Physiological Parameters that Predict Orthostatic Intolerance After Spaceflight (Heart) - 03.12.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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This content was provided by John M. Karemaker, and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.

Experiment Details

OpNom

Principal Investigator(s)

  • John M. Karemaker, University of Amsterdam, Amsterdam, Netherlands

  • Co-Investigator(s)/Collaborator(s)
    Information Pending
    Developer(s)
    University of Amsterdam, Amsterdam, , Netherlands

    Sponsoring Space Agency
    European Space Agency (ESA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    October 2003 - October 2004

    Expeditions Assigned
    8,9

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Description
    The main scientific objectives of the experiment are to define physiological parameters that may serve to pinpoint those subjects that have poor orthostatic tolerance under unfavourable conditions. This may, eventually, help in diagnosis of unexplained faints in patients.

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
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    Operational Protocols
    This experiment will provide further data already obtained from similar research performed on the Belgian Soyuz Mission Odissea of ESA astronaut Frank De Winne in 2002, and the Spanish Soyuz Mission Cervantes of ESA astronaut Pedro Duque in 2003. The objective is to predict orthostatic intolerance, i.e. the inability to stand upright, of astronauts who have spent a long period in a weightless environment. The predictions will be based on the measurements of physical parameters such as blood pressure, electrocardiograms, thoracic impedance and brain blood flow by ultrasound. This data will serve as input for the characteristics of a particular subject into a computer model of the circulation The astronauts are tested pre-flight and post-flight in a ground-based lab using a computerized tilting table that can induce a variety of dynamic tilt manoeuvres These parameters will act as predictors for the outcome of the test, where astronauts are asked to stand relaxed, leaning against a wall for a maximum of 10 minutes. Orthostatic intolerance is defined as the inability to stand for 10 minutes .

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    Results/More Information
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    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    ESA Erasmus Experiment Archive

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    Imagery