Characteristics of Pharmacological Responses (absorption, distribution and elimination of acetominophene) in Long Duration Space Flight (Pharma) - 07.14.16
Information Pending Science Results for Everyone
Take two super-powered capsules and do not call me in the morning. In space, doses of acetaminophen are more powerful than on Earth. This research also showed that space-flight conditions do not disrupt liver function, making it unlikely that changes occur in the first-pass effect, a phenomenon by which organs such as the liver reduce the dose before a drug reaches its target. This study of the mechanism of drug absorption and elimination was also the first to compare the effectiveness of tablet versus capsule forms of acetaminophen. The data show that capsules are preferable to tablets for treatment in spaceflight. Experiment Details
I B. Goncharov, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia
Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
ISS Expedition Duration
March 2001 - December 2002; November 2002 - May 2003; April 2003 - October 2005
An integrated study of distinctive features of the mechanism of distribution and elimination of pharmaceutical preparations under prolonged space flight conditions.
Operational Requirements and Protocols
Reflotron-4 Complexfor functional investigation of liver by blood count, Saliva-F Kit for sampling saliva from oral cavity.
Study of therapeutic efficiency of a medicinal preparation on a human organism exposed to space flight factors.
Decadal Survey Recommendations
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Obtaining new information on specific features of absorption, distribution and elimination of acetominophene medicinal preparation.^ back to top
Kovachevich IV, Goncharov IB, Repenkova LG. Particulars of pharmacokinetics of drugs during spaceflights on the ISS. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 2004; 90(8): 335-336.
Kovachevich IV, Kondratenko SN, Starodubtsev AK, Zolkina IV. Study of pharmacokinetics of paracetamol in terms of the dynamics of its distribution in the blood and saliva of volunteers. Applied Scientific Conference on Clinical Pharmacology in Russia; 2004 104.
Ground Based Results Publications
Energia - Science Research on the ISS Russian Segment
A Saliva F kit.
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The Reflotron-4 equipment.
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