Fluid and Electrolyte Metabolism and Hormonal Regulaltion of Fluid Volume (Diurez (Diuresis)) - 02.25.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Objectives for Everyone
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Science Results for Everyone
Electrolytes (ie. sodium and potassium)affect the amount of water in our body fluids as well as muscle function and other important processes. This experiment evaluated how metabolism of electrolytes changes in microgravity. Data showed that younger crew members tend to have a lower body mass index and more muscular crew members show an increased blood concentration of potassium. Data also showed changes in hormones involved in signaling in the central nervous system. Such changes could affect blood pressure, cardiac output, and balance in long-term flight. These factors will be useful in evaluating nutritional status and physical and mental activities of crewmembers during and after flight. 

The following content was provided by Irina M. Larina, and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)

  • Irina M. Larina, Institute for Biomedical Problems, Moscow, Russia

  • Co-Investigator(s)/Collaborator(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    August 2001 - April 2005

    Expeditions Assigned

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Reception of new data on the water-salt metabolism status and hormonal control of volimia in zero-gravity conditions and during post-flight readaptation period.

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    Space Applications
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    Earth Applications
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    Operational Requirements
    Plasma-03 centrifuge to separate blood into plasma and serum, Plasma-03 set of accessories for sampling, Gematokrit Kit to take blood samples and separate plasma from erythrocytes defining hematocrit number, Reflotron-4 Kit capillary blood count for hemoglobin, creatinine and urea, KV-03 Container, Plasma-03 Kit for taking, processing and storage of venous blood and urine, M-Priemniki Kit to study water-salt metabolism, Cryogem-03 refrigerator to freeze blood samples.

    Operational Protocols
    Study of the dependence between renal elimination activity and its hormonal control. Study of the balance of liquid and main electrolytes.

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    Results/More Information

    Evaluation of mechanisms of water-electrolyte metabolism adaptation to zero-gravity conditions.

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    Results Publications

      Morukov BV, Nichiporuk IA, Tret'yakov VS, Larina IM.  Biochemical Markers of Bone Tissue Metabolism in Cosmonauts After a Prolonged Spaceflight. Human Physiology. 2005; 31(6): 684-687. DOI: 10.1007/s10747-005-0115-z.

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    image Plasma-03 kit.
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