Morphofunctional Characteristic of Blood Cells and the Intensity of Erythropoiesis in Humans by the Influence of Factors of Space Flight (Gematologia (Haematology)) - 02.25.15

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Erythropoiesis is the production of new red blood cells and removal of old ones. This investigation examined that process to determine the ideal level of red blood cells astronauts need to readapt to terrestrial gravity. Results confirmed that the anemia astronauts often experience in space is caused by many factors in addition to decreased red blood cell production. Those factors may include ineffective erythropoiesis, cell metabolism changes, and premature removal of red blood cells from the bloodstream. The data will support future diagnosis and treatment of space anemia and related conditions in spaceflight and blood system conditions on Earth.

The following content was provided by S M. Ivanova, and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)

  • S M. Ivanova, Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Russia

  • Co-Investigator(s)/Collaborator(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    April 2004 - September 2006

    Expeditions Assigned

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Deriving new data on the space flight factors impact on the human blood system to extend diagnostic and prognostic capabilities of detecting mechanisms of arising shifts in hematologic indices ("space anemia", lymphocytosis).

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    Space Applications
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    Earth Applications
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    Operational Requirements
    Samples of venous blood in KV-03 container; Eritrotsit' kit with fingertip blood samples; Data on hemoglobin content transmitted via radio links; The logbook sheets with crew members' records.

    Operational Protocols
    Collecting samples of venous and capillary blood with the aim: to study erythrocyte forms; to investigate metabolism of erythrocytes, cell membrane conditions, indices of ferrum metabolism and erythropoetin content in blood.

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    Results/More Information

    The findings will allow to detect mechanisms of the blood system adaptation to space flight factors, to extend the system of diagnostic and prognostic criteria for assessment of human physical state under extreme effects, as well as they can be used to develop prophylactic and pharmacologic preparations to treat disturbances in the blood system in these conditions.

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    Results Publications

      Ivanova SM, Brazhe NA, Luneva OG, Yarlikova YV, Labetskaya OI, Parshina EY, Baizhumanov AA, Maksimov GV, Morukov BV.  Physical-chemical Properties of Plasma Membrane and Function of Erythrocytes of Cosmonauts After Long-term Space Flight. Acta Astronautica. 2011; 68: 1517-1522. DOI: 10.1016/j.actaastro.2010.06.046.

      Grigoriev AI, Ivanova SM, Morukov BV, Maksimov GV.  Development of Cell Hypoxia Induced by Factors of Long-term Spaceflight. Doklady Biochemistry and Biophysics. 2008; 422: 308-311. DOI: 10.1134/S1607672908050141. PMID: 19024564.

      Grigoriev AI, Ivanova SM, Morukov BV, Maksimov GV.  Onset of Cellular Hypoxia During Long-Term Spaceflight. Reports of the Academy of Sciences: Biochemistry, Biophysics, Molecular Biology. 2008; 422(6): 823-826.

      Ivanova SM, Morukov BV, Labetskaya OI, Yarlikova YV, Levina AA, Kozinets GI.  Morphobiochemical research on the red blood cell system in primary crewmembers on the International Space Station. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2006; 40(3): 9-16.

      Ivanova SM, Morukov BV, Labetskaya OI, Yarlikova YV, Levina AA, Shishkanova ZG.  Red Blood of Cosmonauts During Missions Aboard the International Space Station (ISS). Human Physiology. 2004; 11(2): 79-80.

      Morukov BV, Ivanova SM, Maksimov GV, Yarlikova YV, Labetskaya OI, Luneva OG, Maksimova NV, Brazhe NA, Bryzgalova NY, Parshina EY, Nemirovskaya TL.  Investigation of the fluidity and permeability of human erythrocyte plasma membrane and the efficacy of oxygen transfer by hemoglobin during rehabilitation period after space flight. Journal of Gravitational Physiology. 2006; 13(1): 139-141.

      Ivanova SM, Maksimov GV, Morukov BV, Yarlikova YV, Labetskaya OI, Luneva OG, Maksimova NV, Brazhe NA, Bryzgalova NY, Parshina EY.  Role of the Elasticity and Permeability of the Plasma Membrane of Erythrocytes in Regulating the Effectiveness of Hemoglobin Oxygen Transport in Humans after Completion of a Spaceflight. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2007; 41(2): 41-44.

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    image Plasma-03 centrifuge for blood separation into serum and plasma. Image courtesy of Russian Space Agency (Energia Website).
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