Effects of Microgravity on the Haemopoietic System: A Study on Neocytolysis (Neocytolysis) - 02.15.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
ISS Science for Everyone

Science Objectives for Everyone Early studies on astronauts found that anemia (decrease of red blood cells in the blood stream) of individuals returning from a space flight was due to selective hemolysis (destruction of red blood cells), neocytolysis. The Neocytolysis investigation, can lead to treatments of different types of anemia, especially those related to renal failure or acute infections.

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This content was provided by Angela Maria Rizzo, Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.

Experiment Details

OpNom

Principal Investigator(s)

  • Angela Maria Rizzo, Ph.D., University of Milan, Milan, Italy

  • Co-Investigator(s)/Collaborator(s)
  • Maria E. Cosulich, Ph.D., UniversitÓ di Pavia, Pavia, Italy
  • Guglielmo Antonutto, M.D., University of Udine, Udine, Italy
  • Giampaolo Minetti, University of Pavia, Pavai, Italy

  • Developer(s)
    Italian Space Agency (ASI), Rome, , Italy

    Sponsoring Space Agency
    European Space Agency (ESA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    September 2006 - April 2008

    Expeditions Assigned
    14,15,16

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview

    • Neocytolysis (selective destruction of red blood cells) occurring in astronauts is an acute adaptive response triggered by the exposure to microgravity under normal oxygen pressure.


    • Blood samples drawn from astronauts before and after a short duration space flight to ISS will be analyzed by investigators to determine the factors which contribute to neocytolysis and determine a treatment.

    Description
    For decades, it has been reproducibly demonstrated that astronauts journeying in space for even a few days return to earth with a significant, symptomatic anemia. A previously unsuspected physiologic process that selectively hemolyzes the youngest circulating red blood cells under conditions of red cell excess, termed neocytolysis, is responsible for this change. This process is operative not only in space flight, but it is generalizable to other physiologic adaptive and pathophysiologic maladaptive situations. For example, neocytolysis occurs when polycythemic individuals acclimated to high altitude are transported to sea level and can be prevented by erythropoietin (EPO) injections. Renal failure represents a pathophysiologic situation in which EPO is depressed, and neocytolysis may be related to the anemia of renal failure. The recognition of neocytolysis is leading to a fresh look at the basis underlying a number of hematologic disorders.

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    Applications

    Space Applications
    Information Pending

    Earth Applications
    Information Pending

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    Operations

    Operational Requirements
    Information Pending

    Operational Protocols
    Blood samples drawn from astronauts before and after a short duration space flight to ISS will be analyzed by investigators to determine the factors which contribute to neocytolysis and determine a treatment.

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    Results/More Information

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    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

      Rizzo AM, Rizzo AM, Tell G, Vascotto C, Costessi A, Costessi A, Arena S, Scaloni A, Cosulich ME.  Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: A proteomics study. Proteomics. 2005; 5(7): 1827-1837.

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    Related Websites
    The information on this page is provided courtesy of the ESA Erasmus Experiment Archive.
    Columbus Mission - European Experiment Programme

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    Imagery

    image Healthy red blood cells (upper left) are smooth and round. Hemolytic red blood cells (lower right). Image courtesy of The Cleveland Clinic, Cleveland, OH.
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