Medaka Osteoclast (Medaka Osteoclast) - 08.27.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Enhancement of the osteoclast (bone resorption cell) is assumed to cause the decrease of bone mineral density in space. Medaka fish is a model animal for the life science research, and JAXA plans to study the effects of microgravity on the osteoclast activity and the gravity sensing system of the vertebulate using Medaka fish on board the Kibo Module.
Science Results for Everyone
Information Pending

The following content was provided by Akira Kudo, and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Japan Aerospace and Exploration Agency (JAXA).
Experiment Details


Principal Investigator(s)
Akira Kudo, Tokyo Institute of Technology, Japan

Yoshiro Takano, Tokyo Medical and Dental University, Tokyo, Japan
Keiji Inohaya, Tokyo Institute of Technology
Masahiro Chatani, Tokyo Institute of Technology, Yokohama, Japan
Akiko Mantoku, Tokyo Institute of Technology, Japan
Kazuhiro Takeyama, Tokyo Institute of Technology, Japan

Information Pending

Sponsoring Space Agency
Japan Aerospace Exploration Agency (JAXA)

Sponsoring Organization
Japan Aerospace Exploration Agency

Research Benefits
Information Pending

ISS Expedition Duration 1
September 2012 - September 2013

Expeditions Assigned

Previous ISS Missions
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Experiment Description

Research Overview

  • During the space flight, bone mineral density is decreased by the influence of osteoclast activation, which molecular mechanism is expectantly investigated. To find the effect of microgravity on osteoclast in space, we perform a long-term experiment with small fresh water fish, medaka, and examine the alteration of osteoclast activity under microgravity with the histological analysis or the gene expression analysis by RNA in-situ hybridization.

  • Medaka will be launched by SpaceX-2 and 2months experiment will be started using the Aquatic Habitat. After approx. 2weeks, 1month, and 2months from the experiment start, medaka will be sampled from the Aquatic Habitat Aquariums and chemically fixed for the retrieval. Also, the Aquatic Habitat maintenance operations, such as water sampling, water quality check, water exchange, and ORU exchanges are planned.

  • Fixed samples will be retrieved by SpaceX-2 and SpaceX-3.

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Space Applications
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Earth Applications
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Operational Requirements
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Operational Protocols
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Results/More Information

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Related Websites

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image Aquarium holding the Medaka Osteoclast ground testing (JAXA)
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