Optimization of Heterological Expresssion in Yeasts-True Yeasts in Microgravity for Example Synthesis of the HBS Antigen of the Virus Hepatitis B (Antigen (Antigene)) - 08.20.14
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
ISS Expedition Duration
April 2006 - April 2009
Previous ISS Missions
Compare specifics of heterologous expression of HbsAg gen of hepatitis B virus in yeasts S.cerevisiae under microgravity and gravity conditions and establish synthesis optimization techniques.
Container, Vial with an ampoule with lyophilized cultures, Tube with biosample vials, Temperature data logger.
Produce a clone collection of producer strain with heritable deviations in HbsAg gen expression level. Perform a genetic analysis and restriction mapping of plasmids and mutant clones.
Obtaining maximum complete potential characteristics of heterologous expression of HbsAg gen of hepatitis B virus in yeasts S.cerevisiae. Thereafter new principles of increasing producers? efficiency will be developed.
Coordinating Scientific and Technical Council of the Russian Space Agency [Russian]
Energia - Science Research on the ISS Russian Segment