Effects of Spaceflight on endothelial function:  molecular and cellular characterization of interactions between genome transcription, DNA damage and induction of cell senescence (Endothelial Cells) - 11.22.16

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Human subjects and experimental animal models returning from space have shown muscle-skeletal and cardiovascular problems accredited to injury of the endothelium: the system of cells lining the inner surface of all blood vessels. The Effects of Spaceflight on endothelial function:  molecular and cellular characterization of interactions between genome transcription, DNA damage and induction of cell senescence (Endothelial Cells) investigation aims to understand the reaction of cultured endothelial cells to spaceflight, through cellular and genetic analysis.
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Information Pending

The following content was provided by Debora Angeloni, Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom:

Principal Investigator(s)
Debora Angeloni, Ph.D., Center for the Study of Physiology in Extreme Environments, Scuola Superiore Sant'Anna, , Pisa, Italy

Co-Investigator(s)/Collaborator(s)
Maria Grazia Andreassi, Ph.D., National Research Council - Institute of Clinical Physiology, Ospedale G. Pasquinucci,, Massa, Italy
Jeanette Maier, Ph.D., University of Milan, Milano, Italy
Francesca Scebba, Ph.D., Scuola Superiore Sant'Anna, Pisa, Italy
Enrico Tagliafico, Ph.D., Dept. of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Silvio Bicciato, Ph.D., Dept. of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy

Developer(s)
European Space Agency (ESA), Noordwijk, Netherlands

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
Information Pending

Research Benefits
Scientific Discovery, Earth Benefits, Space Exploration

ISS Expedition Duration
March 2015 - March 2016

Expeditions Assigned
43/44,45/46

Previous Missions
Information Pending

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Experiment Description

Research Overview

Endothelial cells cover the entire inner surface of the blood vessels, and play a crucial role in maintaining the functional integrity of the vascular wall. Functional properties of the endothelium include an active control of the various components of homeostasis, vascular tone and permeability, and medial smooth muscle cell growth. Indeed, endothelial dysfunctions promote several diseases, among which atherosclerosis, hypertension, diabetes, and thrombosis. Major alterations of endothelial behavior could also explain the high frequency of cardiovascular disease in the elderly. Human subjects and experimental animal models returning from space have shown muscle-skeletal and cardiovascular problems accredited to injury of the endothelium.
 
The goal of the Endothelial Cells investigation is to better understand the reaction of cultured endothelial cells to spaceflight. This is to be characterized in space-flown samples through analysis of different parameters including DNA damage, end of cell division (senescence), and variations of cell cycle combined with additional in-depth genetic analysis.
 
Because endothelial cells are responsible for the integrity of the vascular wall, a better understanding of the modulation of endothelial functions in space might help in the development of potential countermeasures to prevent cardiovascular deconditioning in astronauts. This could also provide better knowledge of endothelial function on Earth, which could be useful for clinical application centered around endothelial dysfunction.
 

Description
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Applications

Space Applications
Human subjects and experimental animal models returning from space show muscle-skeletal and cardiovascular problems accredited to injury of the endothelium. Because endothelial cells are responsible for the integrity of the vascular wall, a better understanding of the modulation of endothelial functions in space might help in the development of potential countermeasures to prevent cardiovascular deconditioning in astronauts.

Earth Applications
Endothelial cells play a crucial role in maintaining the functional integrity of the vascular wall. Indeed, endothelial dysfunctions promote several diseases, among which atherosclerosis, hypertension, diabetes, and thrombosis. Major alterations of endothelial behavior could also explain the high frequency of cardiovascular disease in the elderly. Improving our knowledge of endothelial function could be useful for clinical application centered around endothelial dysfunction.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

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Related Websites

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Imagery