AIRWAY MONITORING (AIRWAY MONITORING) - 11.22.16

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
With dust particles present in the International Space Station atmosphere, Airway Monitoring studies the occurrence and indicators of airway inflammation in crewmembers, using ultra-sensitive gas analysers to analyse exhaled air. This helps to highlight any health impacts and to maintain crewmember well-being on future human spaceflight missions, especially longer-duration missions to the Moon and Mars for example, where crewmembers will have to be more self-sufficient in highlighting and avoiding such conditions.
 
Science Results for Everyone
Information Pending

The following content was provided by Lars L. Karlsson, Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom: Airway Monitoring

Principal Investigator(s)
Lars L. Karlsson, Ph.D., Karolinska Institutet, Stockholm, Sweden

Co-Investigator(s)/Collaborator(s)
Lars E. Gustafsson, Ph.D., Karolinska Institutet, Stockholm, Sweden
Dag Linnarsson, Karolinska Institute, Stockholm, Sweden
Alain Van Muylem, Universite┬┤ Libre de Bruxelles, Brussells, Belgium

Developer(s)
European Space Agency (ESA), Noordwijk, Netherlands

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
September 2014 - March 2015; September 2015 - March 2016; March 2016 - February 2017

Expeditions Assigned
41/42,45/46,47/48,49/50

Previous Missions
Information Pending

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Experiment Description

Research Overview

  • The presence of nitric oxide (NO) in exhaled air has been known since many years, but the exact localization of the NO formation is still controversial. NO is normally present in exhaled air in trace amounts, but using modern ultra-sensitive gas analyzers it can be used as an indicator for airway inflammation. During space missions the crewmembers are exposed to an increased risk of inspiring free-floating dust and particles due to the microgravity environment; and in future Lunar and Martian habitats, crewmembers are exposed to the risk of inhaling Moon and Mars dust, which is considered more toxic than terrestrial dust, and therefore might induce airway inflammation.
  • The experiment aims to determine in detail the pulmonary nitric oxide turnover in weightlessness and in combined weightless, hypobaric and hypoxic environments as well as determining the lung diffusion capacity for nitric oxide.
  • On future human exploration missions where a greater degree of self-sufficiency will be necessary to secure a productive and fruitful mission, also with respect to medical diagnostics and treatment, this type of research will form the cornerstone of planning for such eventualities that centre on the occurrence of airway inflammation in astronauts. As such this research forms a basis for alleviating and avoiding such issues that may occur by monitoring airway health through the measurement of exhaled nitric oxide. This will help to highlight environmental conditions that exacerbate/alleviate the situation and help to determine countermeasures to reduce the possibility of inflammation occurring and hence optimise the health and performance of astronauts on long-duration exploration missions. This research will also provide new insights in nitric oxide physiology, which could improve the diagnostic use of exhaled nitric oxide on Earth and thus benefit patients with asthma or other airway inflammatory diseases.

Description
Information Pending

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Applications

Space Applications
On future human exploration missions where a greater degree of self-sufficiency will be necessary to secure a productive and fruitful mission, and with respect to medical diagnostics and treatment, this type of research will form the cornerstone of planning for eventualities that centre on the occurrence of airway inflammation in astronauts. This is done by monitoring airway health through the measurement of exhaled nitric oxide. Monitoring these measurements helps to highlight environmental conditions that exacerbate/alleviate airway inflammation, and helps in the  development of countermeasures to reduce the possibility of its occurrence. This, in turn, can help to optimise the health and performance of astronauts on long-duration exploration missions.
 

Earth Applications
ESA research has helped in the development of diagnostic tools which quantify airway inflammation, tools which not only help in spaceflight diagnostics, but that also hold applications on earth within diagnostics of similar conditions, for example monitoring of asthma. This research will provide new insights in nitric oxide physiology, which could improve the diagnostic use of exhaled nitric oxide on Earth and thus benefit patients with asthma or other airway inflammatory diseases.
 

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Operations

Operational Requirements and Protocols
Information Pending

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Decadal Survey Recommendations

Information Pending

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Results/More Information

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Related Websites

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Imagery

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NASA Image ISS042E049017 - ESA astronaut Samantha Cristoforetti on board the International Space Station working with equipment for the Airway Monitoring investigation.

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