Role of the Edocannabinoid System in Pluripotent Human Stem Cell Reprogramming under Microgravity Conditions (SERISM) - 07.26.17

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Science Objectives for Everyone
Two previous missions documented the involvement of lipid signaling molecules called endocannabinoids in production of human immune cells. This Italian Space Agency investigation, Role of the Endocannabinoid System in Pluripotent Human Stem Cell Reprogramming under Microgravity Conditions (SERISM), evaluates the role of this system in bone metabolism changes seen in microgravity. Astronauts experience bone loss on extended missions and the identification of novel biomarkers that are involved during osteogenic differentiation in microgravity of an innovative stem cell model could contribute to ways of countering that loss.
Science Results for Everyone
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The following content was provided by Mauro Maccarrone, Ph.D., M.S., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom: Reprogramming Stem Cells

Principal Investigator(s)
Mauro Maccarrone, Ph.D., M.S., University of Rome Biomedical Campus, Rome, Italy

Information Pending

Kayser Italia Srl., Livorno, Italy

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
Italian Space Agency (ASI)

Research Benefits
Scientific Discovery

ISS Expedition Duration
April 2017 - September 2017; September 2017 - February 2018

Expeditions Assigned

Previous Missions
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Experiment Description

Research Overview

The goals of the Role of the Endocannabinoid System in Pluripotent Human Stem Cell Reprogramming under Microgravity Conditions (SERISM) investigation are:
  • Identification of biomarkers to be exploited in contrasting bone loss in space using an innovative stem cell model. Indeed, bone loss is a major thread to astronauts’ health during (extended) space missions.
  • Evaluation of the role of the endocannabinoid system in the alterations of bone metabolism in microgravity.
  • Identification of a novel therapeutic target for bone regeneration under microgravity conditions.

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Space Applications
This investigation, by helping to identify biomarkers involved in microgravity induced bone loss in an innovative stem cell model, contributes to development of therapies for bone regeneration in space.

Earth Applications
The abnormal physiology seen in otherwise healthy astronauts during their adaptation to space has many similarities with accelerated aging, including bone loss. On Earth, older people experience bone loss and fractures: both representing a serious health concern. This investigation could contribute to better treatment for this and other disabling conditions caused by aging.

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Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

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Related Websites

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