Characteristics of Pharmacological Responses (absorption, distribution and elimination of acetominophene) in Long Duration Space Flight (Pharma) - 02.25.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Take two super-powered capsules and do not call me in the morning. In space, doses of acetaminophen are more powerful than on Earth. This research also showed that space-flight conditions do not disrupt liver function, making it unlikely that changes occur in the first-pass effect, a phenomenon by which organs such as the liver reduce the dose before a drug reaches its target. This study of the mechanism of drug absorption and elimination was also the first to compare the effectiveness of tablet versus capsule forms of acetaminophen. The data show that capsules are preferable to tablets for treatment in spaceflight.

The following content was provided by I B. Goncharov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)

  • I B. Goncharov, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

  • Co-Investigator(s)/Collaborator(s)
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    Developer(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    March 2001 - October 2005

    Expeditions Assigned
    2,3,4,5,6,7,8,9,10,11

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Description
    An integrated study of distinctive features of the mechanism of distribution and elimination of pharmaceutical preparations under prolonged space flight conditions.

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
    Reflotron-4 Complexfor functional investigation of liver by blood count, Saliva-F Kit for sampling saliva from oral cavity.

    Operational Protocols
    Study of therapeutic efficiency of a medicinal preparation on a human organism exposed to space flight factors.

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    Results/More Information

    Obtaining new information on specific features of absorption, distribution and elimination of acetominophene medicinal preparation.

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    Results Publications

      Kovachevich IV, Goncharov IB, Repenkova LG.  Particulars of pharmacokinetics of drugs during spaceflights on the ISS. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 2004; 90(8): 335-336.

      Kovachevich IV, Kondratenko SN, Starodubtsev AK, Zolkina IV.  Study of pharmacokinetics of paracetamol in terms of the dynamics of its distribution in the blood and saliva of volunteers. Applied Scientific Conference on Clinical Pharmacology in Russia; 2004 104.

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    Imagery

    image A Saliva F kit.
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    image The Reflotron-4 equipment.
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