CYTOSKELETON (CYTOSKELETON) - 04.25.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
In vitro cultures of mammalian cells react specifically to microgravity, but there is no solid scientific evidence available about how and why. The Involvement of Rho family GTPases in gravity perception and reaction (Cytoskeleton) investigation attempts to acquire new information about the events that are happening inside a mammalian cell, with the working hypothesis that the microgravity environment affects the function of RhoGTPases and the cellular signaling that they control. RhoGTPases are signaling molecules residing under the Rho family of proteins, known to be involved as "molecular switches", in the control of cell proliferation, apoptosis (programmed cell death), gene expression (flow of genetic information from gene to protein), and cytoskeletal organization.
Science Results for Everyone
Information Pending

The following content was provided by Betty Nusgens, Prof., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom: Cytoskeleton

Principal Investigator(s)
Betty Nusgens, Prof., University of Liege, Sart-Tilman, Belgium

Co-Investigator(s)/Collaborator(s)
Alain Colige, University of Liege, Sart-Tilman, Belgium
Christophe Deroanne, University of Liege, Sart-Tilman, Belgium
Charles Lambert, University of Liege, Sart-Tillman, Belgium
Pierre Mineur, University of Liege, Sart-Tilman, Belgium
Thibaut Neutelings, University of Liege, Sart-Tilman, Belgium
Laurence Vico, Ph.D., LBTO INSERM, St. Etienne, France
Alain Guigandon, LBTO INSERM, France

Developer(s)
European Space Agency (ESA), Noordwijk, Netherlands

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
European Space Agency

Research Benefits
Earth Benefits, Scientific Discovery, Space Exploration

ISS Expedition Duration
March 2016 - September 2016

Expeditions Assigned
47/48

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • In microgravity, the internal machinery of the human cell is affected in a unique way. The Involvement of Rho family GTPases in gravity perception and reaction (Cytoskeleton) experiment is a cell biological study, aimed to determine the changing function of RhoGTPases when in vitro cell cultures are exposed to weightlessness. RhoGTPases are signaling molecules residing under the Rho family of proteins, known to be involved as "molecular switches" in the control of cell proliferation, apoptosis (programmed cell death), gene expression (flow of genetic information from gene to protein) and cytoskeletal organization.
  • The working hypothesis of Cytoskeleton is that microgravity affects the function of RhoGTPases and the cellular signaling that they control. Two cell types are tested: the fibroblast cell line WI-26, and the osteoblast cell line MG63. The two cells types are important for the body’s structure, with fibroblasts producing proteins, such as collagen which is the main component of connective tissue, and osteoblasts which are responsible for bone formation.
  • This research offers scientists a method to expand knowledge about cellular function in space and on Earth, which could feed into the development of future countermeasures to help maintain an optimal level of crew member health and performance, and could in turn find its way into clinical medical research.

Description
Information Pending

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Applications

Space Applications
This investigation helps to understand the way in which the human body responds to microgravity, which could feed into the development of future countermeasures to help maintain an optimal level of crew member health and performance.

Earth Applications
In microgravity, the internal machinery of the human cell is affected in a unique way that cannot be mimicked on ground. This research offers scientists a method to expand their knowledge about cellular function in space and on Earth. This new knowledge could, in turn, find its way into clinical medical research.

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Operations

Operational Requirements and Protocols
Information Pending

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Related Websites

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Imagery