Proof-of-Concept for Gene-RADAR® Predictive Pathogen Mutation Study (Nanobiosym Genes) - 11.22.16

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Proof-of-Concept for Gene-RADAR® Predictive Pathogen Mutation Study (Nanobiosym Genes) evaluates the feasibility of one day using this device from Nanobiosym® to identify bacterial mutations in space. The X Prize-winning device can accurately detect any disease that has a genetic fingerprint, in real time and at the point-of-care. Microgravity may accelerate the rate of bacterial mutations and this pilot investigation analyzes this process in two strains aboard the International Space Station, which may provide insight into how deadly bacteria become drug-resistant. The data can help refine models of drug resistance and support development of better medicines to counter it.
Science Results for Everyone
Information Pending

The following content was provided by Luis Zea, Ph.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom: Nanobiosym Genes

Principal Investigator(s)
Anita Goel, M.D., Ph.D., Nanobiosym, Inc., Cambridge, MA, United States

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
BioServe Space Technologies, University of Colorado, Boulder, CO, United States

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
National Laboratory (NL)

Research Benefits
Earth Benefits, Scientific Discovery, Space Exploration

ISS Expedition Duration
September 2016 - February 2017

Expeditions Assigned
49/50

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • Proof-of-Concept for Gene-RADAR® Predictive Pathogen Mutation Study (Nanobiosym Genes) is a proof-of-concept study to analyze how model organisms evolve in space, and use the empirical results to refine Nanobiosym®’s predictive mutation algorithms.
  • Nanobiosym® theorizes that computational algorithms for predicting bacterial mutations can be tested and evaluated by subjecting organisms, in this case, bacteria, to the microgravity environment provided by the International Space Station (ISS).
  • This experiment identifies the patterns of mutations in organisms grown in space compared to a gravity based control here on Earth.
  • This experiment provides data that can be applied to future predictive models for antibiotic resistant pathogen mutations, such as Methicillin-resistant Staphylococcus aureus (MRSA), which are of significant value to antibiotic drug development.
  • According to the Infectious Disease Society of America, Methicillin resistant Staphylococcus aureus (MRSA), kills more Americans every year than the combined total of emphysema, HIV/AIDS, Parkinson’s disease, and homicide.
  • This is one of many applications enabled by the Gene-RADAR® technology that can be used to accelerate development of new drugs, detect disease at the point-of-care, and serve as a mobile, low-cost solution to providing healthcare resources to underserved populations globally.

Description

The objective of the Proof-of-Concept for Gene-RADAR® Predictive Pathogen Mutation Study (Nanobiosym Genes) experiment is to perform a proof-of-concept study to evaluate how model organisms behave in space. Bacterial mutations are analyzed on two strains of Staphylococcus aureus and the data used to develop models that predict antibiotic-resistant pathogen mutations which are of significant value to antibiotic drug development. Due to the accelerated growth rate of bacteria in microgravity, the ISS is the ideal lab for this experiment. This experiment is integrated by BioServe Space Technologies at the University of Colorado, Boulder. The experiment is hosted in four BioCells Habitats, and makes use of BioServe’s Space Automated Bioproduct Lab (SABL) to culture the bacteria at 37°C.

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Applications

Space Applications

This experiment helps better predict mutation patterns in bacteria exposed to the microgravity environment of the space station. The Gene-RADAR® technology potentially could provide astronauts with real-time information about their health status and give them the ability to quickly diagnose diseases during spaceflight.

Earth Applications
Improved understanding of how bacteria mutate advances design of new antibiotics, which currently are not being developed fast enough to combat bacterial resistance. Real-time data collection and reporting tools such as this one also can be used to customize new medicines and make them more precise. In addition, the investigation contributes to development of a mobile, low-cost method to detect and diagnose disease in underserved populations on Earth and to help combat disease outbreaks.

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Operations

Operational Requirements and Protocols
The OmniTrays are loaded on four BioCell Habitats (P-HAB) and launched at 4°C. Once on orbit, the BioCell Habitats are transferred to SABL, which is set up at 4°C. For a controlled-start, SABL is commanded to increase the temperature to 37°C on the space station. To finish the incubation, SABL is commanded to 4°C. Samples are stored in SABL at 4°C until it is time for return. The BioCell Habitats return to Earth at 4°C.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Related Websites
Wall Street Journal
Nanobiosym Global Initiative Summit Website
BBC Feature Story: “The Genius Behind”
Forbes Op-ed
Nanobiosym, Inc.
Wired Magazine
Nanobiosym Gene-RADAR® X Prize Grand Prize Winner Video

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Imagery

image
Based on the frontier science of nanobiophysics, Nanobiosym’s Gene Radar® provides a portable solution to decentralizing healthcare and is the winner of the first ever XPRIZE awarded for healthcare. Image courtesy of Nanobiosym.

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