The Coenzyme Q10 (CoQ10) as an Antiapoptotic Countermeasure for Retinal Lesions Induced by Radiation and Microgravity on the ISS: Experiment on Cultured Retinal Cells (CORM) - 03.29.17

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Science Objectives for Everyone
The Coenzyme Q10 (CoQ10) as an Antiapoptotic Countermeasure for Retinal Lesions Induced by Radiation and Microgravity on the ISS: Experiment on Cultured Retinal Cells (CORM) investigates the use of Coenzyme Q10 to protect astronauts from retinal lesions caused by exposure to radiation and microgravity aboard the space station. The experiment uses cultured human retinal cells to examine the effects of radiation and microgravity and test potential protective effects of Coenzyme Q10. In addition to being an effective antioxidant, Coenzyme Q10 was shown to protect cells against excessive programmed cell death.
Science Results for Everyone
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The following content was provided by Matteo Lulli, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom: Retinal Lesion Study

Principal Investigator(s)
Matteo Lulli, Dep. of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy
Sergio Capaccioli, Dep. of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy

Co-Investigator(s)/Collaborator(s)
Monica Monici, ASA Campus Joint Laboratory, ASA Research Division - Dep. of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy
Alberto Magi, Dep. of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Stefano Cacchione, Dep. of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy

Developer(s)
Kayser Italia Srl., Livorno, Italy

Sponsoring Space Agency
National Aeronautics and Space Administration (NASA)

Sponsoring Organization
Italian Space Agency (ASI)

Research Benefits
Space Exploration, Earth Benefits

ISS Expedition Duration
April 2017 - September 2017

Expeditions Assigned
51/52

Previous Missions
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Experiment Description

Research Overview

  • Crew members living on board the International Space Station (ISS) are exposed to cosmic radiation and microgravity that are responsible for the induction of retinal lesions. Radiation and microgravity represent two of the greatest risks to the human body for long‐term exploration missions.
  • The Coenzyme Q10 (CoQ10) as an Antiapoptotic Countermeasure for Retinal Lesions Induced by Radiation and Microgravity on the ISS: Experiment on Cultured Retinal Cells (CORM) investigation studies the protective effects of Coenzyme Q10 on cultured human retinal cells exposed to radiation and microgravity inside the ISS.
  • Results obtained by CORM project are of fundamental importance for the development of pharmacological countermeasures for the prevention of retinal lesions that occur in the crew members during long‐term missions.

Description
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Applications

Space Applications
Human exposure to radiation and microgravity on long-term space missions causes significant health issues, including retinal lesions. CORM contributes to understanding of these lesions and advances development of drugs to help protect astronauts from them.

Earth Applications
People on Earth experience retinal lesions caused by conditions such as glaucoma and age‐related macular degeneration. This investigation helps determine whether Coenzyme Q10 can provide protection from or treat these conditions.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

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Related Websites

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Imagery