Extraction and Investigation of surface glycoproteins E1-E2 Alphavirises on Earth and in Space (Glykoproteid-K) - 08.05.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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The following content was provided by K. A. Miroshnikov, G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
K. A. Miroshnikov, Shubnikiv Institut of Crystallograhy of Russian Academy of Sciences (IC RAS), Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
April 2005 - October 2008

Expeditions Assigned
11,13,16,17

Previous ISS Missions
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Experiment Description

Research Overview
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Description
Acquisition of data on an atomic structure of biomolecules of glycoproteins E1-E2 of the maximum high resolution to produce effective and safe vaccines of a new generation and develop new antiviral preparations and diagnostic systems.

Test of the crystallization process, production of crystals of glycoproteins E1-E2 analogs of alpha viruses in microgravity conditions to make the subseauent ground roentgenodiffraction analysis.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements
Kriogem-03M Refrigerator to maintain proper temperature while onboard, Reusable Heat-insulated container with cold accumulator TVK-M, Maintain proper temperature while returning the crystals to the Earth, CPCF Module to grow the protein crystals in orbit and deliver to Earth, Activation Device to activate crystal growth process.

Operational Protocols
Obtain crystals of alpha-virus E1-E2 glicoproteins analogs.

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Results/More Information

Universal biocrystallization cassettes and experiment footage returned to the Earth.

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Results Publications

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Ground Based Results Publications

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ISS Patents

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Related Publications

    Tsygannik IN, Artemyev IV, Arkhipova SF, Pletnyev VZ, Scherbakov GY.  Crystallization of proteins in microgravity  . Scientific and Technical Conference on the Main Results of Applied Scientific Research on the ISS RS, Korolev, Russia; 2007

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Kriogem-03M Refridgerator maintains proper temperature onboard. Reusable heat-insulated container with cold accumulator TVK-M maintains proper temperature while returning the crystals to the Earth. CPCF Module grows the protein crystals in the orbit and delivery to the Earth. Activation Device activates crystal growth process.
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