Intercellular Interactions in Space Flight (Mezhkletochnoe Vzaimodeistvie) - 08.05.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
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Science Results for Everyone
Because there’s no time for sick days in space, much research on the space station concerns immune system function. Previous studies have found that, in isolated cultures of mononuclear cells, communication is disrupted between T-cells (a type of white blood cell formed in the thymus gland that defends the organism from invaders) and helper cells (so named because they help other white blood cells mature or activate). This disruption inhibits T-cell activity and, therefore, immune response.  But this investigation showed that microgravity is not the culprit, as it did not disturb function of cultured immune cells during 24-hour incubation with specific targets.

The following content was provided by Lyudmila B. Buravkova, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
Lyudmila B. Buravkova, Institute for Biomedical Problems, Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
October 2004 - April 2006

Expeditions Assigned
10,11,12

Previous ISS Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
Assessment of cytotoxic activity of isolated human blood lymphocytes during the combined cultivation with cell culture K-562 under microgravity conditions.

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Applications

Space Applications
Information Pending

Earth Applications
Information Pending

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Operations

Operational Requirements
Fibroplast stowage, Thermostatically controlled container Akvarius for conducting the cultivation process, Glove box.

Operational Protocols
Grow blood cultures in microgravity environment to return to earth for study.

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Results/More Information

The research conducted allows to develop the methods for analyzing immunity system condition directly onboard the orbital space station.

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Results Publications

    Buravkova LB, Grigorieva OV, Rykova MP.  The effect of microgravity on the in vitro NK cell function during six International Space Station Missions. Microgravity Science and Technology. 2007; 19(5-6): 145-147. DOI: 10.1007/BF02919470.

    Rykova MP, Gertsik YG, Antropova EN, Buravkova LB.  Serum levels of immunoglobulins, allergen-specific IgE antibodies, and interleukin-4 in cosmonauts before and after short flights on the International Space Station. Human Physiology. 2006; 32(4): 457-460. DOI: 10.1134/S0362119706040128.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image The Intercellular Interaction experiment kit.
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image Glove Box.
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