Medaka Osteoclast (Medaka Osteoclast) - 12.03.13
Science Objectives for Everyone
Enhancement of the osteoclast (bone resorption cell) is assumed to cause the decrease of bone mineral density in space. Medaka fish is a model animal for the life science research, and JAXA plans to study the effects of microgravity on the osteoclast activity and the gravity sensing system of the vertebulate using Medaka fish on board the Kibo Module.
Science Results for Everyone
Japan Aerospace Exploration Agency (JAXA)Sponsoring Organization
Information PendingResearch Benefits
Information PendingISS Expedition Duration:
September 2012 - September 2013Expeditions Assigned
33/34,35/36Previous ISS Missions
- During the space flight, bone mineral density is decreased by the influence of osteoclast activation, which molecular mechanism is expectantly investigated. To find the effect of microgravity on osteoclast in space, we perform a long-term experiment with small fresh water fish, medaka, and examine the alteration of osteoclast activity under microgravity with the histological analysis or the gene expression analysis by RNA in-situ hybridization.
- Medaka will be launched by SpaceX-2 and 2months experiment will be started using the Aquatic Habitat. After approx. 2weeks, 1month, and 2months from the experiment start, medaka will be sampled from the Aquatic Habitat Aquariums and chemically fixed for the retrieval. Also, the Aquatic Habitat maintenance operations, such as water sampling, water quality check, water exchange, and ORU exchanges are planned.
- Fixed samples will be retrieved by SpaceX-2 and SpaceX-3.
Information PendingEarth Applications
Information PendingOperational Protocols
Aquarium holding the Medaka Osteoclast ground testing (JAXA)
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