Nanotechnology Solutions against Oxidative Stress in Muscle Tissue during Long-term Microgravity Exposure (NANOROS) - 07.26.17

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Long-term exposure to microgravity causes oxidative stress in the body, which leads to severe changes in skeletal muscle anatomy and decreased muscle function. This investigation, Nanotechnology Solutions against Oxidative Stress in Muscle Tissue during Long-term Microgravity Exposure (NANOROS), examines the effectiveness of using cerium oxide nanoparticles to counter these muscle changes and the problems with function caused by those changes.
Science Results for Everyone
Information Pending

The following content was provided by Gianni Ciofani, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom: Oxidative Stress

Principal Investigator(s)
Gianni Ciofani, Italian Institute of Technology, Pisa, Italy

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
Italian Space Agency (ASI)

Research Benefits
Earth Benefits, Scientific Discovery

ISS Expedition Duration
April 2017 - September 2017; September 2017 - February 2018

Expeditions Assigned
51/52,53/54

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • As noticed when crew members return to Earth, long term exposures to microgravity conditions induce severe alterations in skeletal muscle both at an anatomical and a functional/postural level. Several studies on ground have recently shown how oxidative stress, due to the imbalance between production and elimination of oxygen reactive species (ROS), represents an important factor working to the detriment of cell activities. Oxidative stress induced by microgravity may be one of the main reasons for the harmful effects of the microgravity environment on skeletal muscle.
  • The aim of the Nanotechnology Solutions against Oxidative Stress in Muscle Tissue during Long-term Microgravity Exposure (NANOROS) investigation consists of the elaboration of countermeasures to microgravity-induced oxidative stress, relying on the use of nanotechnological antioxidants, such as cerium oxide nanoparticles (nanoceria). Currently studied as therapeutic solutions in biological systems, ceria nanoparticles, in fact, show electron defects in correspondence of oxygen atoms that represent reactive sites for ROS scavenging. The extreme versatility of nanoceria enables the use of their antioxidant properties, without the need for repetitive administrations.
  • The results achieved in this investigation can hopefully bring tremendous improvements not only in the quality of life during space missions, but even in the case of several pathologies due to oxidative stress on Earth.

Description
Information Pending

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Applications

Space Applications
Muscle loss during long-term spaceflight affects astronaut health, well-being, and performance. Possible countermeasures tested in this investigation can offer improved quality of life, and the ability to achieve mission objectives.

Earth Applications
Oxidative stress can also cause health issues in people on Earth. Countermeasures developed as a result of this investigation can offer improved quality of life to people with these conditions.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

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Related Websites

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Imagery