Structural Research on Protein Candidates for an AIDS Vaccine in Earth and Space Conditions (Vaktsina-K (Vaktsina-K (Vaccine-K)) - 03.14.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
The Structural Research on Protein Candidates for an AIDS Vaccine in Earth and Space Condition (Vaktsina-K) investigation aims to create a new generation of vaccines against viral infections based on artificial proteins with predetermined antigenicity and immunogenicity. Analysis of the spatial structure provides information on the conformation of the active center and on the efficacy of the protein construction, and allows necessary changes to be introduced in order to increase the biological activity of artificial proteins.
Science Results for Everyone
Information Pending

The following content was provided by L. S. Sandakhchiev, G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
L. S. Sandakhchiev, Biopreparat, Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
April 2004 - October 2005; April 2006 - September 2006; October 2007 - October 2008

Expeditions Assigned
9,10,11,13,16,17

Previous Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
Information Pending

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Applications

Space Applications
As a result of Vaktsina-K, the spatial structure of the protein monocrystals obtained are being studied, the mechanism of their action is being determined, and the possibility of using the information obtained to create new pharmaceuticals is being assessed to facilitate the creation of new vaccines against harmful viral diseases.

Earth Applications
Improvements in the technology for producing biocrystals in microgravity and development of crystallographic research in space will make it possible to obtain high-quality protein crystals.

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Operations

Operational Requirements and Protocols
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Decadal Survey Recommendations

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Results/More Information

As a result of the use of several types of precipitants for crystallizing TBI protein in microgravity, monocrystals were obtained that were several times greater in size than those grown on Earth. In a number of instances, the total dimensions of the crystals permitted testing of their quality (reflective capability) using X-ray diffraction methods. Vaktsina-K resulted in crystals of rod-like or tubular shape, or without defined facets with a maximum size of about 200 μm in the presence of amorphous precipitation.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Luch-2 equipment accommodating multipurpose crystallization cassettes.
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image Thermal insulating container Biokont-T for transportation of the Luch-2 equipment.
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image Temperature-stable container "AQUA 01".
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