Multi-omics analysis of human microbial-metabolic cross-talk in the space ecosystem (Multi-Omics) - 03.13.19

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Science Objectives for Everyone
The Multi-omics analysis of human microbial-metabolic cross-talk in the space ecosystem (Multi-Omics) investigation evaluates the impacts of space environment and prebiotics on astronauts’ immune function, by combining the data obtained from the measurements of changes in the gut microbiological composition, metabolites profiles, and the immune system.
Science Results for Everyone
Information Pending

The following content was provided by Hiroshi Ohno, M.D., Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Japan Aerospace and Exploration Agency (JAXA).
Experiment Details

OpNom: Multi-Omics

Principal Investigator(s)
Hiroshi Ohno, M.D., Ph.D., RIKEN Center for Integrative Medical Science, Yokohama, Japan

Masahira Hattori, Ph.D., Department of Computational Biology, Center for Omics and Bioinformatics (Director), Graduate School of Frontier Sciences, University of Tokyo, Chiba-ken, Japan
Jun Kikuchi, Ph.D., RIKEN Center for Sustainable Resource Science, Yokohama, Japan
Toshiko Ohta, Ph.D., Kagawa Nutrition University, Sakado, Japan
Kazuhiko Yamada, Ph.D., Kagawa Nutrition University, Sakado, Japan
Masaharu Kagawa, Ph.D., Kagawa Nutrition University, Sakado, Japan
Tamotsu Kato, Ph.D., JAXA Space Biomedical Research Office, Tsukuba, Japan
Brian E. Crucian, Ph.D., NASA Johnson Space Center, Houston, TX, United States

Japan Aerospace Exploration Agency, Tsukuba, Tsukuba, Japan

Sponsoring Space Agency
Japan Aerospace Exploration Agency (JAXA)

Sponsoring Organization
Japan Aerospace Exploration Agency

Research Benefits
Space Exploration, Earth Benefits, Scientific Discovery

ISS Expedition Duration
March 2015 - March 2016; March 2016 - October 2018

Expeditions Assigned

Previous Missions
Information Pending

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Experiment Description

Research Overview
It has been suggested that living on board the International Space Station (ISS) likely causes immune dysfunction in the crew members, but the precise underlying mechanisms for this dysfunction is not well understood. Recent studies have indicated that imbalance in gut microbiota composition, or dysbiosis, resulting from a variety of environmental stresses, could lead to various disease statuses including immune dysfunction. Therefore, metagenomic analysis of the gut microbiota from crew members should result in better understanding of the immune dysfunction of crew members on the ISS. The Multi-omics analysis of human microbial-metabolic cross-talk in the space ecosystem (Multi-Omics) could identify candidates of bacterial and/or metabolic biomarkers for immune dysfunction which could be utilized for the development of the method to amend observed dysbiosis.

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Space Applications
Biomarkers for immune dysfunction during the ISS flight could be useful for the health management of astronauts. Simple test kits for detection of the biomarkers are convenient for evaluating the immune dysfunction.

Earth Applications
Information on the effects and biomarkers could be applied to the fields of life sciences and technology.

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Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

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Related Websites

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With this proposal, researchers aim to understand the gut ecosystem, based on the host-gut microbiota interaction, of astronauts in space environment, especially focusing on immune dysfunction. Feces and/or saliva are collected non-invasively from astronauts and/or space-flown mice. These samples are subjected to metagenome, metabolome, gene expression profiling analysis to reveal the whole picture of changes in intestinal microbiota in response to space/ground environmental difference.

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