Intercellular Interactions in Space Flight (Mezhkletochnoe Vzaimodeistvie) - 07.14.16
Information Pending Science Results for Everyone
Because there’s no time for sick days in space, much research on the space station concerns immune system function. Previous studies have found that, in isolated cultures of mononuclear cells, communication is disrupted between T-cells (a type of white blood cell formed in the thymus gland that defends the organism from invaders) and helper cells (so named because they help other white blood cells mature or activate). This disruption inhibits T-cell activity and, therefore, immune response. But this investigation showed that microgravity is not the culprit, as it did not disturb function of cultured immune cells during 24-hour incubation with specific targets. Experiment Details
Lyudmila B. Buravkova, Institute for Biomedical Problems, Moscow, Russia
Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)
ISS Expedition Duration
October 2004 - April 2006
Assessment of cytotoxic activity of isolated human blood lymphocytes during the combined cultivation with cell culture K-562 under microgravity conditions.
Operational Requirements and Protocols
Fibroplast stowage, Thermostatically controlled container Akvarius for conducting the cultivation process, Glove box.
Grow blood cultures in microgravity environment to return to earth for study.
Decadal Survey Recommendations
Information Pending^ back to top
The research conducted allows to develop the methods for analyzing immunity system condition directly onboard the orbital space station.^ back to top
Buravkova LB, Grigorieva OV, Rykova MP. The effect of microgravity on the in vitro NK cell function during six International Space Station Missions. Microgravity Science and Technology. 2007; 19(5-6): 145-147. DOI: 10.1007/BF02919470.
Rykova MP, Gertsik YG, Antropova EN, Buravkova LB. Serum levels of immunoglobulins, allergen-specific IgE antibodies, and interleukin-4 in cosmonauts before and after short flights on the International Space Station. Human Physiology. 2006; 32(4): 457-460. DOI: 10.1134/S0362119706040128.
Ground Based Results Publications
Energia - Science Research on the ISS Russian Segment
The Intercellular Interaction experiment kit.
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