Vegatative (Autonomic) Regulation of the Cardio-Respiratory System of Humans in Conditions of Weightlessness (Puls (Pulse)) - 05.13.15
MBI-9 (Pulse) is a cardiological assessment which collects data on arterial blood pressure and an electrocardiogram is performed to better understand the effects of weightlessness on the human cardiorespiratory system. Science Results for Everyone
This investigation of microgravity’s effect on human cardiorespiratory systems showed that stress is an important factor. The body can maintain high performance for a time, but the resulting increased stress affects the cardiovascular system. Stress therefore needs to be monitored during flight as a risk factor for health issues. Researchers also discovered a direct link between an individual’s autonomic or involuntary regulation of heart and respiratory rate and adaptation to weightlessness, making it possible to predict how crew members will adapt during flight. Evaluation of changes in autonomic regulation will also be useful for medical monitoring, since those changes predict disruptions in the affected organs. Experiment Details
Roman M. Baevsky, M.D., Institute of Medical and Biological Problems of Russian Academy of Sciences (IMBP RAS), Moscow, Russia
Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
ISS Expedition Duration
June 2002 - September 2006
Previous ISS Missions
Acquisition of new scientific information to extend ideas about mechanisms of cardio-respiratory system adaptation to long-duration space flights.
Pulse Kit, Laptop, Pulse Pouch.
Study of impact of long-duration space flight factors on the functional state of cardiovascular and respiratory systems of cosmonauts by using computer modifications of electrocardiography, sphygmography and pneumotachography. Study of control processes for the cardiorespiratory system. Control of cardioresparatory homeostasis indices (average pulse rate, cardiac output and stroke volume, phase structure of the cardiac cycle, systole efficiency, average respiration rate, volumetric and rate characteristics of the expired air). Control of indices of the control system of the cardiorespiratory system.
Improvement of the cosmonauts' medical supervision system in a long-duration flight. Development of new criteria for prognostic assessment of probable violations of cardiorespiratory homeostasis.^ back to top
Baevsky RM, Pashchenko AV, Funtova II, Chernikova AG. Study of Vegetative Regulation of the Cardiovascular System in Long-Term Spaceflights on the International Space Station. Computerized Medicine Applied Science Conference. Kharkov, Ukraine; 2005 Jun 23-25
Baranov VM, Baevsky RM, Pashchenko AV, Funtova II, Chernikova AG, Drescher J, Tank J. Autonomous regulation of cardiovascular system in cosmonauts and prospects of researches on ISS. 57th International Astronautical Congress, Valencia, Spain; 2006 Oct 2-6
Baevsky RM, Funtova II. Analysis of Cardiac Rhythm Variability in Experiments on Board the International Space Station. All-Russian Symposium on the Variability of Cardiac Rhythm: Theoretical Aspects and Practical Application, Izhevsk, Russia; 2003 Nov
Baevsky RM, Chernikova AG. Heart rate variability analysis in evaluation of functional state in humans during long-term space flight. 14th Man in Space Symposium. Banff, Alberta, Canada; 2003 May
Baevsky RM, Baranov VM, Bogomolov VV. Experiments "Pulse" and "Pneumocard" aboard the International Space Station. The prospects for development of an automated medical monitoring system. 54th International Astronautical Congress, Bremen, Germany; 2003 September 29 - October 3
Baranov VM, Baevsky RM, Drescher J, Tank J. Investigations of the cardiovascular and respiratory systems on board the international space station: experiments PULS and PNEUMOCARD. 53rd International Astronautical Congress, The World Space Congress, Houston, TX; 2002 October 10-19
Baevsky RM, Baranov VM, Funtova II, Diedrich A, Pashenko AV, Chernikova AG, Drescher J, Jordan J, Tank J. Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station. Journal of Applied Physiology. 2007 July; 103(1): 156-161. DOI: 10.1152/japplphysiol.00137.2007. PMID: 17446414.
Chernikova AG, Baevsky RM, Nikulina GA, Funtova II. Analysis of Cardiac Rhythm Variability in Assessing Human Functional Status During Spaceflight. 19th Congress of the I.P. Pavlov Physiological Society; 2004
Chernikova AG, Baevsky RM. Mathematical Models of Functional Status Based on Analysis of Cardiac Rhythm Variability. All-Russian Symposium on the Variability of Cardiac Rhythm: Theoretical Aspects and Practical Application, Izhevsk, Russia; 2004 Sep
Baevsky RM, Funtova II, Chernikova AG. Principles of Creating a Medical Expert System for Evaluating Prenosological Statuses in Long-Term Spaceflights. Computerized Medicine Applied Science Conference. Kharkov, Ukraine; 2007 Sep 14-15
Tank J, Baevsky RM, Drescher J, Funtova II. Impact of cardiovascular research on board the International Space Station on the design of new medical devices. 2nd European Medical and Biological Engineering Conference (EMBEC). Vienna, Austria.; 2002 Dec 4-8
Chernikova AG. Mathematical Modeling of the Space of Functional Statuses Using Data from the Analysis of Cardiac Rhythm Variability. The Body and Environment: Adaptation to Extreme Conditions. Moscow, Russia; 2003 374-376.
Tank J, Chernikova AG, Baevsky RM. Types of regulation and adaptation reactions in space flights. 5th Symposium of Autonomic Regulation, Lisbon, Portugal ; 2006 May 25-29
Pashchenko AV, Baevsky RM. New method for orthostatic test evaluation based on heart rate variability. Proceedings of the European Study Group on Cardiovascular Oscillations. Jena, Germany; 2006 May 15-17 78-81.
Baevsky RM, Okhritsky AA, Pashchenko AV, Prilutsky DA, Funtova II. Medical polygraph software for scientific research. Meditsinskaia Tekhnika (Biomedical Engineering). 2007; 1: 19-24.
Baevsky RM. Theoretical and Applied Aspects of Controlling Adaptive Processes in Long-Term Spaceflight Conditions. The Body and Environment: Adaptation to Extreme Conditions. Moscow, Russia; 2003 24-26.
Baevsky RM, Baranov VM, Chernikova AG, Funtova II, Pashchenko AV, Tank J. Heart rate variability as indicator of cardioregulatory system. Experiment result of ISS. Proceedings of the European Study Group on Cardiovascular Oscillations. Jena, Germany; 2006 May 15-17 74-77.
Baevsky RM, Luchitskaya ES, Funtova II, Chernikova AG. Study of the autonomic regulation of blood circulation during a long-term space flight. Human Physiology. 2013 October 11; 39(5): 486-495. DOI: 10.1134/S0362119713050046.
Baevsky RM, Chernikova AG, Funtova II. Assessment of Functional Status and Type of Regulation of the Circulatory System in Spaceflight Conditions Using Data for the Analysis of Cardiac Rhythm Variability. 7th Applied Science Conference on Diagnosis and Treatment of Disruptions to the Regulation of the Cardiovascular System. Moscow, Russia; 2005 Mar 23 310-318.
Ground Based Results Publications
Baevsky RM. A System for Evaluating and Predicting the State of Health of Cosmonauts, and Prospects for its Development. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2001; 2: 36-45.
Baevsky RM, Bersenev YY, Drescher J. Computer Systems for Studying Circulation and Respiration on Board the International Space Station. Materials of the 12th Conference on Space Biology and Aerospace Medicine; 2002 38-39.
Baevsky RM, Nikulina GA, Funtova II, Chernikova AG. Vegetative Regulation of Circulation. Orbital Station Mir. 2000; 2: 36-68.
Baevsky RM, Chernikova AG. On the Problem of Physiological Norms: a Mathematical Model of Functional Status Based on Analysis of Variability of cardiac Rhythm. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2002; 5: 34-37.
Tank J, Baevsky RM, Berseneva AP. Рrospects for development of novel research apparatuses for the international Space Station based on the experience of clinical and physiological investigations of the circulation regulating mechanisms. Symposium on the Achievements of Space Medicine in the Practice of Health Care and Industry. Berlin, Germany; 2001 164-176.
Baevsky RM. Predicting Conditions on the Line Between the Norm and Pathology. Meditsina. 1979: 225.
Energia - Science Research on the ISS Russian Segment
The Pulse Kit.
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