Immuno-2 (Immuno-2) - 04.18.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
The Immuno-2 investigation provides a holistic approach to increase the knowledge of the complex physiological adaptation of humans during long-term space missions. Increasing the knowledge of immune response adaptation in space helps in the development of pharmacological tools to counter any unwanted immunological side effects during long-duration missions. This could also provide an insight into disease processes of humans on Earth with medical conditions involving comprised immune systems, in turn helping in the development of pharmacological tools to help in the recovery from such conditions.
Science Results for Everyone
Information Pending

The following content was provided by Alexander Chouker, M.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom:

Principal Investigator(s)
Alexander Chouker, M.D., University of Munich, Munich, Germany

Co-Investigator(s)/Collaborator(s)
Sarah Baatout, CEN SCK, Belgian Nuclear Research Centre, Mol, Belgium
Brian E. Crucian, Ph.D., NASA, Johnson Space Center, Houston, TX, United States
Dominique De Quervain, Departments of Medicine & Psychology, University of Basel, Switzerland
Matthias Feuerecker, Department. of Anaesthesiology, Ludwig-Maximilians-University, Munich, Germany
Ines Kaufmann, M.D., University of Munich, Munich, Germany
Nicola Montano, Cardiovascular Neuroscience Lab, University of Milan, Milan, Italy
Boris V. Morukov, Ph.D., M.D., Institute of Medical and Biological Problems, Moscow, Russia
Igor Alexandrovich Nichiporuk, Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Moscow, Russia
Siegfried Praun, Science Management, V&F Medical, Austria
Marina Rykova, Institute for Biomedical Problems (IBMP), Moscow, Russia
Clarence F. Sams, Ph.D., Johnson Space Center, Houston, TX, United States
Gustav Schelling, Department of Anaesthesiology, Ludwig-Maximilians-University, Munich, Germany
Manfred Thiel, Ph.D., M.D., Department of Anaesthesiology and Intensive Care, University of Heidelberg, Mannheim, Germany
Benno Roozendaal, Institute for Neuroscience, University Medical Center Groningen, Groningen, Netherlands

Developer(s)
European Space Agency (ESA), Noordwijk, Netherlands

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
Information Pending

Research Benefits
Earth Benefits, Scientific Discovery

ISS Expedition Duration
March 2015 - March 2016; March 2016 - September 2017

Expeditions Assigned
43/44,45/46,47/48,49/50,51/52

Previous Missions
Information Pending

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Experiment Description

Research Overview
• Humans are challenged in space by psychological/biological (e.g., confinement, sleep, pain) and physical stress factors (e.g., weightlessness, radiation). As a result, the immune system is targeted by a multitude of hormones and hormone-like substances, as well as radiation effects, leading altogether to an imbalance of immune function, which can result in diseases.
• The Immuno-2 investigation provides a holistic approach to increasing the knowledge of the complex physiological adaptation of humans during long-term space missions. This is undertaken by analyzing a variety of parameters from samples taken in orbit, as well as pre- and post-flight (blood, saliva, breath, hair), measuring ECG, blood oxygen levels, and activity, along with psychological testing and questionnaires.

Description
Information Pending

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Applications

Space Applications
This integrative study will provide a holistic approach to increase the knowledge of the complex physiological adaptation of humans during long-term space missions. Increasing our knowledge of immune response adaptation in space will help in the development of pharmacological tools to counter any unwanted immunological side effects during long-duration missions.

Earth Applications
Increasing the understanding of immune response in weightlessness also increases the knowledge of the mechanisms influencing immune response, in general. As such, this investigation could help to provide an insight into the disease processes of humans on Earth with medical conditions involving comprised immune systems. This, in turn, could help in the development of pharmacological tools to help in the recovery from such conditions.

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Operations

Operational Requirements and Protocols
Sessions consists of:
• Blood samples and breath samples collected once per time point.
• Saliva is collected in the morning, the evening, and in the next morning upon completion of Day 2 Memory Tests.
• Hair is collected in the evening at the Saliva evening collection.
• The questionnaires are divided in a morning and evening set on Day 1 and Day 2.
• ECG, pulse oximetry and actigraphy are on the night before blood processing draw and the continuously ECG/Actigraphy/Pulse oximetry monitoring period is approximately 34-36 hours later.
• Minimum 3 sessions: L+~2 weeks to 1 month, L+3-4 months, in last month.
• Sampling requested to be every ~30 days to 45 days, i.e. between 3 and a maximum of 5 times during long-duration mission of 12 months.
• Blood samples in conditioned stowage, other samples (including blood smears) at ambient.

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Decadal Survey Recommendations

Information Pending

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Results/More Information

Information Pending

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Results Publications

    Benjamin CL, Stowe RP, St. John L, Sams CF, Mehta SK, Crucian BE, Pierson DL, Komanduri KV.  Decreases in thymopoiesis of astronauts returning from space flight. JCI Insight. 2016 August 4; 1(12): 8 pp. DOI: 10.1172/jci.insight.88787.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites

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Imagery