Morphofunctional Characteristic of Blood Cells and the Intensity of Erythropoiesis in Humans by the Influence of Factors of Space Flight (Gematologia (Haematology)) - 12.03.13
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Russian Federal Space Agency (Roscosmos)Sponsoring Organization
Information PendingResearch Benefits
Information PendingISS Expedition Duration:
April 2004 - September 2006Expeditions Assigned
9,10,11,12,13Previous ISS Missions
Deriving new data on the space flight factors impact on the human blood system to extend diagnostic and prognostic capabilities of detecting mechanisms of arising shifts in hematologic indices ("space anemia", lymphocytosis).
Information PendingEarth Applications
Samples of venous blood in KV-03 container; Eritrotsit' kit with fingertip blood samples; Data on hemoglobin content transmitted via radio links; The logbook sheets with crew members' records.Operational Protocols
Collecting samples of venous and capillary blood with the aim: to study erythrocyte forms; to investigate metabolism of erythrocytes, cell membrane conditions, indices of ferrum metabolism and erythropoetin content in blood.
The findings will allow to detect mechanisms of the blood system adaptation to space flight factors, to extend the system of diagnostic and prognostic criteria for assessment of human physical state under extreme effects, as well as they can be used to develop prophylactic and pharmacologic preparations to treat disturbances in the blood system in these conditions.
Ivanova SM, Brazhe NA, Luneva OG, Yarlikova YV, Labetskaya OI, Parshina EY, Baizhumanov AA, Maksimov GV, Morukov BV.Physical-chemical Properties of Plasma Membrane and Function of Erythrocytes of Cosmonauts After Long-term Space Flight. Acta Astronautica. 2011; 68: 1517-1522.
Grigoriev AI, Ivanova SM, Morukov BV, Maksimov GV.Development of Cell Hypoxia Induced by Factors of Long-term Spaceflight. Doklady Biochemistry and Biophysics. 2008; 422: 308-311. DOI: 10.1134/S1607672908050141. PMID: 19024564.
Grigoriev AI, Ivanova SM, Morukov BV, Maksimov GV. Onset of Cellular Hypoxia During Long-Term Spaceflight.Reports of the Academy of Sciences: Biochemistry, Biophysics, Molecular Biology. 2008; 422(6): 823-826.
Ivanova SM, Morukov BV, Labetskaya OI, Yarlikova YV, Levina AA, Kozinets GI. Morphobiochemical research on the red blood cell system in primary crewmembers on the International Space Station.Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2006; 40(3): 9-16.
Ivanova SM, Morukov BV, Labetskaya OI, Yarlikova YV, Levina AA, Shishkanova ZG. Red Blood of Cosmonauts During Missions Aboard the International Space Station (ISS). Human Physiology. 2004; 11(2): 79-80.
Morukov BV, Ivanova SM, Maksimov GV, Yarlikova YV, Labetskaya OI, Luneva OG, Maksimova NV, Brazhe NA, Bryzgalova NY, Parshina EY, Nemirovskaya TL. Investigation of the fluidity and permeability of human erythrocyte plasma membrane and the efficacy of oxygen transfer by hemoglobin during rehabilitation period after space flight. Journal of Gravitational Physiology. 2006; 13(1): 139-141.
Ivanova SM, Maksimov GV, Morukov BV, Yarlikova YV, Labetskaya OI, Luneva OG, Maksimova NV, Brazhe NA, Bryzgalova NY, Parshina EY. Role of the Elasticity and Permeability of the Plasma Membrane of Erythrocytes in Regulating the Effectiveness of Hemoglobin Oxygen Transport in Humans after Completion of a Spaceflight.Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2007; 41(2): 41-44.
Ground Based Results Publications
Plasma-03 centrifuge for blood separation into serum and plasma. Image courtesy of Russian Space Agency (Energia Website).
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