA tone, in order to determine the role of this lipid in the regulation of immune processes and in the cell cycle under microgravity conditions.
- In fact, AEA is a signal for the cells to make a choice between life and death and it might be a contributor responsible for the immune deficit observed in space.
Operational Requirements and Protocols
Decadal Survey Recommendations
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Ground Based Results Publications
Battista N, Meloni MA, Bari M, Mastrangelo N, Galleri G, Rapino C, Dainese E, Finazzi-Agro A, Pippia P, Maccarrone M. 5-Lipoxygenase-dependent apoptosis of human lyphocytes in the International Space Station: data from the ROALD experiment. FASEB: Federation of American Societies for Experimental Biology Journal. 2012; 26(5): 1791-1798. DOI: 10.1096/fj.11-199406. PMID: 22253478.