Comprehensive Study of the Pattern of Main Indicators of Cardiac Activity and Blood Circulation (Cardio-ODNT) (Cardio-ODNT) - 05.09.18

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Comprehensive Study of the Pattern of Main Indicators of Cardiac Activity and Blood Circulation (Cardio-ODNT) identifies the associations in regulation of human systemic and pulmonary circulation during the stages of individual adaptation to conditions of long-term microgravity using functional load testing along with the application of negative pressure to the lower part of the body (LBNP) in order to assess and predict orthostatic intolerance (dizziness upon standing up).
Science Results for Everyone
These pants are tight for a good reason. Space station crewmembers wore a lower body negative pressure suit to evaluate cardiac activity and circulation in the legs in microgravity. The results clarified microgravity’s effect on blood vessels in the legs and showed which regions of the body are most affected by long-term exposure. Using the suit to apply negative pressure to the legs during flight had positive effects on circulation throughout the body, but particularly in the pulmonary region, which is most affected by microgravity. Results indicated that sessions in the pressure suit will be useful in helping prepare crewmembers for return to Earth.

The following content was provided by Valery V. Bogomolov, M.D., Ph.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Valery V. Bogomolov, M.D., Ph.D., Institute for Biomedical Problems, Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
October 2004 - April 2005; October 2005 - April 2006; September 2006 - October 2008

Expeditions Assigned
10,12,14,15,16,17

Previous Missions
Information Pending

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Experiment Description

Research Overview
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Description
Information Pending

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Applications

Space Applications
The adaptation mechanisms of various levels of the human circulatory system in microgravity can be clarified from studying the functional capabilities of the human body in spaceflight. The scientific information obtained make it possible to analyze and evaluate the functional state of the cardiovascular system overall, and in particular the filling capacity and tone of blood vessels of various sizes in each region tested in accordance with criteria generally accepted in normal clinical practice, including determining functional state ranges (high, normal, and low blood pressure, high and low blood volume). Results from this study adds substantially to the knowledge of the impact of microgravity on the functional state of various parts of the cardiovascular system of crew members in long-term spaceflights.

Earth Applications
The scientific results of the Cardio-ODNT experiment are intended for doctors working mainly on the medical support of manned spaceflights. New knowledge is expected to be the major benefit of this investigation.

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Operations

Operational Requirements and Protocols
Information Pending

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Decadal Survey Recommendations

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Results/More Information

Objective information was obtained for the first time enabling the functional state of various regions of the systemic and the pulmonary circuit to be comprehensively evaluated with LBNP in microgravity. The feedback mechanisms of vessels in the systemic and pulmonary circuits were clarified. Results showed that the hemodynamic state of the body was significantly different before and during flight. The features of adaptation reactions for each region studied and their relationships upon simulating a vertical position using LBNP were identified, depending on the original hemodynamic state of the body. The regions that are the most impacted by long-term microgravity were determined. The data obtained highlighted the positive benefits of exposing the lower body to negative pressure during flight on the hemodynamic equilibrium in the body in general, and in particular on circulation in the pulmonary circuit, which is most affected by microgravity. Data confirmed the effectiveness of LBNP sessions on the circulatory system during crew member training for the return to Earth.

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Results Publications

    Kotovskaya AR, Fomina GA.  Human venous hemodynamics in microgravity and prediction of orthostatic tolerance in flight. Human Physiology. 2015 December 22; 41(7): 699-703. DOI: 10.1134/S0362119715070063. PMID: 23700615. [Russian. Original Russian Text © A.R. Kotovskaya, G.A. Fomina, 2013, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2013, Vol. 47, No. 1, pp. 37–42.]

    Turchaninova VF, Alfyorova IV, Krivolapov VV.  Several aspects of a comparative analysis of hemodynamic reactions to LBNP in crewmembers from various age groups. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2010; 44(1): 20-25. DOI: 10.1134/S0362119712070249. [Also: Turchaninova, V. F., I. V. Alferova, and V. V. Krivolapov, ‘Some Aspects of the Comparative Analysis of Hemodynamic Responses to LBNP Tests in Cosmonauts of Different Age Groups’, Human Physiology, 38 (2012), 721–26 http://dx.doi.org/10.1134/S0362119712070249  ]

    Turchaninova VF, Alferova IV, Krivolapov VV, Liamin VR, Beliaev AP.  Dependence of the circulation system functioning on cosmonaut age according to the results of physical loading tests on a veloergometer. Human Physiology. 2013 December 29; 39(7): 707-711. DOI: 10.1134/S0362119713070189. [

    Original Russian Text © V.F. Turchaninova, I.V. Alferova, V.V. Krivolapov, V.R. Liamin, A.P. Beliaev, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 5, pp. 8–12.]

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Chibis pneumatic-vacuum suit. Image courtesy of Russian Space Agency (FSA).
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image Gamma-1M hardware. Image courtesy of Russian Space Agency (FSA).
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