Medaka Osteoclast (Medaka Osteoclast) - 09.17.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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Science Objectives for Everyone
Enhancement of the osteoclast (bone resorption cell) is assumed to cause the decrease of bone mineral density in space. Medaka fish is a model animal for the life science research, and JAXA plans to study the effects of microgravity on the osteoclast activity and the gravity sensing system of the vertebulate using Medaka fish on board the Kibo Module.

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Information Pending

The following content was provided by Akira Kudo, and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Japan Aerospace and Exploration Agency (JAXA).

Experiment Details


Principal Investigator(s)

  • Akira Kudo, Tokyo Institute of Technology, Japan

  • Co-Investigator(s)/Collaborator(s)
  • Yoshiro Takano, Tokyo Medical and Dental University, Tokyo, Japan
  • Keiji Inohaya, Tokyo Institute of Technology
  • Masahiro Chatani, Tokyo Institute of Technology, Yokohama, Japan
  • Akiko Mantoku, Tokyo Institute of Technology, Japan
  • Kazuhiro Takeyama, Tokyo Institute of Technology, Japan

  • Developer(s)
    Information Pending
    Sponsoring Space Agency
    Japan Aerospace Exploration Agency (JAXA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    September 2012 - September 2013

    Expeditions Assigned

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview

    • During the space flight, bone mineral density is decreased by the influence of osteoclast activation, which molecular mechanism is expectantly investigated. To find the effect of microgravity on osteoclast in space, we perform a long-term experiment with small fresh water fish, medaka, and examine the alteration of osteoclast activity under microgravity with the histological analysis or the gene expression analysis by RNA in-situ hybridization.

    • Medaka will be launched by SpaceX-2 and 2months experiment will be started using the Aquatic Habitat. After approx. 2weeks, 1month, and 2months from the experiment start, medaka will be sampled from the Aquatic Habitat Aquariums and chemically fixed for the retrieval. Also, the Aquatic Habitat maintenance operations, such as water sampling, water quality check, water exchange, and ORU exchanges are planned.

    • Fixed samples will be retrieved by SpaceX-2 and SpaceX-3.

    Information Pending

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    Space Applications
    Information Pending

    Earth Applications
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    Operational Requirements
    Information Pending

    Operational Protocols
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    Results/More Information

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    Related Websites

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    image Aquarium holding the Medaka Osteoclast ground testing (JAXA)
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