Intercellular Interactions in Space Flight (Mezhkletochnoe Vzaimodeistvie) - 02.25.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Objectives for Everyone
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Science Results for Everyone
Because there’s no time for sick days in space, much research on the space station concerns immune system function. Previous studies have found that, in isolated cultures of mononuclear cells, communication is disrupted between T-cells (a type of white blood cell formed in the thymus gland that defends the organism from invaders) and helper cells (so named because they help other white blood cells mature or activate). This disruption inhibits T-cell activity and, therefore, immune response.  But this investigation showed that microgravity is not the culprit, as it did not disturb function of cultured immune cells during 24-hour incubation with specific targets.

The following content was provided by Lyudmila B. Buravkova, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)

  • Lyudmila B. Buravkova, Institute for Biomedical Problems, Moscow, Russia

  • Co-Investigator(s)/Collaborator(s)
    Information Pending

    Developer(s)
    Information Pending

    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    October 2004 - April 2006

    Expeditions Assigned
    10,11,12

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview
    Information Pending

    Description
    Assessment of cytotoxic activity of isolated human blood lymphocytes during the combined cultivation with cell culture K-562 under microgravity conditions.

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    Applications

    Space Applications
    Information Pending

    Earth Applications
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    Operations

    Operational Requirements
    Fibroplast stowage, Thermostatically controlled container Akvarius for conducting the cultivation process, Glove box.

    Operational Protocols
    Grow blood cultures in microgravity environment to return to earth for study.

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    Results/More Information

    The research conducted allows to develop the methods for analyzing immunity system condition directly onboard the orbital space station.

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    Results Publications

      Buravkova LB, Grigorieva OV, Rykova MP.  The effect of microgravity on the in vitro NK cell function during six International Space Station Missions. Microgravity Science and Technology. 2007; 19(5-6): 145-147. DOI: 10.1007/BF02919470.

      Rykova MP, Gertsik YG, Antropova EN, Buravkova LB.  Serum levels of immunoglobulins, allergen-specific IgE antibodies, and interleukin-4 in cosmonauts before and after short flights on the International Space Station. Human Physiology. 2006; 32(4): 457-460. DOI: 10.1134/S0362119706040128.

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    Imagery

    image The Intercellular Interaction experiment kit.
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    image Glove Box.
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