Myotendinous and Neuromuscular Adaptation to Long-term Spaceflight (Sarcolab) - 06.09.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Myotendinous and Neuromuscular Adaptation to Long-term Spaceflight (Sarcolab) investigates the adaptation and deterioration of the soleus, or calf muscle, where it joins the Achilles tendon, which links it to the heel and carries loads from the entire body. Muscle fiber samples are taken from crew members before and after flight, and analyzed for changes in structural and chemical properties. MRI and ultrasound tests and electrode stimulation are conducted to help assess muscle and tendon changes caused by microgravity exposure.
Science Results for Everyone
Information Pending

The following content was provided by P. Cerretelli, C. Pérot, and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom:

Principal Investigator(s)
P. Cerretelli, Italy
C. Pérot, France

Co-Investigator(s)/Collaborator(s)
M. Narici, Italy
F. Canon, France
R. Bottinelli, Italy
C Gelfi, Italy
C. Franceschi, Italy
M. Capri, Italy
M. Flück, United Kingdom
J. Latsch, Germany
C. Maganaris, Greece
Jorn Rittweger, Manchester Metropolitan University, Alsager, United Kingdom
O. Seynnes, United Kingdom
C. Marques, France
D. Gamet, France
S. Boudaoud, France
D. Lambertz, France
F. Goubel, France
A. Minetti, United Kingdom
Carlo Reggiani, Italy
P. Capodaglio, Italy
David L. Costill, Ph.D., Ball State University, Muncie, IN, United States
C L. LeBlanc
Scott W. Trappe, Ph.D., Ball State University, Muncie, IN, United States

Developer(s)
Information Pending

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
September 2011 - Ongoing

Expeditions Assigned
29/30,31/32,35/36,37/38,47/48

Previous ISS Missions
Information Pending

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Experiment Description

Research Overview

  • Exposure to actual and simulated microgravity is known to lead to loss of muscle mass, function and motor control.
  • The first goal of this project is to investigate the myotendinous structural and functional determinants of this phenomenon using an in vivo and in vitro approach. Whole skeletal muscle in vivo (plantarflexors) and in vitro on isolated muscles fibers (of the soleus muscle (SOL) which are most affected by microgravity) will be studied for humans exposed to long-term spaceflight.
  • The second goal of this project is to characterize reflex excitability of the dis-used muscles.

Description
Information Pending

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Applications

Space Applications
By improving the understanding of the mechanisms behind loss of muscle mass in space, we, in turn, can develop more effective countermeasures for the crews, whether pharmacological, dietary or exercise-based in order to alleviate such adverse effects and hence improve/maintain the health and performance of our astronauts in orbit.

Earth Applications
By improving the understanding of the mechanisms behind loss of muscle mass in space and developing appropriate and effective countermeasures to any adverse effects, we can also draw conclusions and get insights into certain muscular conditions on Earth. An adaptation of countermeasures originally developed for in-space use by astronauts, or newly developed ground-based countermeasures could be used within rehabilitation of patients affected by such medical conditions.

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Operations

Operational Requirements
Information Pending

Operational Protocols
Information Pending

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Results/More Information

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Related Websites

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Imagery