The effect of long-term microgravity exposure on cardiac autonomic function by analyzing 48-hours electrocardiogram (Biological Rhythms 48hrs) - 12.10.14

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Biological Rhythms 48 hours studies the effects of long-term microgravity exposure on heart function by analyzing an astronaut’s electrocardiogram for 48 hours. While space station keeps Houston time, it remains unknown whether a separate biological rhythm is imposed on long-term flight crews. To study this astronauts wear an Actiwatch sleep monitor for 96 hours and a Holter electrocardiograph for 48 hours in the middle of that sequence.

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Information Pending

The following content was provided by Chiaki Mukai, M.D., Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Japan Aerospace and Exploration Agency (JAXA).

Experiment Details


Principal Investigator(s)

  • Chiaki Mukai, M.D., Ph.D., Japan Aerospace Exploration Agency, Tsukuba, Japan

  • Co-Investigator(s)/Collaborator(s)
  • Hiroshi Ohshima, M.D., Ph.D., Japan Aerospace and Exploration Agency, Ibaraki, Japan
  • Ichiro Tayama, Chiyoda Advanced Solutions Corporations , Yokohama, Japan
  • Shin Yamada, M.D., Ph.D., Japan Aerospace Exploration Agency, Tsukuba, Japan
  • Tatsuya Aiba, Tsukuba Space Center, Ibaraki, Japan
  • Satoru Ishida, Tsukuba Space Center, Ibaraki, Japan
  • Naomune Yamamoto, Tokyo Women's Medical University, Japan
  • Yasushi Mizuno, JAXA, Japan

  • Developer(s)
    Japan Aerospace Exploration Agency (JAXA), Tsukuba, , Japan

    Sponsoring Space Agency
    Japan Aerospace Exploration Agency (JAXA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    May 2012 - Ongoing

    Expeditions Assigned

    Previous ISS Missions
    We conducted continuous 24-hour RR intervals measurement in ten crews for preliminary data of this project. The preliminary data showed various changes on biological rhythms and some biological rhythm of crews showed prolonged for 24hours or more than those before and after flight.

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    Experiment Description

    Research Overview

    • To clarify the change of an accurate biological clock from space circumstance.

    • We will evaluate continuous 48-hour RR intervals measurement on Holter ECG ,and sleep/wake rhythm on actiwatch for 96-hour.

    • This research will be analyzed for improving the health care technology of long duration astronauts, for checking out the difference of them between before and after the flight on the earth and during long-duration space flight.

    Information Pending

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    Space Applications

    Monitoring cardio autonomic functions is important for improving crew health technology during long-duration space flight. 

    Earth Applications

    The crew health care technology for the biological rhythm disruption during space flight provides general public with useful hint to promote healthy daily lifestyle. 

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    Operational Requirements
    Information Pending

    Operational Protocols
    Information Pending

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    Results/More Information

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    Related Websites

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    image Holter ECG. Image courtesy of JAXA.
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