Biological Effects of Space Radiation and Microgravity on Mammalian Cells (NeuroRad)
04.26.13
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Overview | Description | Applications | Operations | Results | Publications | Imagery
Experiment Overview
This content was provided by Hideyuki J. Majima, Ph.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Japan Aerospace and Exploration Agency (JAXA).
Brief Summary
Biological Effects of Space Radiation and Microgravity on Mammalian Cells (NeuroRad) studies the effects of space radiation on the human neuroblastoma cell (nerve cell containing a tumor) line in microgravity.
Principal Investigator(s)
Hideyuki J. Majima, Ph.D., Kagoshima University, Kagoshima, Japan
Co-Investigator(s)/Collaborator(s)
Information Pending
Developer(s)
Information Pending
Sponsoring Space Agency
Japan Aerospace Exploration Agency (JAXA)
Sponsoring Organization
Information Pending
Research Benefits
Information Pending
ISS Expedition Duration
March 2010 - September 2010
Expeditions Assigned
23/24
Previous ISS Missions
NeuroRad was first operated on ISS Expedition 19/20.
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Experiment Description
Research Overview
- NeuroRad will investigate the biological effects of space radiation on mammalian nerve cells using SK-N-SH (human neuroblastoma cell line).
- NeuroRad will evaluate the risk factors of long-term space flight by investigating the ability to recover from radiation damage aquired in microgravity. NeuroRad will also evaluate the effects of radiation accumulation as a result of long-term space flight missions.
- NeuroRad will focus on changes in the mitochondria-related gene expression, since the mitochondria is well known for having a crucial role in apotosis (programmed cell death).
- After recovery, the effects of radiation in microgravity will be comprehensively analyzed using the following techniques: nuclear DNA microaray, western blotting, and mutation assays.
Description
Information Pending
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Applications
Space Applications
Information Pending
Earth Applications
Radiation effects are critical for biological creatures. The data collected during this investigation may lead a greater understanding of how the radiation defense system is affected by different factors from space radiation and microgravity environment. The data could be applied to develop new treatments and preventative measures for the effects of radiation, and to further investigate the effects of human long-duration stays in space.
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Operations
Operational Requirements
Information Pending
Operational Protocols
Information Pending
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Results/More Information
Information Pending
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Related Websites
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Imagery
