Kristallizator (Crystallizer) allows the growth of large protein crystals in orbit and allows better determination of the 3-dimensional structure of the crystals with applications in applied biology, medicine, and pharmacology. It is operated in the CRYOGEM-03 cooler.Principal Investigator(s)
Russian Federal Space Agency (Roscosmos)Sponsoring Organization
Information PendingResearch Benefits
Information PendingISS Expedition Duration:
October 2005 - September 2011Expeditions Assigned
12,13,14,15,16,18,21/22,25/26,27/28Previous ISS Missions
Study of physical processes of protein crystallization to produce the protein monocrystals perfect in structure suitable for X-ray structure analysis.
Study of biocrystal films of volumetric solution on substrates using the artificial epitaxy effect.
Development of the new generation hardware and techniques to crystallize a large amount of proteins in the interests of basic and applied biology, medicine, pharmacology and microelectronics.
Information PendingEarth Applications
Module-1 is a device to grow the protein monocrystals. Module-3 is a device to grow bidimensional oriented films using the artificial epitaxy effect.Operational Protocols
Test techniques in microgravity conditions to produce monocrystals of biological macromolecules and orient film-forming crystallites. Test the hardware, modes and conditions to grow the protein monocrystals and biological films. Estimate efficiency and reliability of the used hardware. Test the experiment timeline to organize the small-batch growing of biocrystals and films in microgravity conditions.
Biocrystallization modules with the experiment results transported safely back to Earth for analysis, along with a log sheet with data of the experiment timeline. Also, the daily telemetry information of the air temperature in the accommodation area of biocrystallizers must be sent.
Givargizov E, Grebenko AI, Zadorozhnaya LA, Melik-Adamyan VR. Growth of biocrystalline films of PVC catalase in space using artificial epitaxy (graphoepitaxy). Journal of Crystal Growth. 2008; 310: 847-852. DOI: 10.1016/j.jcrysgro.2007.11.166.