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Optimization of Heterological Expresssion in Yeasts-True Yeasts in Microgravity for Example Synthesis of the HBS Antigen of the Virus Hepatitis B (Antigen)
04.26.13

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Overview | Description | Applications | Operations | Results | Publications | Imagery

Experiment Overview

This content was provided by L. A. Nesterova, and is maintained in a database by the ISS Program Science Office.

Brief Summary

Information Pending

Principal Investigator(s)

  • L. A. Nesterova, Russia

    • Co-Investigator(s)/Collaborator(s)

    Information Pending

    Developer(s)
    Information Pending

    Sponsoring Space Agency

    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization

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    Research Benefits

    Information Pending

    ISS Expedition Duration:

    April 2006 - April 2009

    Expeditions Assigned

    13,14,15,16,17,18

    Previous ISS Missions

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    Experiment Description

    Research Overview

    Information Pending

    Description

    Compare specifics of heterologous expression of HbsAg gen of hepatitis B virus in yeasts S.cerevisiae under microgravity and gravity conditions and establish synthesis optimization techniques.

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    Applications

    Space Applications

    Information Pending

    Earth Applications

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    Operations

    Operational Requirements

    Container, Vial with an ampoule with lyophilized cultures, Tube with biosample vials, Temperature data logger.

    Operational Protocols

    Produce a clone collection of producer strain with heritable deviations in HbsAg gen expression level. Perform a genetic analysis and restriction mapping of plasmids and mutant clones.

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    Results/More Information

    Obtaining maximum complete potential characteristics of heterologous expression of HbsAg gen of hepatitis B virus in yeasts S.cerevisiae. Thereafter new principles of increasing producers? efficiency will be developed.

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    Related Websites
  • Coordinating Scientific and Technical Council of the Russian Space Agency [Russian]
  • Energia - Science Research on the ISS Russian Segment

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    Imagery

    Information provided by the investigation team to the ISS Program Scientist's Office.
    If updates are needed to the summary please contact JSC-ISS-Program-Science-Group. For other general questions regarding space station research and technology, please feel free to call our help line at 281-244-6187 or e-mail at JSC-ISS-Research-Helpline.
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