Extraction and Investigation of surface glycoproteins E1-E2 Alphavirises on Earth and in Space (Glykoproteid-K) - 07.14.16
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K. A. Miroshnikov, Shubnikiv Institut of Crystallograhy of Russian Academy of Sciences (IC RAS), Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia
Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
ISS Expedition Duration
April 2005 - October 2005; April 2006 - September 2006; October 2007 - October 2008
Acquisition of data on an atomic structure of biomolecules of glycoproteins E1-E2 of the maximum high resolution to produce effective and safe vaccines of a new generation and develop new antiviral preparations and diagnostic systems.
Test of the crystallization process, production of crystals of glycoproteins E1-E2 analogs of alpha viruses in microgravity conditions to make the subseauent ground roentgenodiffraction analysis.
Operational Requirements and Protocols
Kriogem-03M Refrigerator to maintain proper temperature while onboard, Reusable Heat-insulated container with cold accumulator TVK-M, Maintain proper temperature while returning the crystals to the Earth, CPCF Module to grow the protein crystals in orbit and deliver to Earth, Activation Device to activate crystal growth process.
Obtain crystals of alpha-virus E1-E2 glicoproteins analogs.
Decadal Survey Recommendations
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Universal biocrystallization cassettes and experiment footage returned to the Earth.^ back to top
Ground Based Results Publications
Tsygannik IN, Artemyev IV, Arkhipova SF, Pletnyev VZ, Scherbakov GY. Crystallization of proteins in microgravity . Scientific and Technical Conference on the Main Results of Applied Scientific Research on the ISS RS, Korolev, Russia; 2007
Energia - Science Research on the ISS Russian Segment
Kriogem-03M Refridgerator maintains proper temperature onboard. Reusable heat-insulated container with cold accumulator TVK-M maintains proper temperature while returning the crystals to the Earth. CPCF Module grows the protein crystals in the orbit and delivery to the Earth. Activation Device activates crystal growth process.
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