Examination of the Influencing Factors of Space Flight on Autonomic Regulation of Blood Circulation, Respiration and Cardiac Contractile Function in Long Duration Space Flight (Pnevmocard (Pneumocard)) - 04.10.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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Science Objectives for Everyone Pneumocard is an integrated study of the adaptation of the cardiovascular system of crewmembers during a long-duration microgravity mission.

Science Results for Everyone
Information Pending



This content was provided by Roman M. Baevsky, M.D., and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom

Principal Investigator(s)

  • Roman M. Baevsky, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Moscow, Russia

  • Co-Investigator(s)/Collaborator(s)
    Information Pending
    Developer(s)
    Information Pending
    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
    Information Pending

    ISS Expedition Duration
    April 2008 - March 2013

    Expeditions Assigned
    17,18,19/20,21/22,23/24,25/26,27/28,29/30,31/32,33/34

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview
    Information Pending

    Description
    Acquiring new scientific information to refine the understanding about the mechanisms of adapting the cardiorespiratory system and the whole organism to space flight conditions. Integrated study of a cardiovascular system of astronauts in various phases of a long-duration mission in order to clarify the adaptation mechanisms and phases and determine diagnostic criteria for individual assessment of the organism adaptation to zero-gravity conditions. Study of the synchronization of heart activity and breathing factors, as well as the cardiorespiratory system control processes based on variability rate of physiological parameters. Study of interconnection between the cardiorespiratory system during a long-duration mission and tolerance of orthostatic and physical activities at the beginning of readaptation for predicting possible reactions of the crewmembers organism during the their return to ground.

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    Applications

    Space Applications
    Information Pending

    Earth Applications
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    Operations

    Operational Requirements
    Four kits with ten seeds Astronium fraxinifolium in each are used in the experiment. Two kits shall be exposed in the light, the rest shall be exposed in the dark. The seeds germinate at the temperatures from +20 to +30 degrees C and at a low concentration of oxygen (3%). Activation of the germination process is performed through seeds wetting using the enclosed syringe with water. To determine the germination rate and germ phenotype, photography by onboard camera is used. Laptop is used for the following processing of digital photos and their preparation for downlink.

    Operational Protocols
    The following physiological data will be recorded during the experiment: Electrocardiogram; Impedance cardiogram; Low-frequency phonocardiogram (seismocardiogram); Pneumotachogram (using nose temperature sensors) Finger photopletismogram. All physiological data will be recorded on the PCMCIA card, which will be downloaded upon completion of the increment.

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    Results/More Information
    Cognitive Cardiovascular Experiment (Cardiocog-2) heart rate variability (HRV) was measured and analyzed on 14 Russian cosmonauts during long term space flights (twice before and after flight, monthly in flight) to test the hypothesis that HRV can be used to provide important information for crew health monitoring. Changes of blood pressure (BP) and heart rate (HR) seen in cosmonauts during space flight may be relatively small when compared to patients with cardiovascular diseases. However, these small changes are the result of compensatory changes of the regulatory systems, and measurements of cardiovascular and respiratory control may provide useful health information. Results suggest that the HRV of cosmonauts remained relatively stable during the six months in space with the most pronounced change occurring after landing. Interestingly, the functional state assessed by HRV improved during space flight if compared to preflight and early postflight data. In some instances, a shift from the physiological normal state to the altered functional state during space flight was also detected, and analysis of individual cosmonauts showed distinct patterns depending on the preflight status. The most pronounced changes were detected early after landing (1?3 days) but returned to preflight values at 5?7 days after landing in most cosmonauts. The key finding of the study was that the classification system based on analysis of HRV data to calculate a functional state of the cosmonaut before, during, and after space flight may be used to show individual adaptation to microgravity. The monthly measurements during space flight allowed detection of any likely trend toward a lower functional state and potential cardiovascular impairment at the end of flight (Baevsky et al., 2007, 2011).

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    Results Publications

      Baevsky RM, Chernikova AG, Funtova II, Tank J.  Assessment of individual adaptation to microgravity during long term space flight based on stepwise discriminant analysis of heart rate variability parameters. Acta Astronautica. 2011; 69: 1148-1152. DOI: 10.1016/j.actaastro.2011.07.011.
      Funtova II, Luchitskaya ES, Slepchenkova IN, Tank J, Baevsky RM.  Comparative assessment of the results of day and night studies of cardiac rhythm variability on board the International Space Station.
      5th All-Russian Conference on Analyzing Heart Rate Variability, Izhevsk, Russia
      ; 2011 October 26-28
      Baevsky RM, Funtova II, Diedrich A, Pashchenko AV, Chernikova AG, Drescher J, Baranov VM, Tank J.  Autonomic Function Testing on Board the ISS - update on "Pneumocard". Acta Astronautica. 2007; 61(7-8): 672-675. [Also: Baevsky R.M, Funtova I.I., Diedrich A., Chernikova A.G., Tank J. Autonomic function testing aboard the ISS using "PNEUMOCARD". 58-th Congress IAA, Hyderabad, India, September, 2007]
      Baevsky RM, Baranov VM, Bogomolov VV.  Prospects of  development of the medical control automated systems at the ISS on the basis of onboard equipment “Puls”and “Pneumocard” using. 54th International Astronautical Congress, Bremen, Germany; 2003 September 29 - October 3
      Funtova II, Baevsky RM, Luchitskaya ES, Slepchenkova IN, Drescher J, Tank J.  Day- vs. night time heart rate variability changes in microgravity: experiments "Pneumocard" and "Sonocard". 62nd International Astronautical Congress, Cape Town, South Africa; 2011
      Baranov VM, Baevsky RM, Drescher J, Tank J.  Investigations of the cardiovascular and respiratory systems on board the international space station: experiments PULS and PNEUMOCARD. 53rd International Astronautical Congress, The World Space Congress, Houston, TX; 2002 October 10-19
      Baevsky RM, Funtova II, Diedrich A, Pashenko AV, Chernikova AG, Drescher J, Baranov VM, Tank J.  Autonomic function testing on board the ISS – update on Pneumocard. 56th International Astronautical Congress, Fukuoka, Japan; 2005 Octover 16-21 15-20.
      Funtova II, Chernikova AG, Baevsky RM.  Assessment of individual adaptation to microgravity during long term space flight based  on stepwise discriminant analysis of heart rate variability parameters.
      17th IAA Humans in Space Symposium, Moscow, Russia
      ; 2009
      Baevsky RM, Baranov VM, Funtova II, Diedrich A, Pashenko AV, Chernikova AG, Drescher J, Jordan J, Tank J.  Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station. Journal of Applied Physiology. 2007 July; 103(1): 156-161. DOI: 10.1152/japplphysiol.00137.2007.
      Chernikova AG, Baevsky RM, Funtova II.  The probability approach to an estimation of risk of a pathology at cosmonauts according to analysis HRV.
      14th Congress of the International Society for Holter and Noninvasive Electrocardiology, Moscow, Russia  
      ; 2011 April
      Eshmanova AK, Luchitskaya ES.  Study of cardiac rhythm variability during 7-day exposure to “dry” immersion.
      5th All-Russian Conference on Analyzing Heart Rate Variability, Izhevsk, Russia
      ; 2011 October 26-28
      Baevsky RM, Okhritsky AA, Pashchenko AV, Prilutsky DA, Funtova II.  Medical polygraph software for scientific research.
      Meditsinskaia Tekhnika (Biomedical Engineering)
      . 2007; 1: 19-24.
      Baevsky RM, Bersenev YY, Luchitskaya ES, Funtova II, Chernikova AG.  Studies of the vegetative regulation of the cardiovascular system in long-term weightlessness.
      Space Forum 2011 Dedicated on 50th Anniversary fo Yu. A. Gagarin Flight, Moscow, Russia
      ; 2011 October
      Baevsky RM, Funtova II, Tank J.  Research experiment "Pneumocard" onboard the International space station.
      14th Congress of the International Society for Holter and Noninvasive Electrocardiology, Moscow, Russia  
      ; 2011 April
      Luchitskaya ES, Chernikova AG, Funtova II, Baevsky RM.  Analysis of cardiac rhythm variability in space medicine. Results of studies on the International Space Station.
      4th Russian National Congress on Clinical Electrocardiology, Velikiy Novgorod, Russia
      ; 2010 April 28-29 62-63.
      Baevsky RM, Luchitskaya ES, Funtova II, Chernikova AG.  Study of the autonomic regulation of blood circulation during a long-term space flight. Human Physiology. 2013 October 11; 39(5): 486-495. DOI: 10.1134/S0362119713050046.
      Funtova II, Chernikova AG, Fedorova IN, Baranov VM, Tank J, Baevsky RM.  Some results of scientific experiment “Pneumocard” aboard the International space station.
      17th IAA Humans in Space Symposium, Moscow, Russia
      ; 2009

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    Ground Based Results Publications

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    ISS Patents

      Baranov VM, Baevsky RM, Pashchenko AV, Shmelev SI.  Mobile device for comprehensively examining the cardio-respiratory system of cosmonauts.
      Federal Service for Intellectual Property
      .58886. December 10 2006.
      Baevsky RM, Baranov VM, Bersenev YY, Funtova II, Semyonov YN, Grigoriev AI, Prilutsky DA.  Method of determining functional reserves for regulating the human cardio-respiratory system.
      Federal Service for Intellectual Property
      .2240035. November 20 2004.

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    Related Publications

      Slepchenkova IN, Luchitskaya ES.  Use of the Sonocard and Pneumocard onboard complexes in a 105-Day experiment for the MARS-500 Project.
      4th European Congress Medicine in Space and in Extreme Environments Achievements for Health Care on Earth, Berlin, Germany
      ; 2010

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    Related Websites
    Coordinating Scientific and Technical Council of the Russian Space Agency [Russian]
    Energia - Science Research on the ISS Russian Segment

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    Imagery