The Structures, Propulsion, And Control Engineering (SPACE) University Research Center (URC) was established in 2003 at the California State University, Los Angeles (CSULA) with NASA funding of $6 million.
WaterSCAPES: Science of Coupled Aquatic Processes in Ecosystems from Space is a University Research Center based at Florida International University in Miami, Florida.
The Beltsville Center for Climate System Observation (BCCSO) was established at Howard University through a cooperative agreement with NASA in 2008, to promote research and education in the study of atmospheric sciences, while producing a well qualified, diverse workforce.
The Center of Excellence in Systems Engineering for Space Exploration Technologies (CESET) was established in 2009 at Morgan State University's Clarence M. Mitchell, Jr. School of Engineering to promote research and education in Space Exploration Technologies, Systems Engineering and Systems Engineering Management.
The Center for Radiation Engineering and Science for Space Exploration (CRESSE), a NASA University Research Center (URC) at Prairie View A&M University, uses its core intellectual, academic and physical infrastructure to thoroughly investigate the scientific and engineering challenges of space radiation.
The Center for Bionanotechnology and Environmental Research (CBER) was established at Texas Southern University to identify, understand and design countermeasures to mitigate the risks associated with environmental hazards that astronauts encounter while in space.
The Center for Advanced Nanoscale Materials (CANM), located at The University of Puerto Rico – Rio Piedras, unites thirteen researchers, from three different campuses and four different departments, to work on research projects relevant to NASA.