Myotendinous and Neuromuscular Adaptation to Long-termSpaceflight (Sarcolab) - 12.03.13
Science Objectives for Everyone
Myotendinous and Neuromuscular Adaptation to Long-term Spaceflight (Sarcolab) investigates skeletal muscle fibers of humans exposed to long-term space flight.
Science Results for Everyone
European Space Agency (ESA)Sponsoring Organization
Information PendingResearch Benefits
Information PendingISS Expedition Duration:
September 2011 - March 2014Expeditions Assigned
29/30,31/32,35/36,37/38Previous ISS Missions
- Exposure to actual and simulated microgravity is known to lead to loss of muscle mass, function and motor control.
- The first goal of this project is to investigate the myotendinous structural and functional determinants of this phenomenon using an in vivo and in vitro approach. Whole skeletal muscle in vivo (plantarflexors) and in vitro on isolated muscles fibers (of the soleus muscle (SOL) which are most affected by microgravity) will be studied for humans exposed to long-term spaceflight.
- The second goal of this project is to characterize reflex excitability of the dis-used muscles.
By improving the understanding of the mechanisms behind loss of muscle mass in space we in turn can develop more effective countermeasures for the crews, whether pharmacological, dietary or exercise-based in order to alleviate such adverse effects and hence improve/maintain the health and performance of our astronauts in orbit.Earth Applications
By improving the understanding of the mechanisms behind loss of muscle mass in space and developing appropriate and effective countermeasures to any adverse effects we can also draw conclusions and get insights into certain muscular conditions on Earth. An adaptation of countermeasures originally developed for in-space use by astronauts, or newly developed ground-based countermeasures could be used within rehabilitation of patients affected by such medical conditions.
Information PendingOperational Protocols